chr12:89,411,690–89,412,513

chr12 : 89,411,690 – 89,412,513

823 bp 89 TFs 6 linked genes

This 823 bp open chromatin element is linked to 6 target genes and is bound by 89 transcription factors.

Linked Genes

6 genes

Gene	Expression	Dist. to TSS	Distance	Link type
ENSG00000286608		58.3 kb	Distal	Multiome+HiCAR
DUSP6		59.7 kb	Distal	Multiome+HiCAR
GALNT4		112.7 kb	Distal	Multiome
POC1B-AS1		113.5 kb	Distal	Multiome
POC1B		113.9 kb	Distal	Multiome
ATP2B1		297.3 kb	Distal	Multiome

Chromatin Accessibility

Genome Browser

Genomic view centred on this element. Tracks include ATAC-seq accessibility, RNA-seq expression, TF binding peaks, and element-to-gene loop arcs across the ESC → DE time course.

Transcription factors with ChIP-seq peak overlap or TOBIAS motif footprint evidence at this element.

TF Binding

89 transcription factors

ATF4 3 datasets

Motif DE_48h DE_48h-ATF4_MA0833.3 10 bp overlap

Motif DE_60h DE_60h-ATF4_MA0833.3 10 bp overlap

Motif DE_72h DE_72h-ATF4_MA0833.3 10 bp overlap

BCL6B 2 datasets

Motif DE_48h DE_48h-BCL6B_MA0731.1 17 bp overlap

Motif DE_60h DE_60h-BCL6B_MA0731.1 17 bp overlap

ChIP hiPSC_derived_lt-NES GSE108506.CHD7.hiPSC_derived_lt-NES 261 bp overlap

Cebpa 1 dataset

ChIP BLaER1 ENCFF262VBH 157 bp overlap

Motif DE_48h DE_48h-Crx_MA0467.3 6 bp overlap

Motif DE_60h DE_60h-Crx_MA0467.3 6 bp overlap

ChIP NTERA2 GSE58641.DDX5.NTERA2 115 bp overlap

EBF1 2 datasets

Motif DE_48h DE_48h-EBF1_MA0154.5 11 bp overlap

Motif DE_60h DE_60h-EBF1_MA0154.5 11 bp overlap

EOMES 1 dataset

ChIP hESC GSE26097.EOMES.hESC 160 bp overlap

ChIP TSU-1621MT_ATRA GSE60477.ERG.TSU-1621MT_ATRA 280 bp overlap

ChIP VCaP GSE49091.ERG.VCaP 140 bp overlap

ChIP GIST-T1 GSE106624.ETV1.GIST-T1 133 bp overlap

ETV2 2 datasets

Motif DE_48h DE_48h-ETV2_MA0762.2 9 bp overlap

Motif DE_60h DE_60h-ETV2_MA0762.2 9 bp overlap

Motif DE_60h DE_60h-ETV6_MA0645.2 9 bp overlap

Motif DE_60h DE_60h-ETV7_MA1708.2 9 bp overlap

Ebf4 2 datasets

Motif DE_48h DE_48h-Ebf4_MA2122.1 11 bp overlap

Motif DE_60h DE_60h-Ebf4_MA2122.1 11 bp overlap

FLI1 2 datasets

ChIP A-673_1_KRAB_GFP GSE106914.FLI1.A-673_1_KRAB_GFP 267 bp overlap

ChIP A-673_2_KRAB_eSOX2_1 GSE106914.FLI1.A-673_2_KRAB_eSOX2_1 214 bp overlap

FOXA2 2 datasets

ChIP DE DE-FOXA2-1 796 bp overlap

ChIP DE DE-FOXA2-2 823 bp overlap

GATA1 1 dataset

ChIP K-562_enCRISPRi-LK GSE132212.GATA1.K-562_enCRISPRi-LK 165 bp overlap

GATA1::TAL1 2 datasets

Motif DE_48h DE_48h-GATA1TAL1_MA0140.3 17 bp overlap

Motif DE_60h DE_60h-GATA1TAL1_MA0140.3 17 bp overlap

GATA2 1 dataset

ChIP TF1 GSE73207.GATA2.TF1 395 bp overlap

GATA4 4 datasets

ChIP DE DE-GATA4-1 690 bp overlap

ChIP DE DE-GATA4-2 823 bp overlap

ChIP foregut GSE117136.GATA4.foregut 496 bp overlap

ChIP pancreatic-progenitor GSE117136.GATA4.pancreatic-progenitor 434 bp overlap

GATA6 11 datasets

ChIP DE DE-GATA6-1 713 bp overlap

ChIP DE DE-GATA6-2 823 bp overlap

Motif DE_48h DE_48h-GATA6_MA1104.3 8 bp overlap

Motif DE_60h DE_60h-GATA6_MA1104.3 8 bp overlap

ChIP DE_D1 S14-DE-d1-GATA6-exp1 478 bp overlap

ChIP DE_D2 S55-DE-d2-GATA6-exp2 724 bp overlap

ChIP HUES-8_DE_JNKi GSE109524.GATA6.HUES-8_DE_JNKi 575 bp overlap

ChIP HUES-8_DE_ctrl GSE109524.GATA6.HUES-8_DE_ctrl 263 bp overlap

ChIP endoderm_KO GSE117136.GATA6.endoderm_KO 496 bp overlap

ChIP foregut GSE117136.GATA6.foregut 542 bp overlap

ChIP foregut_KO GSE117136.GATA6.foregut_KO 314 bp overlap

GFI1 3 datasets

Motif DE_48h DE_48h-GFI1_MA0038.3 11 bp overlap

Motif DE_60h DE_60h-GFI1_MA0038.3 11 bp overlap

Motif DE_72h DE_72h-GFI1_MA0038.3 11 bp overlap

GFI1B 1 dataset

ChIP K-562 ENCSR509GDT.GFI1B.K-562 111 bp overlap

Motif DE_48h DE_48h-GSC_MA0648.2 6 bp overlap

Motif DE_60h DE_60h-GSC_MA0648.2 6 bp overlap

GSC2 2 datasets

Motif DE_48h DE_48h-GSC2_MA0891.2 6 bp overlap

Motif DE_60h DE_60h-GSC2_MA0891.2 6 bp overlap

Gata3 2 datasets

Motif DE_48h DE_48h-Gata3_MA0037.5 8 bp overlap

Motif DE_60h DE_60h-Gata3_MA0037.5 8 bp overlap

Gfi1B 4 datasets

Motif DE_48h DE_48h-Gfi1B_MA0483.2 10 bp overlap

Motif DE_60h DE_60h-Gfi1B_MA0483.2 10 bp overlap

Motif DE_60h DE_60h-Gfi1B_MA0483.2 10 bp overlap

Motif DE_72h DE_72h-Gfi1B_MA0483.2 10 bp overlap

Hand1::Tcf3 1 dataset

Motif DE_60h DE_60h-Hand1Tcf3_MA0092.2 9 bp overlap

Hnf1A 2 datasets

Motif DE_48h DE_48h-Hnf1A_MA1991.2 10 bp overlap

Motif DE_60h DE_60h-Hnf1A_MA1991.2 10 bp overlap

ChIP TSU-1621MT GSE60477.LMO2.TSU-1621MT 230 bp overlap

Motif DE_60h DE_60h-MAZ_MA1522.2 8 bp overlap

MRTFB 1 dataset

ChIP A-673-clone-Asp114 GSE92738.MRTFB.A-673-clone-Asp114 266 bp overlap

ChIP Loucy GSE94000.MYB.Loucy 302 bp overlap

MYBL2 1 dataset

ChIP A-673 GSE119971.MYBL2.A-673 299 bp overlap

MZF1 2 datasets

Motif DE_48h DE_48h-MZF1_MA0056.3 8 bp overlap

Motif DE_60h DE_60h-MZF1_MA0056.3 8 bp overlap

NFATC3 3 datasets

Motif DE_48h DE_48h-NFATC3_MA0625.3 6 bp overlap

Motif DE_60h DE_60h-NFATC3_MA0625.3 6 bp overlap

Motif DE_72h DE_72h-NFATC3_MA0625.3 6 bp overlap

Nfatc1 3 datasets

Motif DE_48h DE_48h-Nfatc1_MA0624.3 6 bp overlap

Motif DE_60h DE_60h-Nfatc1_MA0624.3 6 bp overlap

Motif DE_72h DE_72h-Nfatc1_MA0624.3 6 bp overlap

OTX1 2 datasets

Motif DE_48h DE_48h-OTX1_MA0711.2 6 bp overlap

Motif DE_60h DE_60h-OTX1_MA0711.2 6 bp overlap

OTX2 2 datasets

Motif DE_48h DE_48h-OTX2_MA0712.3 7 bp overlap

Motif DE_60h DE_60h-OTX2_MA0712.3 7 bp overlap

PITX1 2 datasets

Motif DE_48h DE_48h-PITX1_MA0682.3 6 bp overlap

Motif DE_60h DE_60h-PITX1_MA0682.3 6 bp overlap

PITX2 2 datasets

Motif DE_48h DE_48h-PITX2_MA1547.2 8 bp overlap

Motif DE_60h DE_60h-PITX2_MA1547.2 8 bp overlap

PITX3 2 datasets

Motif DE_48h DE_48h-PITX3_MA0714.2 6 bp overlap

Motif DE_60h DE_60h-PITX3_MA0714.2 6 bp overlap

POU2F1 3 datasets

Motif DE_48h DE_48h-POU2F1_MA0785.2 9 bp overlap

Motif DE_60h DE_60h-POU2F1_MA0785.2 9 bp overlap

Motif DE_72h DE_72h-POU2F1_MA0785.2 9 bp overlap

POU2F1::SOX2 2 datasets

Motif DE_48h DE_48h-POU2F1SOX2_MA1962.1 17 bp overlap

Motif DE_60h DE_60h-POU2F1SOX2_MA1962.1 17 bp overlap

POU2F3 3 datasets

Motif DE_48h DE_48h-POU2F3_MA0627.3 9 bp overlap

Motif DE_60h DE_60h-POU2F3_MA0627.3 9 bp overlap

Motif DE_72h DE_72h-POU2F3_MA0627.3 9 bp overlap

POU3F1 3 datasets

Motif DE_48h DE_48h-POU3F1_MA0786.2 10 bp overlap

Motif DE_60h DE_60h-POU3F1_MA0786.2 10 bp overlap

Motif DE_72h DE_72h-POU3F1_MA0786.2 10 bp overlap

POU3F2 3 datasets

Motif DE_48h DE_48h-POU3F2_MA0787.1 12 bp overlap

Motif DE_60h DE_60h-POU3F2_MA0787.1 12 bp overlap

Motif DE_72h DE_72h-POU3F2_MA0787.1 12 bp overlap

POU3F3 3 datasets

Motif DE_48h DE_48h-POU3F3_MA0788.1 13 bp overlap

Motif DE_60h DE_60h-POU3F3_MA0788.1 13 bp overlap

Motif DE_72h DE_72h-POU3F3_MA0788.1 13 bp overlap

POU3F4 3 datasets

Motif DE_48h DE_48h-POU3F4_MA0789.1 9 bp overlap

Motif DE_60h DE_60h-POU3F4_MA0789.1 9 bp overlap

Motif DE_72h DE_72h-POU3F4_MA0789.1 9 bp overlap

POU5F1 3 datasets

Motif DE_48h DE_48h-POU5F1_MA1115.2 7 bp overlap

Motif DE_60h DE_60h-POU5F1_MA1115.2 7 bp overlap

Motif DE_72h DE_72h-POU5F1_MA1115.2 7 bp overlap

POU5F1B 3 datasets

Motif DE_48h DE_48h-POU5F1B_MA0792.1 9 bp overlap

Motif DE_60h DE_60h-POU5F1B_MA0792.1 9 bp overlap

Motif DE_72h DE_72h-POU5F1B_MA0792.1 9 bp overlap

Pou5f1::Sox2 2 datasets

Motif DE_48h DE_48h-Pou5f1Sox2_MA0142.1 15 bp overlap

Motif DE_60h DE_60h-Pou5f1Sox2_MA0142.1 15 bp overlap

RAD21 1 dataset

ChIP HUVEC-C_hypoxia GSE94872.RAD21.HUVEC-C_hypoxia 144 bp overlap

Motif DE_60h DE_60h-RARA_MA0729.1 18 bp overlap

RELA 3 datasets

ChIP HAEC_TNFa_4h GSE89970.RELA.HAEC_TNFa_4h 183 bp overlap

ChIP aortic-endothelial-cell_IL1B_D2 GSE139377.RELA.aortic-endothelial-cell_IL1B_D2 209 bp overlap

ChIP aortic-endothelial-cell_IL1B_D26 GSE139377.RELA.aortic-endothelial-cell_IL1B_D26 168 bp overlap

ChIP L1236 GSE63736.RELB.L1236 174 bp overlap

Motif DE_60h DE_60h-REST_MA0138.3 20 bp overlap

RHOXF1 2 datasets

Motif DE_48h DE_48h-RHOXF1_MA0719.2 6 bp overlap

Motif DE_60h DE_60h-RHOXF1_MA0719.2 6 bp overlap

SMAD2-3 2 datasets

ChIP HUES-8_DE GSE109524.SMAD2-3.HUES-8_DE 674 bp overlap

ChIP HUES-8_DE_JNKi GSE109524.SMAD2-3.HUES-8_DE_JNKi 303 bp overlap

SMARCA4 2 datasets

ChIP CTV-1_FLAG GSE128835.SMARCA4.CTV-1_FLAG 173 bp overlap

ChIP hiPSC GSE124903.SMARCA4.hiPSC 194 bp overlap

SMARCC1 1 dataset

ChIP DE_D1 S15-DE-d1-BAF155-exp1 322 bp overlap

SOX10 2 datasets

Motif DE_48h DE_48h-SOX10_MA0442.3 6 bp overlap

Motif DE_60h DE_60h-SOX10_MA0442.3 6 bp overlap

SOX17 1 dataset

ChIP DE_D2 DED2-SOX17_Batch_II 243 bp overlap

SOX17_M 1 dataset

ChIP DE_D2 DED2-SOX17-M_Batch_II 242 bp overlap

ChIP hiPSC GSE56567.SOX2.hiPSC 218 bp overlap

SOX4 2 datasets

Motif DE_48h DE_48h-SOX4_MA0867.3 8 bp overlap

Motif DE_60h DE_60h-SOX4_MA0867.3 8 bp overlap

SPI1 2 datasets

ChIP K-562 GSE70482.SPI1.K-562 224 bp overlap

ChIP K-562_NABUT GSE74999.SPI1.K-562_NABUT 114 bp overlap

Motif DE_60h DE_60h-SPIB_MA0081.3 13 bp overlap

Motif DE_48h DE_48h-SPIC_MA0687.2 13 bp overlap

Sox11 2 datasets

Motif DE_48h DE_48h-Sox11_MA0869.3 8 bp overlap

Motif DE_60h DE_60h-Sox11_MA0869.3 8 bp overlap

Sox17 2 datasets

Motif DE_48h DE_48h-Sox17_MA0078.3 10 bp overlap

Motif DE_60h DE_60h-Sox17_MA0078.3 10 bp overlap

Sox6 2 datasets

Motif DE_48h DE_48h-Sox6_MA0515.1 10 bp overlap

Motif DE_60h DE_60h-Sox6_MA0515.1 10 bp overlap

Sox7 2 datasets

Motif DE_48h DE_48h-Sox7_MA2095.1 10 bp overlap

Motif DE_60h DE_60h-Sox7_MA2095.1 10 bp overlap

Motif DE_48h DE_48h-Spi1_MA0080.7 13 bp overlap

Stat6 6 datasets

Motif DE_48h DE_48h-Stat6_MA0520.2 10 bp overlap

Motif DE_48h DE_48h-Stat6_MA0520.2 10 bp overlap

Motif DE_60h DE_60h-Stat6_MA0520.2 10 bp overlap

Motif DE_60h DE_60h-Stat6_MA0520.2 10 bp overlap

Motif DE_72h DE_72h-Stat6_MA0520.2 10 bp overlap

Motif DE_72h DE_72h-Stat6_MA0520.2 10 bp overlap

ChIP H9_ENDODERM GSE60606.T.H9_ENDODERM 179 bp overlap

TAL1 2 datasets

ChIP K-562 GSE107726.TAL1.K-562 367 bp overlap

ChIP TSU-1621MT GSE60477.TAL1.TSU-1621MT 250 bp overlap

TCF7L2 2 datasets

Motif DE_48h DE_48h-TCF7L2_MA0523.2 9 bp overlap

Motif DE_60h DE_60h-TCF7L2_MA0523.2 9 bp overlap

THAP1 1 dataset

Motif DE_60h DE_60h-THAP1_MA0597.3 8 bp overlap

TRPS1 2 datasets

Motif DE_48h DE_48h-TRPS1_MA1970.2 8 bp overlap

Motif DE_60h DE_60h-TRPS1_MA1970.2 8 bp overlap

ZNF189 1 dataset

Motif DE_60h DE_60h-ZNF189_MA1725.2 9 bp overlap

ZNF331 1 dataset

Motif DE_60h DE_60h-ZNF331_MA1726.2 10 bp overlap

ZNF35 3 datasets

Motif DE_48h DE_48h-ZNF35_MA2333.1 7 bp overlap

Motif DE_60h DE_60h-ZNF35_MA2333.1 7 bp overlap

Motif DE_72h DE_72h-ZNF35_MA2333.1 7 bp overlap

ZNF528 1 dataset

ChIP HEK293 GSE76494.ZNF528.HEK293 100 bp overlap

ZNF816 1 dataset

Motif DE_60h DE_60h-ZNF816_MA1719.2 15 bp overlap

Motif DE_48h DE_48h-Zfx_MA0146.3 10 bp overlap

Motif DE_60h DE_60h-Zfx_MA0146.3 10 bp overlap

Motif DE_72h DE_72h-Zfx_MA0146.3 10 bp overlap

Zic1::Zic2 1 dataset

Motif DE_60h DE_60h-Zic1Zic2_MA1628.2 7 bp overlap

Motif DE_60h DE_60h-Zic2_MA1629.2 9 bp overlap

Motif DE_60h DE_60h-Zic3_MA0697.3 7 bp overlap