Transcription factors with Perturb-seq knockdown data for POC1B-AS1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = POC1B-AS1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of POC1B-AS1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr12:89,344,903–89,347,295 | 179.8 kb | Distal (>10kb) Multiome | 690 | |
| chr12:89,351,407–89,355,035 | 171.7 kb | Distal (>10kb) Multiome HiCAR | 1222 | |
| chr12:89,411,690–89,412,513 | 113.5 kb | Distal (>10kb) Multiome | 89 | |
| chr12:89,524,103–89,526,498 | 437 bp | At TSS Multiome | 1007 | |
| chr12:89,529,864–89,530,021 | 5.3 kb | Proximal (<10kb) | 103 | |
| chr12:89,707,516–89,710,690 | 183.9 kb | Distal (>10kb) Multiome | 1065 | |
| chr12:89,777,305–89,778,322 | 252.2 kb | Distal (>10kb) Multiome | 135 |
Genomic view of the POC1B-AS1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.