Transcription factors with Perturb-seq knockdown data for ENSG00000286608. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ENSG00000286608 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ENSG00000286608, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr12:89,098,193–89,099,140 | 255.0 kb | Distal (>10kb) Multiome HiCAR | 188 | |
| chr12:89,225,440–89,226,374 | 127.8 kb | Distal (>10kb) Multiome HiCAR | 416 | |
| chr12:89,247,539–89,248,148 | 106.0 kb | Distal (>10kb) Multiome HiCAR | 291 | |
| chr12:89,344,903–89,347,295 | 7.9 kb | Proximal (<10kb) Multiome | 690 | |
| chr12:89,349,881–89,350,937 | 3.6 kb | Proximal (<10kb) Multiome | 360 | |
| chr12:89,351,407–89,355,035 | 100 bp | At TSS Multiome | 1222 | |
| chr12:89,355,213–89,355,578 | 1.5 kb | Proximal (<10kb) | 141 | |
| chr12:89,357,268–89,357,606 | 3.6 kb | Proximal (<10kb) | 262 | |
| chr12:89,411,690–89,412,513 | 58.3 kb | Distal (>10kb) Multiome HiCAR | 89 | |
| chr12:89,524,103–89,526,498 | 172.3 kb | Distal (>10kb) Multiome HiCAR | 1007 |
Genomic view of the ENSG00000286608 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.