chr8:42,831,245–42,833,658

chr8 : 42,831,245 – 42,833,658

2,413 bp 84 TFs 8 linked genes

This 2.4 kb open chromatin element is linked to 8 target genes and is bound by 84 transcription factors.

Linked Genes

8 genes

Gene	Expression	Dist. to TSS	Distance	Link type
ENSG00000286837		9.3 kb	Proximal	Proximity
THAP1		9.6 kb	Proximal	Proximity
HOOK3		65.2 kb	Distal	Multiome
RNF170		65.6 kb	Distal	Multiome
FNTA		224.6 kb	Distal	Multiome
POMK		261.8 kb	Distal	Multiome
SLC20A2		290.0 kb	Distal	Multiome
SMIM19		290.1 kb	Distal	Multiome

Chromatin Accessibility

Genome Browser

Genomic view centred on this element. Tracks include ATAC-seq accessibility, RNA-seq expression, TF binding peaks, and element-to-gene loop arcs across the ESC → DE time course.

Transcription factors with ChIP-seq peak overlap or TOBIAS motif footprint evidence at this element.

TF Binding

84 transcription factors

ChIP WA01 ENCSR000BQU.ATF2.WA01 165 bp overlap

Arid3a 1 dataset

Motif DE_48h DE_48h-Arid3a_MA0151.1 6 bp overlap

BCL6B 1 dataset

Motif DE_48h DE_48h-BCL6B_MA0731.1 17 bp overlap

BHLHE22 1 dataset

Motif DE_48h DE_48h-BHLHE22_MA1635.2 6 bp overlap

ChIP MV4-11_IBET151_50nM GSE120715.BRD3.MV4-11_IBET151_50nM 159 bp overlap

ChIP CD4_JG1 GSE33281.BRD4.CD4_JG1 397 bp overlap

ChIP artery_tibial ENCSR699BEK.CTCF.artery_tibial 126 bp overlap

Cebpa 4 datasets

ChIP BLaER1 ENCFF031ISE 346 bp overlap

ChIP BLaER1 ENCFF262VBH 418 bp overlap

ChIP BLaER1 ENCFF274GAT 357 bp overlap

ChIP BLaER1 ENCFF364PUR 251 bp overlap

Motif DE_48h DE_48h-EBF3_MA1637.2 9 bp overlap

EOMES 1 dataset

ChIP hESC GSE26097.EOMES.hESC 264 bp overlap

ChIP ProEs GSE59087.EZH1.ProEs 224 bp overlap

ChIP WSU-DLCL2 GSE45982.EZH2.WSU-DLCL2 134 bp overlap

Motif DE_48h DE_48h-Ebf2_MA1604.2 9 bp overlap

FOXA1 2 datasets

ChIP T-47D_shRNF2_45min GSE137579.FOXA1.T-47D_shRNF2_45min 164 bp overlap

ChIP breast-cancer_ENOB-2852 GSE128018.FOXA1.breast-cancer_ENOB-2852 192 bp overlap

FOXA2 4 datasets

ChIP DE DE-FOXA2-1 646 bp overlap

ChIP DE DE-FOXA2-1 584 bp overlap

ChIP DE DE-FOXA2-2 653 bp overlap

ChIP DE DE-FOXA2-2 608 bp overlap

FOXD3 1 dataset

Motif DE_48h DE_48h-FOXD3_MA0041.3 14 bp overlap

FOXH1 1 dataset

Motif DE_48h DE_48h-FOXH1_MA0479.2 8 bp overlap

FOXO1::ELK1 1 dataset

Motif DE_48h DE_48h-FOXO1ELK1_MA1954.2 13 bp overlap

FOXO1::ELK3 1 dataset

Motif DE_48h DE_48h-FOXO1ELK3_MA1955.2 13 bp overlap

FOXO1::FLI1 1 dataset

Motif DE_48h DE_48h-FOXO1FLI1_MA1956.2 13 bp overlap

GATA4 4 datasets

ChIP DE DE-GATA4-1 761 bp overlap

ChIP DE DE-GATA4-1 627 bp overlap

ChIP DE DE-GATA4-2 1035 bp overlap

ChIP DE DE-GATA4-2 690 bp overlap

GATA6 7 datasets

ChIP DE DE-GATA6-1 766 bp overlap

ChIP DE DE-GATA6-1 530 bp overlap

ChIP DE DE-GATA6-2 931 bp overlap

ChIP DE DE-GATA6-2 652 bp overlap

ChIP DE_D2 S55-DE-d2-GATA6-exp2 746 bp overlap

ChIP DE_D2 S55-DE-d2-GATA6-exp2 469 bp overlap

ChIP endoderm_KO GSE117136.GATA6.endoderm_KO 353 bp overlap

GLIS2 1 dataset

Motif DE_48h DE_48h-GLIS2_MA0736.1 14 bp overlap

GLIS3 1 dataset

Motif DE_48h DE_48h-GLIS3_MA0737.1 14 bp overlap

HDAC3 1 dataset

ChIP RH4_DMSO-6H GSE116344.HDAC3.RH4_DMSO-6H 311 bp overlap

Motif DE_48h DE_48h-HIC2_MA0738.2 6 bp overlap

INSM1 1 dataset

Motif DE_48h DE_48h-INSM1_MA0155.1 12 bp overlap

ChIP NCI-H929 GSE56857.IRF4.NCI-H929 85 bp overlap

ChIP DE_D2 S02-DE-d2-JUN-exp1 248 bp overlap

MED1 2 datasets

ChIP SGBS GSE64233.MED1.SGBS 302 bp overlap

ChIP SGBS_TNF GSE64233.MED1.SGBS_TNF 254 bp overlap

MEIS1 1 dataset

Motif DE_48h DE_48h-MEIS1_MA0498.3 5 bp overlap

Motif DE_48h DE_48h-MYB_MA0100.4 6 bp overlap

MYF6 2 datasets

Motif DE_36h DE_36h-MYF6_MA0667.1 10 bp overlap

Motif DE_48h DE_48h-MYF6_MA0667.1 10 bp overlap

NCOR1 1 dataset

ChIP LS180_125 GSE39277.NCOR1.LS180_125 101 bp overlap

NFATC3 1 dataset

Motif DE_48h DE_48h-NFATC3_MA0625.3 6 bp overlap

NKX2-1 1 dataset

ChIP H9_derived-cIN GSE99937.NKX2-1.H9_derived-cIN 54 bp overlap

NUTM1 2 datasets

ChIP embryonic-kidney_induced GSE133122.NUTM1.embryonic-kidney_induced 440 bp overlap

ChIP embryonic-kidney_induced GSE133122.NUTM1.embryonic-kidney_induced 468 bp overlap

Neurod2 1 dataset

Motif DE_48h DE_48h-Neurod2_MA1993.2 6 bp overlap

Nfatc1 1 dataset

Motif DE_48h DE_48h-Nfatc1_MA0624.3 6 bp overlap

Nfatc2 1 dataset

Motif DE_48h DE_48h-Nfatc2_MA0152.3 8 bp overlap

ONECUT1 1 dataset

Motif DE_48h DE_48h-ONECUT1_MA0679.3 9 bp overlap

ONECUT3 1 dataset

Motif DE_48h DE_48h-ONECUT3_MA0757.2 12 bp overlap

OSR1 2 datasets

Motif DE_36h DE_36h-OSR1_MA1542.2 8 bp overlap

Motif DE_48h DE_48h-OSR1_MA1542.2 8 bp overlap

Olig2 1 dataset

Motif DE_48h DE_48h-Olig2_MA1997.2 6 bp overlap

PAX3-FOXO1 2 datasets

ChIP RH3 GSE83726.PAX3-FOXO1.RH3 265 bp overlap

ChIP RH4 GSE140115.PAX3-FOXO1.RH4 302 bp overlap

PLAGL2 1 dataset

Motif DE_48h DE_48h-PLAGL2_MA1548.2 8 bp overlap

PPARG 1 dataset

ChIP ASC GSE21366.PPARG.ASC 195 bp overlap

Ptf1A 1 dataset

Motif DE_48h DE_48h-Ptf1A_MA1619.2 8 bp overlap

SMAD2 1 dataset

ChIP endoderm GSE29422.SMAD2.endoderm 166 bp overlap

SMAD2-3 3 datasets

ChIP HUES-8_DE GSE109524.SMAD2-3.HUES-8_DE 960 bp overlap

ChIP HUVEC-C_TGFB1 GSE134556.SMAD2-3.HUVEC-C_TGFB1 347 bp overlap

ChIP HUVEC-C_TGFB1 GSE134556.SMAD2-3.HUVEC-C_TGFB1 369 bp overlap

SMAD2_3 4 datasets

ChIP DE_D2 S01-DE-d2-SMAD2_3-exp1 1000 bp overlap

ChIP DE_D2 S01-DE-d2-SMAD2_3-exp1 649 bp overlap

ChIP DE_D2 S53-DE-d2-SMAD2_3-exp2 1072 bp overlap

ChIP DE_D2 S53-DE-d2-SMAD2_3-exp2 623 bp overlap

SMAD3 1 dataset

ChIP endoderm GSE29422.SMAD3.endoderm 189 bp overlap

SMAD4 1 dataset

ChIP endoderm GSE29422.SMAD4.endoderm 244 bp overlap

SOX15 1 dataset

Motif DE_48h DE_48h-SOX15_MA1152.2 7 bp overlap

SOX17 2 datasets

ChIP DE_D2 DED2-SOX17_Batch_II 251 bp overlap

ChIP DE_D2 DED2-SOX17_Batch_II 256 bp overlap

SOX17_M 2 datasets

ChIP DE_D2 DED2-SOX17-M_Batch_II 979 bp overlap

ChIP DE_D2 DED2-SOX17-M_Batch_II 683 bp overlap

SOX18 1 dataset

Motif DE_48h DE_48h-SOX18_MA1563.2 8 bp overlap

Motif DE_48h DE_48h-SOX8_MA0868.3 7 bp overlap

Motif DE_48h DE_48h-SOX9_MA0077.2 8 bp overlap

Motif DE_48h DE_48h-SRY_MA0084.2 7 bp overlap

SUPT5H 1 dataset

ChIP HeLa GSE125534.SUPT5H.HeLa 152 bp overlap

Sox17 1 dataset

Motif DE_48h DE_48h-Sox17_MA0078.3 10 bp overlap

Motif DE_48h DE_48h-Sox5_MA0087.3 8 bp overlap

Motif DE_48h DE_48h-Sox6_MA0515.1 10 bp overlap

Motif DE_48h DE_48h-Sox7_MA2095.1 10 bp overlap

ChIP H9_ENDODERM GSE60606.T.H9_ENDODERM 188 bp overlap

TBX19 1 dataset

Motif DE_48h DE_48h-TBX19_MA0804.2 17 bp overlap

Motif DE_48h DE_48h-TBXT_MA0009.2 16 bp overlap

TFAP2A 1 dataset

Motif DE_48h DE_48h-TFAP2A_MA0810.2 11 bp overlap

TFAP2B 1 dataset

Motif DE_48h DE_48h-TFAP2B_MA0811.2 11 bp overlap

TFAP2C 3 datasets

Motif DE_48h DE_48h-TFAP2C_MA0524.3 11 bp overlap

ChIP HCC1954 GSE126897.TFAP2C.HCC1954 163 bp overlap

ChIP HCC1954 GSE126897.TFAP2C.HCC1954 283 bp overlap

TFAP4 1 dataset

Motif DE_48h DE_48h-TFAP4_MA0691.1 10 bp overlap

TP63 2 datasets

ChIP foreskin GSE126390.TP63.foreskin 154 bp overlap

ChIP foreskin GSE126390.TP63.foreskin 94 bp overlap

Tcf12 1 dataset

Motif DE_48h DE_48h-Tcf12_MA0521.3 6 bp overlap

Thap11 1 dataset

Motif DE_48h DE_48h-Thap11_MA1573.2 14 bp overlap

Twist2 1 dataset

Motif DE_48h DE_48h-Twist2_MA0633.3 6 bp overlap

ZNF316 1 dataset

ChIP K-562 ENCSR200JYP.ZNF316.K-562 370 bp overlap

ZNF317 1 dataset

Motif DE_48h DE_48h-ZNF317_MA1593.2 8 bp overlap

ZNF350 1 dataset

ChIP HEK293 GSE76494.ZNF350.HEK293 141 bp overlap

ZNF354A 1 dataset

Motif DE_48h DE_48h-ZNF354A_MA1978.2 20 bp overlap

ZNF449 1 dataset

ChIP HEK293 ENCFF764ZIC 411 bp overlap

ZNF680 3 datasets

ChIP HEK293 ENCFF418WHE 226 bp overlap

ChIP HEK293 ENCSR307CKC.ZNF680.HEK293 290 bp overlap

ChIP HEK293 GSE76494.ZNF680.HEK293 244 bp overlap

Zic1::Zic2 2 datasets

Motif DE_36h DE_36h-Zic1Zic2_MA1628.2 7 bp overlap

Motif DE_48h DE_48h-Zic1Zic2_MA1628.2 7 bp overlap

Zic3 2 datasets

Motif DE_36h DE_36h-Zic3_MA0697.3 7 bp overlap

Motif DE_48h DE_48h-Zic3_MA0697.3 7 bp overlap