Predicted to be located in membrane. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for SMIM19. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = SMIM19 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of SMIM19, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr8:42,270,718–42,271,870 | 270.3 kb | Distal (>10kb) Multiome | 668 | |
| chr8:42,337,948–42,339,165 | 203.1 kb | Distal (>10kb) Multiome | 710 | |
| chr8:42,376,919–42,377,769 | 164.2 kb | Distal (>10kb) Multiome | 159 | |
| chr8:42,391,151–42,392,597 | 149.8 kb | Distal (>10kb) Multiome | 831 | |
| chr8:42,541,069–42,542,355 | 118 bp | At TSS Multiome | 767 | |
| chr8:42,571,247–42,571,811 | 30.0 kb | Distal (>10kb) Multiome | 205 | |
| chr8:42,692,358–42,693,015 | 151.1 kb | Distal (>10kb) Multiome | 396 | |
| chr8:42,831,245–42,833,658 | 290.1 kb | Distal (>10kb) Multiome | 84 |
Genomic view of the SMIM19 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.