Prenyltransferases can attach either a farnesyl group or a geranylgeranyl group in thioether linkage to the cysteine residue of proteins with a C-terminal CAAX box. CAAX geranylgeranyltransferase and CAAX farnesyltransferase are heterodimers that share the same alpha subunit but have different beta subunits. This gene encodes the alpha subunit of these transferases. Alternative splicing results in multiple transcript variants. Related pseudogenes have been identified on chromosomes 11 and 13. [provided by RefSeq, May 2010]
Transcription factors with Perturb-seq knockdown data for FNTA. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = FNTA upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of FNTA, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr8:42,831,245–42,833,658 | 224.6 kb | Distal (>10kb) Multiome | 84 | |
| chr8:42,842,552–42,843,812 | 213.1 kb | Distal (>10kb) Multiome | 969 | |
| chr8:42,895,783–42,897,989 | 159.6 kb | Distal (>10kb) Multiome | 792 | |
| chr8:43,055,656–43,057,748 | 13 bp | At TSS Multiome | 1003 | |
| chr8:43,092,366–43,094,313 | 37.3 kb | Distal (>10kb) Multiome | 903 | |
| chr8:43,138,945–43,139,610 | 82.9 kb | Distal (>10kb) Multiome | 219 | |
| chr8:43,139,728–43,142,039 | 85.3 kb | Distal (>10kb) Multiome | 861 |
Genomic view of the FNTA locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.