chr5:177,083,311–177,083,887

chr5 : 177,083,311 – 177,083,887

576 bp 69 TFs 8 linked genes

This 576 bp open chromatin element is linked to 8 target genes and is bound by 69 transcription factors.

Linked Genes

8 genes

Gene	Expression	Dist. to TSS	Distance	Link type
FGFR4		3.0 kb	Proximal	Proximity
NSD1		48.3 kb	Distal	Multiome
ZNF346		60.9 kb	Distal	Multiome
UIMC1		76.8 kb	Distal	Multiome
PRELID1		220.2 kb	Distal	Multiome
MXD3		228.3 kb	Distal	Multiome
LMAN2		268.3 kb	Distal	Multiome
RGS14		283.7 kb	Distal	Multiome

Chromatin Accessibility

Genome Browser

Genomic view centred on this element. Tracks include ATAC-seq accessibility, RNA-seq expression, TF binding peaks, and element-to-gene loop arcs across the ESC → DE time course.

Transcription factors with ChIP-seq peak overlap or TOBIAS motif footprint evidence at this element.

TF Binding

69 transcription factors

ChIP K562 ENCFF492SKF 503 bp overlap

ARID1B 1 dataset

ChIP K-562 ENCSR822CCM.ARID1B.K-562 286 bp overlap

ARNT 2 datasets

ChIP GM12878 ENCFF831TWO 262 bp overlap

ChIP GM12878 ENCSR590KEQ.ARNT.GM12878 398 bp overlap

Ahr::Arnt 1 dataset

Motif DE_48h DE_48h-AhrArnt_MA0006.2 5 bp overlap

ChIP K-562 ENCSR808AKZ.BCOR.K-562 193 bp overlap

CBFA2T2 2 datasets

ChIP K-562 ENCSR699PVC.CBFA2T2.K-562 280 bp overlap

ChIP K562 ENCFF963TXY 381 bp overlap

CBFA2T3 2 datasets

ChIP K-562 ENCSR697YLJ.CBFA2T3.K-562 362 bp overlap

ChIP K562 ENCFF673OEZ 184 bp overlap

ChIP Caco-2_PROLIF GSE23436.CDX2.Caco-2_PROLIF 155 bp overlap

CEBPD 1 dataset

ChIP K-562 ENCSR000BVY.CEBPD.K-562 149 bp overlap

ChIP K-562 ENCSR077DKV.CREM.K-562 123 bp overlap

ChIP fibroblast of lung ENCFF356FDN 308 bp overlap

Cebpa 2 datasets

ChIP BLaER1 ENCFF031ISE 280 bp overlap

ChIP BLaER1 ENCFF093OYK 251 bp overlap

DMRTA2 2 datasets

Motif DE_48h DE_48h-DMRTA2_MA1478.2 6 bp overlap

Motif DE_72h DE_72h-DMRTA2_MA1478.2 6 bp overlap

ChIP K562 ENCFF775HUO 569 bp overlap

Dmrt1 1 dataset

Motif DE_72h DE_72h-Dmrt1_MA1603.2 9 bp overlap

EOMES 1 dataset

ChIP hESC GSE26097.EOMES.hESC 197 bp overlap

ChIP cardiomyocyte_D9 GSE129986.ETS1.cardiomyocyte_D9 272 bp overlap

ChIP SF8628 GSE94834.EZH2.SF8628 576 bp overlap

FEZF2 2 datasets

Motif DE_48h DE_48h-FEZF2_MA2341.1 8 bp overlap

Motif DE_72h DE_72h-FEZF2_MA2341.1 8 bp overlap

FOXA1 1 dataset

ChIP pancreatic-progenitor_PP1 GSE104840.FOXA1.pancreatic-progenitor_PP1 238 bp overlap

FOXA2 3 datasets

ChIP Caco-2 GSE66218.FOXA2.Caco-2 131 bp overlap

ChIP DE DE-FOXA2-1 371 bp overlap

ChIP DE DE-FOXA2-2 325 bp overlap

GATA1 6 datasets

ChIP HUDEP-2_30min GSE104676.GATA1.HUDEP-2_30min 77 bp overlap

ChIP K-562 GSE107726.GATA1.K-562 319 bp overlap

ChIP K-562 ENCSR000EFT.GATA1.K-562 156 bp overlap

ChIP K-562_dCas9-LSD1 GSE132212.GATA1.K-562_dCas9-LSD1 212 bp overlap

ChIP K-562_enCRISPRi-LK GSE132212.GATA1.K-562_enCRISPRi-LK 260 bp overlap

ChIP K562 ENCFF094CMK 251 bp overlap

GATA2 5 datasets

Motif DE_48h DE_48h-GATA2_MA0036.4 7 bp overlap

Motif DE_48h DE_48h-GATA2_MA0036.4 7 bp overlap

Motif DE_72h DE_72h-GATA2_MA0036.4 7 bp overlap

Motif DE_72h DE_72h-GATA2_MA0036.4 7 bp overlap

ChIP dermal-fibroblast_alone GSE51025.GATA2.dermal-fibroblast_alone 175 bp overlap

GATA4 10 datasets

ChIP BJ1-hTERT_FOXA2_GATA4_Coexp GSE92491.GATA4.BJ1-hTERT_FOXA2_GATA4_Coexp 233 bp overlap

ChIP DE DE-GATA4-1 576 bp overlap

ChIP DE DE-GATA4-2 576 bp overlap

Motif DE_48h DE_48h-GATA4_MA0482.3 8 bp overlap

Motif DE_48h DE_48h-GATA4_MA0482.3 8 bp overlap

Motif DE_72h DE_72h-GATA4_MA0482.3 8 bp overlap

Motif DE_72h DE_72h-GATA4_MA0482.3 8 bp overlap

ChIP foregut GSE117136.GATA4.foregut 468 bp overlap

ChIP pancreatic-progenitor GSE117136.GATA4.pancreatic-progenitor 525 bp overlap

ChIP pancreatic-progenitor_PP1 GSE104840.GATA4.pancreatic-progenitor_PP1 397 bp overlap

GATA6 20 datasets

ChIP Caco-2_PROLIF GSE23436.GATA6.Caco-2_PROLIF 211 bp overlap

ChIP DE DE-GATA6-1 561 bp overlap

ChIP DE DE-GATA6-2 576 bp overlap

Motif DE_48h DE_48h-GATA6_MA1104.3 8 bp overlap

Motif DE_48h DE_48h-GATA6_MA1104.3 8 bp overlap

Motif DE_72h DE_72h-GATA6_MA1104.3 8 bp overlap

Motif DE_72h DE_72h-GATA6_MA1104.3 8 bp overlap

ChIP DE_D1 S09-DE-d1-GATA6-exp1 374 bp overlap

ChIP DE_D1 S14-DE-d1-GATA6-exp1 435 bp overlap

ChIP DE_D1 S41-DE-d1-GATA6-exp2 460 bp overlap

ChIP DE_D2 S55-DE-d2-GATA6-exp2 520 bp overlap

ChIP HUES-8_DE_JNKi GSE109524.GATA6.HUES-8_DE_JNKi 430 bp overlap

ChIP HUES-8_DE_ctrl GSE109524.GATA6.HUES-8_DE_ctrl 412 bp overlap

ChIP YCC-3 GSE51705.GATA6.YCC-3 124 bp overlap

ChIP endoderm_KO GSE117136.GATA6.endoderm_KO 522 bp overlap

ChIP foregut GSE117136.GATA6.foregut 492 bp overlap

ChIP foregut_KO GSE117136.GATA6.foregut_KO 385 bp overlap

ChIP pancreatic-progenitor GSE117136.GATA6.pancreatic-progenitor 492 bp overlap

ChIP pancreatic-progenitor_KO GSE117136.GATA6.pancreatic-progenitor_KO 441 bp overlap

ChIP pancreatic-progenitor_PP1 GSE104840.GATA6.pancreatic-progenitor_PP1 408 bp overlap

Gata3 4 datasets

Motif DE_48h DE_48h-Gata3_MA0037.5 8 bp overlap

Motif DE_48h DE_48h-Gata3_MA0037.5 8 bp overlap

Motif DE_72h DE_72h-Gata3_MA0037.5 8 bp overlap

Motif DE_72h DE_72h-Gata3_MA0037.5 8 bp overlap

HDAC1 1 dataset

ChIP K-562 ENCSR387UWP.HDAC1.K-562 222 bp overlap

HDAC2 2 datasets

ChIP K-562 ENCSR893WSB.HDAC2.K-562 225 bp overlap

ChIP K562 ENCFF744ALD 421 bp overlap

HNF1A 2 datasets

Motif DE_48h DE_48h-HNF1A_MA0046.3 13 bp overlap

Motif DE_72h DE_72h-HNF1A_MA0046.3 13 bp overlap

HNF1B 2 datasets

Motif DE_48h DE_48h-HNF1B_MA0153.2 13 bp overlap

Motif DE_72h DE_72h-HNF1B_MA0153.2 13 bp overlap

IKZF1 1 dataset

ChIP GM12878 ENCFF753XDO 405 bp overlap

KDM1A 3 datasets

ChIP K562 ENCFF128TYE 54 bp overlap

ChIP pancreatic-progenitor_GT GSE104840.KDM1A.pancreatic-progenitor_GT 136 bp overlap

ChIP pancreatic-progenitor_PP2-KDM1A-inh GSE104840.KDM1A.pancreatic-progenitor_PP2-KDM1A-inh 237 bp overlap

ChIP K-562 GSE142227.LDB1.K-562 198 bp overlap

MAFK 2 datasets

Motif DE_48h DE_48h-MAFK_MA0496.4 10 bp overlap

Motif DE_72h DE_72h-MAFK_MA0496.4 10 bp overlap

MEIS1 1 dataset

Motif DE_48h DE_48h-MEIS1_MA0498.3 5 bp overlap

MEIS2 2 datasets

ChIP K-562 ENCSR851BNE.MEIS2.K-562 290 bp overlap

ChIP K562 ENCFF320GSD 381 bp overlap

Mafg 2 datasets

Motif DE_48h DE_48h-Mafg_MA0659.4 12 bp overlap

Motif DE_72h DE_72h-Mafg_MA0659.4 12 bp overlap

ChIP GM12878 ENCSR278SQL.NBN.GM12878 216 bp overlap

NFATC3 1 dataset

ChIP GM12878 ENCSR437GBJ.NFATC3.GM12878 150 bp overlap

NFKB1 1 dataset

ChIP L1236 GSE63736.NFKB1.L1236 190 bp overlap

NFKB2 1 dataset

ChIP L1236 GSE63736.NFKB2.L1236 166 bp overlap

NKX2-5 2 datasets

ChIP hESC_ab3584 GSE89457.NKX2-5.hESC_ab3584 284 bp overlap

ChIP hESC_sc-14033 GSE89457.NKX2-5.hESC_sc-14033 186 bp overlap

PAX3 2 datasets

Motif DE_48h DE_48h-PAX3_MA0780.1 10 bp overlap

Motif DE_72h DE_72h-PAX3_MA0780.1 10 bp overlap

PDX1 3 datasets

ChIP hESC GSE58685.PDX1.hESC 135 bp overlap

ChIP hiPSC GSE125768.PDX1.hiPSC 214 bp overlap

ChIP hiPSC_derived_PPs GSE106949.PDX1.hiPSC_derived_PPs 166 bp overlap

PKNOX1 3 datasets

ChIP GM12878 ENCFF589FCY 437 bp overlap

ChIP GM12878 ENCSR711XNY.PKNOX1.GM12878 272 bp overlap

ChIP K-562 ENCSR115SMW.PKNOX1.K-562 229 bp overlap

Pax7 2 datasets

Motif DE_48h DE_48h-Pax7_MA0680.3 10 bp overlap

Motif DE_72h DE_72h-Pax7_MA0680.3 10 bp overlap

ChIP LNCaP_SIFOXA1_TNFA GSE83860.RELA.LNCaP_SIFOXA1_TNFA 122 bp overlap

ChIP GM12878 ENCSR212YKD.SKIL.GM12878 395 bp overlap

SMAD2 1 dataset

ChIP endoderm GSE29422.SMAD2.endoderm 223 bp overlap

SMAD2-3 1 dataset

ChIP HUES-8_DE GSE109524.SMAD2-3.HUES-8_DE 490 bp overlap

SMAD2_3 2 datasets

ChIP DE_D2 S01-DE-d2-SMAD2_3-exp1 506 bp overlap

ChIP DE_D2 S53-DE-d2-SMAD2_3-exp2 423 bp overlap

SMAD4 2 datasets

ChIP Caco-2 GSE112946.SMAD4.Caco-2 204 bp overlap

ChIP endoderm GSE29422.SMAD4.endoderm 151 bp overlap

SMARCA4 2 datasets

ChIP K-562 ENCSR643VTW.SMARCA4.K-562 270 bp overlap

ChIP K-562 ENCSR587OQL.SMARCA4.K-562 307 bp overlap

SMARCA5 1 dataset

ChIP GM12878 ENCSR706YUH.SMARCA5.GM12878 183 bp overlap

SOX17_M 1 dataset

ChIP DE_D2 DED2-SOX17-M_Batch_II 340 bp overlap

ChIP K-562 ENCSR788RSW.SOX6.K-562 204 bp overlap

TAL1 5 datasets

ChIP K-562 GSE107726.TAL1.K-562 177 bp overlap

ChIP K-562_dCas9-KRAB GSE132212.TAL1.K-562_dCas9-KRAB 194 bp overlap

ChIP K-562_dCas9-LSD1 GSE132212.TAL1.K-562_dCas9-LSD1 235 bp overlap

ChIP K-562_enCRISPRi-KL GSE132212.TAL1.K-562_enCRISPRi-KL 246 bp overlap

ChIP K-562_enCRISPRi-LK GSE132212.TAL1.K-562_enCRISPRi-LK 194 bp overlap

ChIP K-562 ENCSR000EHA.TBP.K-562 153 bp overlap

TBX21 3 datasets

ChIP GM12878 ENCFF951HUW 159 bp overlap

ChIP GM12878 ENCFF951HUW 416 bp overlap

ChIP GM12878 ENCSR739IHN.TBX21.GM12878 245 bp overlap

TRPS1 4 datasets

Motif DE_48h DE_48h-TRPS1_MA1970.2 8 bp overlap

Motif DE_48h DE_48h-TRPS1_MA1970.2 8 bp overlap

Motif DE_72h DE_72h-TRPS1_MA1970.2 8 bp overlap

Motif DE_72h DE_72h-TRPS1_MA1970.2 8 bp overlap

ZBTB7A 2 datasets

ChIP K-562 GSE103445.ZBTB7A.K-562 236 bp overlap

ChIP K-562 ENCSR000BME.ZBTB7A.K-562 91 bp overlap

ChIP K-562 ENCSR004GKA.ZEB2.K-562 258 bp overlap

ZNF121 1 dataset

ChIP HepG2 ENCFF343YSL 164 bp overlap

ZNF213 2 datasets

Motif DE_48h DE_48h-ZNF213_MA2121.1 12 bp overlap

Motif DE_72h DE_72h-ZNF213_MA2121.1 12 bp overlap

ZNF24 3 datasets

ChIP K-562 ENCSR099NCH.ZNF24.K-562 59 bp overlap

ChIP K562 ENCFF615YYW 108 bp overlap

ChIP K562 ENCFF877JCX 63 bp overlap

ZNF331 2 datasets

Motif DE_48h DE_48h-ZNF331_MA1726.2 10 bp overlap

Motif DE_72h DE_72h-ZNF331_MA1726.2 10 bp overlap

ZNF75A 2 datasets

Motif DE_48h DE_48h-ZNF75A_MA2097.1 12 bp overlap

Motif DE_72h DE_72h-ZNF75A_MA2097.1 12 bp overlap

ZNF75D 2 datasets

Motif DE_48h DE_48h-ZNF75D_MA1601.2 12 bp overlap

Motif DE_72h DE_72h-ZNF75D_MA1601.2 12 bp overlap

ZNF816 2 datasets

Motif DE_48h DE_48h-ZNF816_MA1719.2 15 bp overlap

Motif DE_72h DE_72h-ZNF816_MA1719.2 15 bp overlap