The protein encoded by this gene is a tyrosine kinase and cell surface receptor for fibroblast growth factors. The encoded protein is involved in the regulation of several pathways, including cell proliferation, cell differentiation, cell migration, lipid metabolism, bile acid biosynthesis, vitamin D metabolism, glucose uptake, and phosphate homeostasis. This protein consists of an extracellular region, composed of three immunoglobulin-like domains, a single hydrophobic membrane-spanning segment, and a cytoplasmic tyrosine kinase domain. The extracellular portion interacts with fibroblast growth factors, setting in motion a cascade of downstream signals, ultimately influencing mitogenesis and differentiation. [provided by RefSeq, Aug 2017]
Transcription factors with Perturb-seq knockdown data for FGFR4. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = FGFR4 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of FGFR4, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr5:176,809,543–176,810,815 | 276.6 kb | Distal (>10kb) Multiome | 404 | |
| chr5:176,817,316–176,818,386 | 268.9 kb | Distal (>10kb) Multiome | 358 | |
| chr5:176,866,834–176,867,401 | 219.8 kb | Distal (>10kb) Multiome | 90 | |
| chr5:176,938,324–176,938,817 | 148.2 kb | Distal (>10kb) Multiome | 37 | |
| chr5:177,005,819–177,007,175 | 80.2 kb | Distal (>10kb) Multiome | 972 | |
| chr5:177,022,405–177,023,229 | 64.2 kb | Distal (>10kb) Multiome | 767 | |
| chr5:177,083,311–177,083,887 | 3.3 kb | Proximal (<10kb) Multiome | 69 | |
| chr5:177,086,049–177,087,797 | 66 bp | At TSS Multiome | 867 | |
| chr5:177,116,759–177,117,326 | 30.1 kb | Distal (>10kb) Multiome | 369 | |
| chr5:177,131,498–177,134,721 | 46.8 kb | Distal (>10kb) Multiome | 724 | |
| chr5:177,303,008–177,304,238 | 216.8 kb | Distal (>10kb) Multiome | 850 | |
| chr5:177,309,549–177,310,172 | 222.9 kb | Distal (>10kb) Multiome | 373 | |
| chr5:177,311,267–177,313,178 | 225.4 kb | Distal (>10kb) Multiome | 798 | |
| chr5:177,351,374–177,352,243 | 265.0 kb | Distal (>10kb) Multiome | 832 | |
| chr5:177,362,756–177,363,624 | 276.3 kb | Distal (>10kb) Multiome | 479 | |
| chr5:177,366,082–177,368,548 | 280.3 kb | Distal (>10kb) Multiome | 626 | |
| chr5:177,370,255–177,371,449 | 284.0 kb | Distal (>10kb) Multiome | 584 |
Genomic view of the FGFR4 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.