This gene encodes a nuclear protein that interacts with Brca1 (breast cancer 1) in a complex to recognize and repair DNA lesions. This protein binds ubiquitinated lysine 63 of histone H2A and H2AX. This protein may also function as a repressor of transcription. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2015]
Transcription factors with Perturb-seq knockdown data for UIMC1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = UIMC1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of UIMC1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr5:176,660,849–176,661,318 | 345.8 kb | Distal (>10kb) Multiome HiCAR | 382 | |
| chr5:176,809,543–176,810,815 | 196.4 kb | Distal (>10kb) Multiome HiCAR | 404 | |
| chr5:176,817,316–176,818,386 | 188.8 kb | Distal (>10kb) Multiome HiCAR | 358 | |
| chr5:176,866,834–176,867,401 | 139.7 kb | Distal (>10kb) Multiome | 90 | |
| chr5:176,938,324–176,938,817 | 68.1 kb | Distal (>10kb) Multiome | 37 | |
| chr5:177,005,819–177,007,175 | 67 bp | At TSS Multiome | 972 | |
| chr5:177,022,405–177,023,229 | 15.9 kb | Distal (>10kb) Multiome | 767 | |
| chr5:177,083,311–177,083,887 | 76.8 kb | Distal (>10kb) Multiome | 69 | |
| chr5:177,086,049–177,087,797 | 80.1 kb | Distal (>10kb) Multiome | 867 | |
| chr5:177,116,759–177,117,326 | 110.2 kb | Distal (>10kb) Multiome | 369 | |
| chr5:177,131,498–177,134,721 | 126.9 kb | Distal (>10kb) Multiome | 724 | |
| chr5:177,303,008–177,304,238 | 296.9 kb | Distal (>10kb) Multiome | 850 |
Genomic view of the UIMC1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.