RGS14
regulator of G protein signaling 14

This gene encodes a member of the regulator of G-protein signaling family. This protein contains one RGS domain, two Raf-like Ras-binding domains (RBDs), and one GoLoco domain. The protein attenuates the signaling activity of G-proteins by binding, through its GoLoco domain, to specific types of activated, GTP-bound G alpha subunits. Acting as a GTPase activating protein (GAP), the protein increases the rate of conversion of the GTP to GDP. This hydrolysis allows the G alpha subunits to bind G beta/gamma subunit heterodimers, forming inactive G-protein heterotrimers, thereby terminating the signal. Alternate transcriptional splice variants of this gene have been observed but have not been thoroughly characterized. [provided by RefSeq, Jul 2008]

Biological processes 87 terms
G protein-coupled receptor signaling pathway (GO:0007186)G-protein alpha-subunit binding (GO:0001965)GDP-dissociation inhibitor activity (GO:0005092)GDP-dissociation inhibitor activity (GO:0005092)GTPase activating protein binding (GO:0032794)GTPase activator activity (GO:0005096)GTPase activator activity (GO:0005096)GTPase activator activity (GO:0005096)GTPase activator activity (GO:0005096)GTPase activity (GO:0003924)GTPase activity (GO:0003924)GTPase regulator activity (GO:0030695)PML body (GO:0016605)cell division (GO:0051301)cell division (GO:0051301)centrosome (GO:0005813)centrosome (GO:0005813)centrosome (GO:0005813)chromosome segregation (GO:0007059)chromosome segregation (GO:0007059)cytoplasm (GO:0005737)cytoplasm (GO:0005737)cytoplasm (GO:0005737)dendrite (GO:0030425)dendrite (GO:0030425)dendritic spine (GO:0043197)dendritic spine (GO:0043197)glutamatergic synapse (GO:0098978)learning (GO:0007612)learning (GO:0007612)long-term memory (GO:0007616)long-term memory (GO:0007616)long-term memory (GO:0007616)long-term synaptic potentiation (GO:0060291)long-term synaptic potentiation (GO:0060291)long-term synaptic potentiation (GO:0060291)membrane (GO:0016020)microtubule binding (GO:0008017)microtubule binding (GO:0008017)modulation of chemical synaptic transmission (GO:0050804)negative regulation of ERK1 and ERK2 cascade (GO:0070373)negative regulation of ERK1 and ERK2 cascade (GO:0070373)negative regulation of G protein-coupled receptor signaling pathway (GO:0045744)negative regulation of G protein-coupled receptor signaling pathway (GO:0045744)negative regulation of MAP kinase activity (GO:0043407)negative regulation of synaptic plasticity (GO:0031914)negative regulation of synaptic plasticity (GO:0031914)nuclear body (GO:0016604)nuclear body (GO:0016604)nucleocytoplasmic transport (GO:0006913)nucleocytoplasmic transport (GO:0006913)nucleus (GO:0005634)nucleus (GO:0005634)nucleus (GO:0005634)plasma membrane (GO:0005886)plasma membrane (GO:0005886)plasma membrane (GO:0005886)plasma membrane (GO:0005886)plasma membrane (GO:0005886)platelet-derived growth factor receptor signaling pathway (GO:0048008)platelet-derived growth factor receptor signaling pathway (GO:0048008)positive regulation of neurogenesis (GO:0050769)positive regulation of neurogenesis (GO:0050769)postsynaptic density (GO:0014069)postsynaptic density (GO:0014069)protein binding (GO:0005515)protein kinase binding (GO:0019901)regulation of G protein-coupled receptor signaling pathway (GO:0008277)regulation of G protein-coupled receptor signaling pathway (GO:0008277)regulation of G protein-coupled receptor signaling pathway (GO:0008277)regulation of G protein-coupled receptor signaling pathway (GO:0008277)response to oxidative stress (GO:0006979)response to oxidative stress (GO:0006979)signal transduction (GO:0007165)signaling receptor complex adaptor activity (GO:0030159)signaling receptor complex adaptor activity (GO:0030159)spindle (GO:0005819)spindle (GO:0005819)spindle organization (GO:0007051)spindle organization (GO:0007051)spindle organization (GO:0007051)spindle pole (GO:0000922)spindle pole (GO:0000922)visual learning (GO:0008542)visual learning (GO:0008542)zygote asymmetric cell division (GO:0010070)zygote asymmetric cell division (GO:0010070)
Expression (TPM)
RGS14 — as a Regulated Gene

TFs regulating RGS14 0 TFs

Transcription factors with Perturb-seq knockdown data for RGS14. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = RGS14 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.

Data: Effect:
TF Mean coef Binding Outlier TF→Gene link

Elements linked to RGS14

Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of RGS14, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.

Accessibility Element Dist. to TSS Link type TFs
chr5:177,083,311–177,083,887 283.7 kb Distal (>10kb) Multiome 69
chr5:177,086,049–177,087,797 280.5 kb Distal (>10kb) Multiome 867
chr5:177,116,759–177,117,326 250.3 kb Distal (>10kb) Multiome 369
chr5:177,131,498–177,134,721 233.7 kb Distal (>10kb) Multiome 724
chr5:177,303,008–177,304,238 63.6 kb Distal (>10kb) Multiome 850
chr5:177,309,549–177,310,172 57.5 kb Distal (>10kb) Multiome HiCAR 373
chr5:177,311,267–177,313,178 55.1 kb Distal (>10kb) Multiome HiCAR 798
chr5:177,351,374–177,352,243 15.4 kb Distal (>10kb) Multiome 832
chr5:177,362,756–177,363,624 4.1 kb Proximal (<10kb) Multiome 479
chr5:177,366,082–177,368,548 115 bp At TSS Multiome 626
chr5:177,370,255–177,371,449 3.6 kb Proximal (<10kb) Multiome 584
chr5:177,402,327–177,404,671 37.1 kb Distal (>10kb) Multiome 807
chr5:177,425,334–177,427,296 59.1 kb Distal (>10kb) Multiome HiCAR 982
chr5:177,446,196–177,448,203 79.5 kb Distal (>10kb) Multiome 826
chr5:177,453,910–177,456,838 88.2 kb Distal (>10kb) Multiome 1057
chr5:177,457,280–177,458,365 90.5 kb Distal (>10kb) Multiome 321
chr5:177,472,252–177,474,487 105.4 kb Distal (>10kb) Multiome 546
chr5:177,491,301–177,491,987 124.3 kb Distal (>10kb) Multiome 522
chr5:177,494,661–177,498,477 128.3 kb Distal (>10kb) Multiome 915
chr5:177,500,863–177,501,460 133.8 kb Distal (>10kb) Multiome 378
chr5:177,516,515–177,517,551 149.8 kb Distal (>10kb) Multiome 958
chr5:177,553,719–177,554,931 187.3 kb Distal (>10kb) Multiome 671
chr5:177,591,993–177,592,765 224.9 kb Distal (>10kb) Multiome 724
chr5:177,599,409–177,600,500 232.8 kb Distal (>10kb) Multiome 871
chr5:177,607,310–177,608,120 240.3 kb Distal (>10kb) Multiome 392

Genome Browser

Genomic view of the RGS14 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.

chr5:177,073,311 – 177,618,120
Proximal 1 kb Distal 10 kb Multiome HiCAR ATAC-seq RNA-seq
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