LMAN2

lectin, mannose binding 2 | GP36B, VIP36, C5orf8

This gene encodes a type I transmembrane lectin that shuttles between the endoplasmic reticulum, the Golgi apparatus and the plasma membrane. The encoded protein binds high mannose type glycoproteins and may facilitate their sorting, trafficking and quality control. [provided by RefSeq, Oct 2008]

Member of: DE-1

Biological processes 23 terms

COPII-coated ER to Golgi transport vesicle (GO:0030134)D-mannose binding (GO:0005537)D-mannose binding (GO:0005537)Golgi apparatus (GO:0005794)Golgi membrane (GO:0000139)Golgi membrane (GO:0000139)carbohydrate binding (GO:0030246)cell surface (GO:0009986)endoplasmic reticulum membrane (GO:0005789)endoplasmic reticulum membrane (GO:0005789)endoplasmic reticulum to Golgi vesicle-mediated transport (GO:0006888)endoplasmic reticulum-Golgi intermediate compartment (GO:0005793)endoplasmic reticulum-Golgi intermediate compartment (GO:0005793)endoplasmic reticulum-Golgi intermediate compartment membrane (GO:0033116)extracellular exosome (GO:0070062)extracellular region (GO:0005576)heat shock protein binding (GO:0031072)membrane (GO:0016020)plasma membrane (GO:0005886)positive regulation of phagocytosis (GO:0050766)positive regulation of phagocytosis (GO:0050766)protein binding (GO:0005515)retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum (GO:0006890)

Expression (TPM)

TFs regulating LMAN2 0 TFs

Transcription factors with Perturb-seq knockdown data for LMAN2. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = LMAN2 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.

TF	Mean coef	Binding	Outlier	TF→Gene link

Rows:

Elements linked to LMAN2

Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of LMAN2, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.

Element	Dist. to TSS	Link type	TFs
chr5:177,083,311–177,083,887	268.3 kb	Distal (>10kb) Multiome	69
chr5:177,086,049–177,087,797	265.0 kb	Distal (>10kb) Multiome	867
chr5:177,116,759–177,117,326	234.8 kb	Distal (>10kb) Multiome	369
chr5:177,131,498–177,134,721	218.2 kb	Distal (>10kb) Multiome	724
chr5:177,303,008–177,304,238	48.1 kb	Distal (>10kb) Multiome	850
chr5:177,309,549–177,310,172	42.0 kb	Distal (>10kb) Multiome	373
chr5:177,311,267–177,313,178	39.6 kb	Distal (>10kb) Multiome	798
chr5:177,351,374–177,352,243	26 bp	At TSS Multiome	832
chr5:177,362,756–177,363,624	11.4 kb	Distal (>10kb) Multiome	479
chr5:177,366,082–177,368,548	15.4 kb	Distal (>10kb) Multiome	626
chr5:177,370,255–177,371,449	19.0 kb	Distal (>10kb) Multiome	584
chr5:177,402,327–177,404,671	52.6 kb	Distal (>10kb) Multiome	807
chr5:177,425,334–177,427,296	74.6 kb	Distal (>10kb) Multiome	982
chr5:177,446,196–177,448,203	94.9 kb	Distal (>10kb) Multiome	826
chr5:177,453,910–177,456,838	103.7 kb	Distal (>10kb) Multiome	1057
chr5:177,457,280–177,458,365	106.0 kb	Distal (>10kb) Multiome	321
chr5:177,472,252–177,474,487	120.9 kb	Distal (>10kb) Multiome	546
chr5:177,491,301–177,491,987	139.8 kb	Distal (>10kb) Multiome	522
chr5:177,494,661–177,498,477	143.8 kb	Distal (>10kb) Multiome	915
chr5:177,500,863–177,501,460	149.3 kb	Distal (>10kb) Multiome	378
chr5:177,516,515–177,517,551	165.2 kb	Distal (>10kb) Multiome	958
chr5:177,553,719–177,554,931	202.7 kb	Distal (>10kb) Multiome	671
chr5:177,591,993–177,592,765	240.4 kb	Distal (>10kb) Multiome	724
chr5:177,599,409–177,600,500	248.2 kb	Distal (>10kb) Multiome	871
chr5:177,607,310–177,608,120	255.8 kb	Distal (>10kb) Multiome	392

Genome Browser

Genomic view of the LMAN2 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.