The protein encoded by this gene is a nucleolar, zinc finger protein that preferentially binds to double-stranded (ds) RNA or RNA/DNA hybrids, rather than DNA alone. Mutational studies indicate that the zinc finger domains are not only essential for dsRNA binding, but are also required for its nucleolar localization. The encoded protein may be involved in cell growth and survival. It plays a role in protecting neurons by inhibiting cell cycle re-entry via stimulation of p21 gene expression. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Apr 2015]
Transcription factors with Perturb-seq knockdown data for ZNF346. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ZNF346 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ZNF346, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr5:176,809,543–176,810,815 | 212.4 kb | Distal (>10kb) Multiome HiCAR | 404 | |
| chr5:176,817,316–176,818,386 | 204.7 kb | Distal (>10kb) Multiome HiCAR | 358 | |
| chr5:176,866,834–176,867,401 | 155.6 kb | Distal (>10kb) Multiome | 90 | |
| chr5:176,938,324–176,938,817 | 84.0 kb | Distal (>10kb) Multiome | 37 | |
| chr5:177,005,819–177,007,175 | 16.0 kb | Distal (>10kb) Multiome | 972 | |
| chr5:177,022,405–177,023,229 | 10 bp | At TSS Multiome | 767 | |
| chr5:177,083,311–177,083,887 | 60.9 kb | Distal (>10kb) Multiome | 69 | |
| chr5:177,086,049–177,087,797 | 64.1 kb | Distal (>10kb) Multiome | 867 | |
| chr5:177,116,759–177,117,326 | 94.3 kb | Distal (>10kb) Multiome | 369 | |
| chr5:177,131,498–177,134,721 | 110.9 kb | Distal (>10kb) Multiome | 724 | |
| chr5:177,303,008–177,304,238 | 281.0 kb | Distal (>10kb) Multiome | 850 | |
| chr5:177,309,549–177,310,172 | 287.1 kb | Distal (>10kb) Multiome | 373 | |
| chr5:177,311,267–177,313,178 | 289.5 kb | Distal (>10kb) Multiome | 798 |
Genomic view of the ZNF346 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.