chr5:95,876,461–95,877,373

chr5 : 95,876,461 – 95,877,373

912 bp 102 TFs 8 linked genes

This 912 bp open chromatin element is linked to 8 target genes and is bound by 102 transcription factors.

Linked Genes

8 genes

Gene	Expression	Dist. to TSS	Distance	Link type
GLRX		54.1 kb	Distal	Multiome
ELL2		85.0 kb	Distal	Multiome+HiCAR
ENSG00000251314		85.2 kb	Distal	Multiome+HiCAR
ENSG00000250240		144.5 kb	Distal	Multiome
RHOBTB3		145.5 kb	Distal	Multiome
SPATA9		178.1 kb	Distal	Multiome
RFESD		230.0 kb	Distal	Multiome
ENSG00000289337		295.2 kb	Distal	Multiome+HiCAR

Chromatin Accessibility

Genome Browser

Genomic view centred on this element. Tracks include ATAC-seq accessibility, RNA-seq expression, TF binding peaks, and element-to-gene loop arcs across the ESC → DE time course.

Transcription factors with ChIP-seq peak overlap or TOBIAS motif footprint evidence at this element.

TF Binding

102 transcription factors

ChIP HepG2 ENCFF252VFI 66 bp overlap

BARX1 1 dataset

Motif DE_60h DE_60h-BARX1_MA0875.2 6 bp overlap

ChIP SUM159PT_100nMtrametinib_24h GSE87418.BRD4.SUM159PT_100nMtrametinib_24h 370 bp overlap

Motif DE_60h DE_60h-BSX_MA0876.2 6 bp overlap

Motif DE_60h DE_60h-DLX1_MA0879.3 6 bp overlap

Motif DE_60h DE_60h-DLX6_MA0882.2 6 bp overlap

Motif DE_60h DE_60h-Dlx2_MA0885.3 8 bp overlap

Motif DE_60h DE_60h-Dlx3_MA0880.2 6 bp overlap

Motif DE_60h DE_60h-Dlx4_MA0881.2 6 bp overlap

Motif DE_60h DE_60h-Dlx5_MA1476.3 8 bp overlap

EOMES 1 dataset

ChIP hESC GSE26097.EOMES.hESC 207 bp overlap

ERF::FOXO1 1 dataset

Motif DE_60h DE_60h-ERFFOXO1_MA1936.2 12 bp overlap

EZH1 2 datasets

ChIP ProEs GSE59087.EZH1.ProEs 179 bp overlap

ChIP ProEs_SHCTR GSE59087.EZH1.ProEs_SHCTR 216 bp overlap

Motif DE_60h DE_60h-Elf5_MA0136.4 8 bp overlap

FIGLA 1 dataset

Motif DE_60h DE_60h-FIGLA_MA0820.2 6 bp overlap

FOXA1 3 datasets

ChIP breast-cancer_Veh-2856 GSE128018.FOXA1.breast-cancer_Veh-2856 198 bp overlap

ChIP breast-cancer_Veh-2856 GSE128018.FOXA1.breast-cancer_Veh-2856 203 bp overlap

ChIP pancreatic-progenitor_PP1 GSE104840.FOXA1.pancreatic-progenitor_PP1 218 bp overlap

FOXA2 3 datasets

ChIP DE DE-FOXA2-1 648 bp overlap

ChIP DE DE-FOXA2-2 758 bp overlap

ChIP pancreatic-progenitor_PP1 GSE104840.FOXA2.pancreatic-progenitor_PP1 346 bp overlap

FOXC2 1 dataset

Motif DE_60h DE_60h-FOXC2_MA0846.2 11 bp overlap

FOXJ2::ELF1 1 dataset

Motif DE_60h DE_60h-FOXJ2ELF1_MA1952.2 11 bp overlap

FOXO1-PAX3 1 dataset

ChIP RH4_DMSO-6H GSE116344.FOXO1-PAX3.RH4_DMSO-6H 172 bp overlap

FOXO1::ELK1 1 dataset

Motif DE_60h DE_60h-FOXO1ELK1_MA1954.2 13 bp overlap

FOXO1::ELK3 1 dataset

Motif DE_60h DE_60h-FOXO1ELK3_MA1955.2 13 bp overlap

FOXO1::FLI1 1 dataset

Motif DE_60h DE_60h-FOXO1FLI1_MA1956.2 13 bp overlap

FOXP1 2 datasets

ChIP Hep-G2 ENCSR369YUK.FOXP1.Hep-G2 171 bp overlap

ChIP HepG2 ENCFF823ERM 341 bp overlap

FOXS1 1 dataset

Motif DE_60h DE_60h-FOXS1_MA2118.1 8 bp overlap

Foxl2 1 dataset

Motif DE_60h DE_60h-Foxl2_MA1607.2 10 bp overlap

GATA4 8 datasets

ChIP DE DE-GATA4-1 510 bp overlap

ChIP DE DE-GATA4-2 805 bp overlap

Motif DE_48h DE_48h-GATA4_MA0482.3 8 bp overlap

Motif DE_60h DE_60h-GATA4_MA0482.3 8 bp overlap

Motif DE_72h DE_72h-GATA4_MA0482.3 8 bp overlap

ChIP foregut GSE117136.GATA4.foregut 695 bp overlap

ChIP pancreatic-progenitor GSE117136.GATA4.pancreatic-progenitor 550 bp overlap

ChIP pancreatic-progenitor_PP1 GSE104840.GATA4.pancreatic-progenitor_PP1 476 bp overlap

GATA5 3 datasets

Motif DE_48h DE_48h-GATA5_MA0766.3 8 bp overlap

Motif DE_60h DE_60h-GATA5_MA0766.3 8 bp overlap

Motif DE_72h DE_72h-GATA5_MA0766.3 8 bp overlap

GATA6 9 datasets

ChIP DE DE-GATA6-1 516 bp overlap

ChIP DE DE-GATA6-2 795 bp overlap

ChIP DE_D2 S55-DE-d2-GATA6-exp2 428 bp overlap

ChIP endoderm_KO GSE117136.GATA6.endoderm_KO 529 bp overlap

ChIP foregut GSE117136.GATA6.foregut 571 bp overlap

ChIP foregut_KO GSE117136.GATA6.foregut_KO 403 bp overlap

ChIP pancreatic-progenitor GSE117136.GATA6.pancreatic-progenitor 565 bp overlap

ChIP pancreatic-progenitor_KO GSE117136.GATA6.pancreatic-progenitor_KO 338 bp overlap

ChIP pancreatic-progenitor_PP1 GSE104840.GATA6.pancreatic-progenitor_PP1 414 bp overlap

Motif DE_60h DE_60h-GBX2_MA0890.2 6 bp overlap

HESX1 1 dataset

Motif DE_60h DE_60h-HESX1_MA0894.2 6 bp overlap

HIF1A 1 dataset

ChIP U2OS_trough_DMOG GSE85096.HIF1A.U2OS_trough_DMOG 401 bp overlap

HNF4A 1 dataset

ChIP liver ENCFF449HPV 57 bp overlap

HOXA5 1 dataset

Motif DE_60h DE_60h-HOXA5_MA0158.2 8 bp overlap

HOXA6 1 dataset

Motif DE_60h DE_60h-HOXA6_MA1497.2 7 bp overlap

HOXA7 1 dataset

Motif DE_60h DE_60h-HOXA7_MA1498.3 6 bp overlap

HOXB6 1 dataset

Motif DE_60h DE_60h-HOXB6_MA1500.2 7 bp overlap

HOXB7 1 dataset

Motif DE_60h DE_60h-HOXB7_MA1501.2 7 bp overlap

HOXB8 1 dataset

Motif DE_60h DE_60h-HOXB8_MA1502.2 7 bp overlap

HOXD8 1 dataset

Motif DE_60h DE_60h-HOXD8_MA0910.3 7 bp overlap

Motif DE_60h DE_60h-Hmx3_MA0898.2 9 bp overlap

IKZF1 1 dataset

Motif DE_60h DE_60h-IKZF1_MA1508.2 8 bp overlap

ChIP MDA-MB-231 GSE112444.JUN.MDA-MB-231 63 bp overlap

KDM1A 2 datasets

ChIP pancreatic-progenitor_PP1 GSE104840.KDM1A.pancreatic-progenitor_PP1 493 bp overlap

ChIP pancreatic-progenitor_PP2-KDM1A-inh GSE104840.KDM1A.pancreatic-progenitor_PP2-KDM1A-inh 309 bp overlap

Motif DE_60h DE_60h-LBX2_MA0699.2 6 bp overlap

Motif DE_60h DE_60h-LHX2_MA0700.3 6 bp overlap

MEIS1 3 datasets

Motif DE_36h DE_36h-MEIS1_MA0498.3 5 bp overlap

Motif DE_48h DE_48h-MEIS1_MA0498.3 5 bp overlap

Motif DE_60h DE_60h-MEIS1_MA0498.3 5 bp overlap

Motif DE_60h DE_60h-MSX1_MA0666.3 6 bp overlap

Motif DE_60h DE_60h-MSX2_MA0708.3 6 bp overlap

MYOD1 1 dataset

ChIP RD_shSNAI2 GSE137168.MYOD1.RD_shSNAI2 207 bp overlap

Motif DE_60h DE_60h-Msx3_MA0709.2 6 bp overlap

NCAPH2 1 dataset

ChIP IMR-90_FLAG_OIS GSE118494.NCAPH2.IMR-90_FLAG_OIS 894 bp overlap

NR2C2 2 datasets

Motif DE_48h DE_48h-NR2C2_MA0504.2 14 bp overlap

Motif DE_60h DE_60h-NR2C2_MA0504.2 14 bp overlap

NR2F1 2 datasets

Motif DE_48h DE_48h-NR2F1_MA1537.2 13 bp overlap

Motif DE_60h DE_60h-NR2F1_MA1537.2 13 bp overlap

Nfatc2 1 dataset

Motif DE_60h DE_60h-Nfatc2_MA0152.3 8 bp overlap

Nobox 1 dataset

Motif DE_60h DE_60h-Nobox_MA0125.2 6 bp overlap

Nr2f6 2 datasets

Motif DE_48h DE_48h-Nr2f6_MA0677.2 13 bp overlap

Motif DE_60h DE_60h-Nr2f6_MA0677.2 13 bp overlap

ChIP pancreatic-progenitor GSE117136.PDX1.pancreatic-progenitor 401 bp overlap

POU2F1 1 dataset

Motif DE_60h DE_60h-POU2F1_MA0785.2 9 bp overlap

POU2F2 1 dataset

Motif DE_60h DE_60h-POU2F2_MA0507.3 13 bp overlap

POU2F3 1 dataset

Motif DE_60h DE_60h-POU2F3_MA0627.3 9 bp overlap

POU3F2 1 dataset

Motif DE_60h DE_60h-POU3F2_MA0787.1 12 bp overlap

POU3F4 1 dataset

Motif DE_60h DE_60h-POU3F4_MA0789.1 9 bp overlap

POU5F1 2 datasets

Motif DE_60h DE_60h-POU5F1_MA1115.2 7 bp overlap

ChIP hESC_NAIVE GSE69646.POU5F1.hESC_NAIVE 527 bp overlap

POU5F1B 1 dataset

Motif DE_60h DE_60h-POU5F1B_MA0792.1 9 bp overlap

PPARD 2 datasets

Motif DE_48h DE_48h-PPARD_MA1550.2 14 bp overlap

Motif DE_60h DE_60h-PPARD_MA1550.2 14 bp overlap

Motif DE_60h DE_60h-RAX_MA0718.2 6 bp overlap

Motif DE_60h DE_60h-RBPJ_MA1116.2 6 bp overlap

RXRB 2 datasets

Motif DE_48h DE_48h-RXRB_MA0855.1 14 bp overlap

Motif DE_60h DE_60h-RXRB_MA0855.1 14 bp overlap

RXRG 2 datasets

Motif DE_48h DE_48h-RXRG_MA0856.1 14 bp overlap

Motif DE_60h DE_60h-RXRG_MA0856.1 14 bp overlap

Rfx6 3 datasets

Motif DE_48h DE_48h-Rfx6_MA1724.2 9 bp overlap

Motif DE_60h DE_60h-Rfx6_MA1724.2 9 bp overlap

Motif DE_72h DE_72h-Rfx6_MA1724.2 9 bp overlap

Rxra 2 datasets

Motif DE_48h DE_48h-Rxra_MA0512.2 14 bp overlap

Motif DE_60h DE_60h-Rxra_MA0512.2 14 bp overlap

SMAD2-3 2 datasets

ChIP HGrC1_WT GSE138496.SMAD2-3.HGrC1_WT 120 bp overlap

ChIP HUES-8_DE GSE109524.SMAD2-3.HUES-8_DE 338 bp overlap

SOX13 5 datasets

Motif DE_36h DE_36h-SOX13_MA1120.2 7 bp overlap

Motif DE_48h DE_48h-SOX13_MA1120.2 7 bp overlap

Motif DE_60h DE_60h-SOX13_MA1120.2 7 bp overlap

Motif DE_72h DE_72h-SOX13_MA1120.2 7 bp overlap

ChIP HepG2 ENCFF062VSQ 161 bp overlap

SOX14 4 datasets

Motif DE_36h DE_36h-SOX14_MA1562.2 9 bp overlap

Motif DE_48h DE_48h-SOX14_MA1562.2 9 bp overlap

Motif DE_60h DE_60h-SOX14_MA1562.2 9 bp overlap

Motif DE_72h DE_72h-SOX14_MA1562.2 9 bp overlap

SOX17 1 dataset

ChIP DE_D2 DED2-SOX17_Batch_II 309 bp overlap

SOX17_M 1 dataset

ChIP DE_D2 DED2-SOX17-M_Batch_II 499 bp overlap

SOX2 4 datasets

Motif DE_36h DE_36h-SOX2_MA0143.5 7 bp overlap

Motif DE_48h DE_48h-SOX2_MA0143.5 7 bp overlap

Motif DE_60h DE_60h-SOX2_MA0143.5 7 bp overlap

Motif DE_72h DE_72h-SOX2_MA0143.5 7 bp overlap

SOX4 4 datasets

Motif DE_36h DE_36h-SOX4_MA0867.3 8 bp overlap

Motif DE_48h DE_48h-SOX4_MA0867.3 8 bp overlap

Motif DE_60h DE_60h-SOX4_MA0867.3 8 bp overlap

Motif DE_72h DE_72h-SOX4_MA0867.3 8 bp overlap

ChIP Hep-G2 ENCSR766TSU.SOX6.Hep-G2 238 bp overlap

SOX8 4 datasets

Motif DE_36h DE_36h-SOX8_MA0868.3 7 bp overlap

Motif DE_48h DE_48h-SOX8_MA0868.3 7 bp overlap

Motif DE_60h DE_60h-SOX8_MA0868.3 7 bp overlap

Motif DE_72h DE_72h-SOX8_MA0868.3 7 bp overlap

SOX9 4 datasets

Motif DE_36h DE_36h-SOX9_MA0077.2 8 bp overlap

Motif DE_48h DE_48h-SOX9_MA0077.2 8 bp overlap

Motif DE_60h DE_60h-SOX9_MA0077.2 8 bp overlap

Motif DE_72h DE_72h-SOX9_MA0077.2 8 bp overlap

ChIP liver ENCFF597LFJ 124 bp overlap

Motif DE_36h DE_36h-SRY_MA0084.2 7 bp overlap

Motif DE_48h DE_48h-SRY_MA0084.2 7 bp overlap

Motif DE_60h DE_60h-SRY_MA0084.2 7 bp overlap

Motif DE_72h DE_72h-SRY_MA0084.2 7 bp overlap

Six3 3 datasets

Motif DE_36h DE_36h-Six3_MA0631.2 11 bp overlap

Motif DE_48h DE_48h-Six3_MA0631.2 11 bp overlap

Motif DE_60h DE_60h-Six3_MA0631.2 11 bp overlap

Sox11 1 dataset

Motif DE_60h DE_60h-Sox11_MA0869.3 8 bp overlap

Sox17 5 datasets

Motif DE_36h DE_36h-Sox17_MA0078.3 10 bp overlap

Motif DE_48h DE_48h-Sox17_MA0078.3 10 bp overlap

Motif DE_60h DE_60h-Sox17_MA0078.3 10 bp overlap

Motif DE_60h DE_60h-Sox17_MA0078.3 10 bp overlap

Motif DE_72h DE_72h-Sox17_MA0078.3 10 bp overlap

Sox3 4 datasets

Motif DE_36h DE_36h-Sox3_MA0514.3 7 bp overlap

Motif DE_48h DE_48h-Sox3_MA0514.3 7 bp overlap

Motif DE_60h DE_60h-Sox3_MA0514.3 7 bp overlap

Motif DE_72h DE_72h-Sox3_MA0514.3 7 bp overlap

Sox5 4 datasets

Motif DE_36h DE_36h-Sox5_MA0087.3 8 bp overlap

Motif DE_48h DE_48h-Sox5_MA0087.3 8 bp overlap

Motif DE_60h DE_60h-Sox5_MA0087.3 8 bp overlap

Motif DE_72h DE_72h-Sox5_MA0087.3 8 bp overlap

Sox6 5 datasets

Motif DE_36h DE_36h-Sox6_MA0515.1 10 bp overlap

Motif DE_48h DE_48h-Sox6_MA0515.1 10 bp overlap

Motif DE_60h DE_60h-Sox6_MA0515.1 10 bp overlap

Motif DE_60h DE_60h-Sox6_MA0515.1 10 bp overlap

Motif DE_72h DE_72h-Sox6_MA0515.1 10 bp overlap

Sox7 5 datasets

Motif DE_36h DE_36h-Sox7_MA2095.1 10 bp overlap

Motif DE_48h DE_48h-Sox7_MA2095.1 10 bp overlap

Motif DE_60h DE_60h-Sox7_MA2095.1 10 bp overlap

Motif DE_60h DE_60h-Sox7_MA2095.1 10 bp overlap

Motif DE_72h DE_72h-Sox7_MA2095.1 10 bp overlap

Motif DE_60h DE_60h-TCF4_MA0830.3 8 bp overlap

TFAP2A 1 dataset

ChIP WA09 GSE105081.TFAP2A.WA09 406 bp overlap

THRB 5 datasets

Motif DE_48h DE_48h-THRB_MA1574.2 13 bp overlap

Motif DE_48h DE_48h-THRB_MA1576.2 18 bp overlap

Motif DE_60h DE_60h-THRB_MA1574.2 13 bp overlap

Motif DE_60h DE_60h-THRB_MA1576.2 18 bp overlap

Motif DE_72h DE_72h-THRB_MA1576.2 18 bp overlap

TRIM28 1 dataset

ChIP WIBR3_NAIVE GSE84382.TRIM28.WIBR3_NAIVE 145 bp overlap

Motif DE_60h DE_60h-ZEB1_MA0103.4 6 bp overlap

ZKSCAN3 3 datasets

Motif DE_48h DE_48h-ZKSCAN3_MA1973.2 14 bp overlap

Motif DE_60h DE_60h-ZKSCAN3_MA1973.2 14 bp overlap

Motif DE_72h DE_72h-ZKSCAN3_MA1973.2 14 bp overlap

ZNF213 2 datasets

Motif DE_48h DE_48h-ZNF213_MA2121.1 12 bp overlap

Motif DE_60h DE_60h-ZNF213_MA2121.1 12 bp overlap

ZNF324 3 datasets

Motif DE_48h DE_48h-ZNF324_MA1977.2 14 bp overlap

Motif DE_60h DE_60h-ZNF324_MA1977.2 14 bp overlap

Motif DE_72h DE_72h-ZNF324_MA1977.2 14 bp overlap

ZNF341 3 datasets

Motif DE_48h DE_48h-ZNF341_MA1655.2 8 bp overlap

Motif DE_60h DE_60h-ZNF341_MA1655.2 8 bp overlap

Motif DE_72h DE_72h-ZNF341_MA1655.2 8 bp overlap

ZNF93 2 datasets

Motif DE_48h DE_48h-ZNF93_MA1721.2 14 bp overlap

Motif DE_60h DE_60h-ZNF93_MA1721.2 14 bp overlap

ZSCAN4 3 datasets

Motif DE_48h DE_48h-ZSCAN4_MA1155.1 15 bp overlap

Motif DE_60h DE_60h-ZSCAN4_MA1155.1 15 bp overlap

Motif DE_72h DE_72h-ZSCAN4_MA1155.1 15 bp overlap