Enables ATP binding activity; ATP hydrolysis activity; and small GTPase binding activity. Involved in retrograde transport, endosome to Golgi. Located in extracellular exosome. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for RHOBTB3. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = RHOBTB3 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of RHOBTB3, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr5:95,439,846–95,441,190 | 291.1 kb | Distal (>10kb) Multiome | 213 | |
| chr5:95,554,418–95,555,610 | 176.3 kb | Distal (>10kb) Multiome | 886 | |
| chr5:95,619,877–95,621,756 | 110.0 kb | Distal (>10kb) Multiome | 693 | |
| chr5:95,646,204–95,647,493 | 84.5 kb | Distal (>10kb) Multiome HiCAR | 938 | |
| chr5:95,668,883–95,670,237 | 61.7 kb | Distal (>10kb) Multiome HiCAR | 232 | |
| chr5:95,707,140–95,707,835 | 23.7 kb | Distal (>10kb) Multiome | 297 | |
| chr5:95,710,009–95,710,708 | 20.9 kb | Distal (>10kb) Multiome | 190 | |
| chr5:95,710,983–95,712,019 | 19.7 kb | Distal (>10kb) Multiome | 238 | |
| chr5:95,723,627–95,723,878 | 7.5 kb | Proximal (<10kb) | 238 | |
| chr5:95,727,894–95,728,271 | 3.1 kb | Proximal (<10kb) | 220 | |
| chr5:95,728,537–95,729,160 | 2.2 kb | Proximal (<10kb) | 418 | |
| chr5:95,730,766–95,732,378 | 123 bp | At TSS Multiome | 1009 | |
| chr5:95,822,039–95,823,085 | 91.2 kb | Distal (>10kb) Multiome | 509 | |
| chr5:95,823,341–95,824,963 | 93.1 kb | Distal (>10kb) Multiome | 644 | |
| chr5:95,834,672–95,835,242 | 103.7 kb | Distal (>10kb) Multiome | 673 | |
| chr5:95,858,584–95,859,414 | 127.6 kb | Distal (>10kb) Multiome | 793 | |
| chr5:95,876,461–95,877,373 | 145.5 kb | Distal (>10kb) Multiome | 102 | |
| chr5:95,960,294–95,963,994 | 230.6 kb | Distal (>10kb) Multiome | 1028 |
Genomic view of the RHOBTB3 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.