Transcription factors with Perturb-seq knockdown data for ENSG00000289337. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ENSG00000289337 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ENSG00000289337, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr5:95,876,461–95,877,373 | 295.2 kb | Distal (>10kb) Multiome HiCAR | 102 | |
| chr5:95,960,294–95,963,994 | 210.1 kb | Distal (>10kb) Multiome | 1028 | |
| chr5:96,080,513–96,081,651 | 91.1 kb | Distal (>10kb) Multiome | 203 | |
| chr5:96,089,891–96,090,560 | 81.9 kb | Distal (>10kb) Multiome | 62 | |
| chr5:96,093,388–96,094,727 | 78.0 kb | Distal (>10kb) Multiome | 243 | |
| chr5:96,150,037–96,151,059 | 21.8 kb | Distal (>10kb) Multiome | 134 | |
| chr5:96,170,598–96,171,212 | 1.2 kb | Proximal (<10kb) Multiome | 86 | |
| chr5:96,171,780–96,172,635 | 130 bp | At TSS Multiome | 107 |
Genomic view of the ENSG00000289337 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.