This gene encodes a member of the glutaredoxin family. The encoded protein is a cytoplasmic enzyme catalyzing the reversible reduction of glutathione-protein mixed disulfides. This enzyme highly contributes to the antioxidant defense system. It is crucial for several signalling pathways by controlling the S-glutathionylation status of signalling mediators. It is involved in beta-amyloid toxicity and Alzheimer's disease. Multiple alternatively spliced transcript variants encoding the same protein have been identified. [provided by RefSeq, Aug 2011]
Transcription factors with Perturb-seq knockdown data for GLRX. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = GLRX upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of GLRX, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr5:95,554,418–95,555,610 | 267.7 kb | Distal (>10kb) Multiome | 886 | |
| chr5:95,619,877–95,621,756 | 201.4 kb | Distal (>10kb) Multiome | 693 | |
| chr5:95,646,204–95,647,493 | 175.9 kb | Distal (>10kb) Multiome HiCAR | 938 | |
| chr5:95,668,883–95,670,237 | 153.1 kb | Distal (>10kb) Multiome | 232 | |
| chr5:95,707,140–95,707,835 | 115.1 kb | Distal (>10kb) Multiome | 297 | |
| chr5:95,710,009–95,710,708 | 112.3 kb | Distal (>10kb) Multiome | 190 | |
| chr5:95,710,983–95,712,019 | 111.1 kb | Distal (>10kb) Multiome | 238 | |
| chr5:95,730,766–95,732,378 | 91.5 kb | Distal (>10kb) Multiome | 1009 | |
| chr5:95,822,039–95,823,085 | 191 bp | At TSS Multiome | 509 | |
| chr5:95,823,341–95,824,963 | 1.7 kb | Proximal (<10kb) Multiome | 644 | |
| chr5:95,834,672–95,835,242 | 12.3 kb | Distal (>10kb) Multiome | 673 | |
| chr5:95,858,584–95,859,414 | 36.2 kb | Distal (>10kb) Multiome | 793 | |
| chr5:95,876,461–95,877,373 | 54.1 kb | Distal (>10kb) Multiome | 102 | |
| chr5:95,960,294–95,963,994 | 139.2 kb | Distal (>10kb) Multiome | 1028 | |
| chr5:96,080,513–96,081,651 | 258.3 kb | Distal (>10kb) Multiome | 203 | |
| chr5:96,089,891–96,090,560 | 267.5 kb | Distal (>10kb) Multiome | 62 | |
| chr5:96,093,388–96,094,727 | 271.3 kb | Distal (>10kb) Multiome | 243 |
Genomic view of the GLRX locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.