Predicted to enable 2 iron, 2 sulfur cluster binding activity. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for RFESD. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = RFESD upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of RFESD, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr5:95,439,846–95,441,190 | 206.5 kb | Distal (>10kb) Multiome | 213 | |
| chr5:95,554,418–95,555,610 | 91.7 kb | Distal (>10kb) Multiome | 886 | |
| chr5:95,619,877–95,621,756 | 25.4 kb | Distal (>10kb) Multiome | 693 | |
| chr5:95,644,181–95,644,633 | 2.1 kb | Proximal (<10kb) | 212 | |
| chr5:95,646,204–95,647,493 | 46 bp | At TSS Multiome | 938 | |
| chr5:95,655,711–95,655,881 | 8.9 kb | Proximal (<10kb) | 51 | |
| chr5:95,668,883–95,670,237 | 22.8 kb | Distal (>10kb) Multiome | 232 | |
| chr5:95,707,140–95,707,835 | 60.8 kb | Distal (>10kb) Multiome | 297 | |
| chr5:95,710,009–95,710,708 | 63.6 kb | Distal (>10kb) Multiome HiCAR | 190 | |
| chr5:95,710,983–95,712,019 | 64.9 kb | Distal (>10kb) Multiome | 238 | |
| chr5:95,730,766–95,732,378 | 84.4 kb | Distal (>10kb) Multiome HiCAR | 1009 | |
| chr5:95,822,039–95,823,085 | 175.8 kb | Distal (>10kb) Multiome HiCAR | 509 | |
| chr5:95,823,341–95,824,963 | 177.7 kb | Distal (>10kb) Multiome HiCAR | 644 | |
| chr5:95,834,672–95,835,242 | 188.2 kb | Distal (>10kb) Multiome HiCAR | 673 | |
| chr5:95,858,584–95,859,414 | 212.2 kb | Distal (>10kb) Multiome HiCAR | 793 | |
| chr5:95,876,461–95,877,373 | 230.0 kb | Distal (>10kb) Multiome | 102 |
Genomic view of the RFESD locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.