Transcription factors with Perturb-seq knockdown data for ENSG00000251314. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ENSG00000251314 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ENSG00000251314, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr5:95,668,883–95,670,237 | 292.4 kb | Distal (>10kb) Multiome | 232 | |
| chr5:95,707,140–95,707,835 | 254.4 kb | Distal (>10kb) Multiome | 297 | |
| chr5:95,710,009–95,710,708 | 251.6 kb | Distal (>10kb) Multiome | 190 | |
| chr5:95,710,983–95,712,019 | 250.4 kb | Distal (>10kb) Multiome | 238 | |
| chr5:95,730,766–95,732,378 | 230.8 kb | Distal (>10kb) Multiome | 1009 | |
| chr5:95,822,039–95,823,085 | 139.5 kb | Distal (>10kb) Multiome | 509 | |
| chr5:95,823,341–95,824,963 | 137.6 kb | Distal (>10kb) Multiome | 644 | |
| chr5:95,834,672–95,835,242 | 127.0 kb | Distal (>10kb) Multiome | 673 | |
| chr5:95,858,584–95,859,414 | 103.1 kb | Distal (>10kb) Multiome | 793 | |
| chr5:95,876,461–95,877,373 | 85.2 kb | Distal (>10kb) Multiome HiCAR | 102 | |
| chr5:95,959,062–95,959,608 | 2.4 kb | Proximal (<10kb) | 279 | |
| chr5:95,960,294–95,963,994 | 31 bp | At TSS Multiome | 1028 | |
| chr5:96,080,513–96,081,651 | 119.0 kb | Distal (>10kb) Multiome HiCAR | 203 | |
| chr5:96,089,891–96,090,560 | 128.2 kb | Distal (>10kb) Multiome HiCAR | 62 | |
| chr5:96,093,388–96,094,727 | 132.1 kb | Distal (>10kb) Multiome HiCAR | 243 | |
| chr5:96,150,037–96,151,059 | 188.3 kb | Distal (>10kb) Multiome | 134 | |
| chr5:96,170,598–96,171,212 | 208.9 kb | Distal (>10kb) Multiome | 86 | |
| chr5:96,171,780–96,172,635 | 210.2 kb | Distal (>10kb) Multiome | 107 |
Genomic view of the ENSG00000251314 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.