chr4 : 154,740,341 – 154,741,031

690 bp 72 TFs 1 linked gene

This 690 bp open chromatin element is linked to LRAT and is bound by 72 transcription factors.

Linked Genes

1 gene

Gene	Expression	Dist. to TSS	Distance	Link type
LRAT		3.0 kb	Proximal	Proximity

Chromatin Accessibility

Genome Browser

Genomic view centred on this element. Tracks include ATAC-seq accessibility, RNA-seq expression, TF binding peaks, and element-to-gene loop arcs across the ESC → DE time course.

Transcription factors with ChIP-seq peak overlap or TOBIAS motif footprint evidence at this element.

TF Binding

72 transcription factors

AGO1 2 datasets

ChIP Hep-G2 ENCSR555ZMV.AGO1.Hep-G2 183 bp overlap

ChIP Hep-G2 GSE120104.AGO1.Hep-G2 183 bp overlap

AR 2 datasets

ChIP LNCaP_DHT GSE92347.AR.LNCaP_DHT 128 bp overlap

ChIP MDA-MB-453 ERP003503.AR.MDA-MB-453 136 bp overlap

ARNT::HIF1A 1 dataset

Motif DE_12h DE_12h-ARNTHIF1A_MA0259.2 5 bp overlap

ASCL1 2 datasets

Motif DE_12h DE_12h-ASCL1_MA1100.3 8 bp overlap

Motif DE_12h DE_12h-ASCL1_MA1631.2 9 bp overlap

BCOR 2 datasets

ChIP WA01 GSE104690.BCOR.WA01 326 bp overlap

ChIP WA01_RNF2-R GSE104690.BCOR.WA01_RNF2-R 602 bp overlap

BRD1 1 dataset

ChIP HUES-64 GSE104059.BRD1.HUES-64 222 bp overlap

BRD4 3 datasets

ChIP MDA-MB-157 ERP003925.BRD4.MDA-MB-157 308 bp overlap

ChIP MV4-11_DMSO GSE120715.BRD4.MV4-11_DMSO 141 bp overlap

ChIP retina_AB1-RB GSE86981.BRD4.retina_AB1-RB 188 bp overlap

CHD1 1 dataset

ChIP WA01 ENCSR000AQK.CHD1.WA01 227 bp overlap

E2F6 2 datasets

ChIP H1 ENCFF785DWK 451 bp overlap

ChIP WA01 ENCSR000BSI.E2F6.WA01 306 bp overlap

EGR4 1 dataset

Motif DE_12h DE_12h-EGR4_MA0733.2 11 bp overlap

ESR1 1 dataset

ChIP Ishikawa GSE99905.ESR1.Ishikawa 216 bp overlap

EZH2 8 datasets

ChIP GM23248 ENCSR131FFJ.EZH2.GM23248 129 bp overlap

ChIP GM23338 ENCSR045YHA.EZH2.GM23338 113 bp overlap

ChIP LNCaP-abl GSE39459.EZH2.LNCaP-abl 275 bp overlap

ChIP WA01 ENCSR000ASY.EZH2.WA01 643 bp overlap

ChIP astrocyte ENCSR000ARR.EZH2.astrocyte 240 bp overlap

ChIP endothelial cell of umbilical vein ENCFF539AKL 191 bp overlap

ChIP hepatocyte ENCFF552DZB 429 bp overlap

ChIP neural progenitor cell ENCFF472NFV 690 bp overlap

EZH2_phosphoT487 1 dataset

ChIP neural_progenitor ENCSR656MXA.EZH2_phosphoT487.neural_progenitor 456 bp overlap

FIGLA 1 dataset

Motif DE_12h DE_12h-FIGLA_MA0820.2 6 bp overlap

FLI1 1 dataset

ChIP TSU-1621MT GSE60477.FLI1.TSU-1621MT 216 bp overlap

GATA4 2 datasets

ChIP DE DE-GATA4-2 267 bp overlap

ChIP pancreatic-progenitor GSE117136.GATA4.pancreatic-progenitor 345 bp overlap

GATA6 5 datasets

ChIP DE_D1 S09-DE-d1-GATA6-exp1 199 bp overlap

ChIP DE_D2 S55-DE-d2-GATA6-exp2 206 bp overlap

ChIP HUES-8_DE_JNKi GSE109524.GATA6.HUES-8_DE_JNKi 110 bp overlap

ChIP HUES-8_DE_JNKi GSE109524.GATA6.HUES-8_DE_JNKi 383 bp overlap

ChIP HUES-8_DE_ctrl GSE109524.GATA6.HUES-8_DE_ctrl 201 bp overlap

GRHL2 1 dataset

ChIP OVCAR-3 GSE71018.GRHL2.OVCAR-3 136 bp overlap

Gli1 1 dataset

Motif DE_12h DE_12h-Gli1_MA1990.2 10 bp overlap

Gli2 1 dataset

Motif DE_12h DE_12h-Gli2_MA0734.4 9 bp overlap

HDAC2 1 dataset

ChIP WA01 ENCSR000AVB.HDAC2.WA01 171 bp overlap

HES7 1 dataset

Motif DE_12h DE_12h-HES7_MA0822.1 12 bp overlap

JARID2 3 datasets

ChIP MRC-5_IPS25_CTR GSE48515.JARID2.MRC-5_IPS25_CTR 550 bp overlap

ChIP MRC-5_IPS25_MEG3 GSE48515.JARID2.MRC-5_IPS25_MEG3 443 bp overlap

ChIP UTEIPS6 GSE48516.JARID2.UTEIPS6 316 bp overlap

JUN 3 datasets

ChIP DE_D2 S02-DE-d2-JUN-exp1 332 bp overlap

ChIP HUES-8_DE_ctrl GSE109524.JUN.HUES-8_DE_ctrl 299 bp overlap

ChIP MDA-BoM-1833 GSE112444.JUN.MDA-BoM-1833 308 bp overlap

KDM4A 1 dataset

ChIP WA01 ENCSR000AVC.KDM4A.WA01 144 bp overlap

KDM6B 1 dataset

ChIP CUTLL1 GSE56694.KDM6B.CUTLL1 180 bp overlap

L3MBTL2 1 dataset

ChIP K-562 ENCSR530XQI.L3MBTL2.K-562 526 bp overlap

MEIS1 1 dataset

Motif DE_12h DE_12h-MEIS1_MA0498.3 5 bp overlap

MEIS2 1 dataset

Motif DE_12h DE_12h-MEIS2_MA0774.1 8 bp overlap

MEIS3 1 dataset

Motif DE_12h DE_12h-MEIS3_MA0775.2 7 bp overlap

MYOD1 1 dataset

Motif DE_12h DE_12h-MYOD1_MA0499.3 9 bp overlap

NANOG 1 dataset

ChIP WA01_3IL ERP004238.NANOG.WA01_3IL 251 bp overlap

NELFE 1 dataset

ChIP K-562_NHS GSE112379.NELFE.K-562_NHS 152 bp overlap

NHLH1 1 dataset

Motif DE_12h DE_12h-NHLH1_MA0048.3 9 bp overlap

OGG1 2 datasets

ChIP HEK293 GSE89017.OGG1.HEK293 354 bp overlap

ChIP HEK293_15min GSE89017.OGG1.HEK293_15min 296 bp overlap

PBX3 1 dataset

Motif DE_12h DE_12h-PBX3_MA1114.2 11 bp overlap

PCGF1 1 dataset

ChIP WA01 GSE104690.PCGF1.WA01 523 bp overlap

PKNOX1 1 dataset

Motif DE_12h DE_12h-PKNOX1_MA0782.3 10 bp overlap

POU5F1 2 datasets

ChIP BG03 GSE21614.POU5F1.BG03 229 bp overlap

ChIP WA01_3IL ERP004238.POU5F1.WA01_3IL 209 bp overlap

POU5F1_M 1 dataset

ChIP DE_D1 DED1-OCT4-M_Batch_II 276 bp overlap

PRDM9 1 dataset

Motif DE_12h DE_12h-PRDM9_MA1723.2 20 bp overlap

RNF2 4 datasets

ChIP K-562 ENCSR138FUZ.RNF2.K-562 142 bp overlap

ChIP WA01 GSE104690.RNF2.WA01 318 bp overlap

ChIP WA01 ENCSR784VUY.RNF2.WA01 326 bp overlap

ChIP WA09_heat-shock GSE105028.RNF2.WA09_heat-shock 317 bp overlap

RYBP 1 dataset

ChIP WA01 GSE104690.RYBP.WA01 347 bp overlap

SATB1 1 dataset

ChIP MCF-10A_dHD GSE123292.SATB1.MCF-10A_dHD 129 bp overlap

SIN3A 1 dataset

ChIP H1 ENCFF042ZSL 339 bp overlap

SMAD2-3 2 datasets

ChIP HUES-8_DE GSE109524.SMAD2-3.HUES-8_DE 544 bp overlap

ChIP HUES-8_DE GSE109524.SMAD2-3.HUES-8_DE 91 bp overlap

SMARCA4 1 dataset

ChIP Aska-SS GSE108025.SMARCA4.Aska-SS 190 bp overlap

SMARCC1 1 dataset

ChIP Aska-SS GSE108025.SMARCC1.Aska-SS 143 bp overlap

SNAI1 1 dataset

Motif DE_12h DE_12h-SNAI1_MA1558.2 7 bp overlap

SNAI2 1 dataset

Motif DE_12h DE_12h-SNAI2_MA0745.3 8 bp overlap

SNAI3 1 dataset

Motif DE_12h DE_12h-SNAI3_MA1559.2 9 bp overlap

SREBP2 1 dataset

ChIP HCC70 GSE126380.SREBP2.HCC70 266 bp overlap

SUZ12 6 datasets

ChIP CRL-7250_shSS18-SSX GSE108025.SUZ12.CRL-7250_shSS18-SSX 276 bp overlap

ChIP H1 ENCFF881NFR 690 bp overlap

ChIP H1 ENCFF881NFR 579 bp overlap

ChIP K-562 ENCSR000AUC.SUZ12.K-562 179 bp overlap

ChIP NT2-D1 ENCSR000EXH.SUZ12.NT2-D1 107 bp overlap

ChIP hiPSC GSE124903.SUZ12.hiPSC 248 bp overlap

TBX15 1 dataset

Motif DE_12h DE_12h-TBX15_MA0803.1 8 bp overlap

TBX18 1 dataset

Motif DE_12h DE_12h-TBX18_MA1565.2 9 bp overlap

TBX4 1 dataset

Motif DE_12h DE_12h-TBX4_MA0806.1 8 bp overlap

TCF12 1 dataset

Motif DE_12h DE_12h-TCF12_MA1648.2 7 bp overlap

TCF3 1 dataset

Motif DE_12h DE_12h-TCF3_MA0522.4 7 bp overlap

TCF4 1 dataset

Motif DE_12h DE_12h-TCF4_MA0830.3 8 bp overlap

TFAP2A 1 dataset

Motif DE_12h DE_12h-TFAP2A_MA0810.2 11 bp overlap

TFAP2B 1 dataset

Motif DE_12h DE_12h-TFAP2B_MA0811.2 11 bp overlap

TFAP2C 3 datasets

Motif DE_12h DE_12h-TFAP2C_MA0524.3 11 bp overlap

ChIP UCLA1-hESCs_TFAP2C--_1d_TFAP2C_Induc GSE101074.TFAP2C.UCLA1-hESCs_TFAP2C--_1d_TFAP2C_Induc 367 bp overlap

ChIP UCLA1-hESCs_TFAP2C--_2d_TFAP2C_Induc GSE101074.TFAP2C.UCLA1-hESCs_TFAP2C--_2d_TFAP2C_Induc 381 bp overlap

TRIM25 1 dataset

ChIP BT-549 GSE79588.TRIM25.BT-549 199 bp overlap

ZBTB7B 1 dataset

Motif DE_12h DE_12h-ZBTB7B_MA0694.2 10 bp overlap

ZBTB7C 1 dataset

Motif DE_12h DE_12h-ZBTB7C_MA0695.2 8 bp overlap

ZEB1 1 dataset

Motif DE_12h DE_12h-ZEB1_MA0103.4 6 bp overlap

ZNF182 1 dataset

ChIP HEK293T GSE78099.ZNF182.HEK293T 143 bp overlap

ZNF24 1 dataset

Motif DE_12h DE_12h-ZNF24_MA1124.1 13 bp overlap

ZNF462 1 dataset

ChIP GM23338 ENCSR334UWP.ZNF462.GM23338 176 bp overlap

ZNF549 1 dataset

Motif DE_12h DE_12h-ZNF549_MA1728.2 8 bp overlap

ZNF675 1 dataset

Motif DE_12h DE_12h-ZNF675_MA1714.2 19 bp overlap

ZNF692 1 dataset

Motif DE_12h DE_12h-ZNF692_MA1986.2 8 bp overlap