chr4:55,675,062–55,675,981

chr4 : 55,675,062 – 55,675,981

919 bp 89 TFs 6 linked genes

This 919 bp open chromatin element is linked to 6 target genes and is bound by 89 transcription factors.

Linked Genes

6 genes

Gene	Expression	Dist. to TSS	Distance	Link type
NMU		39.2 kb	Distal	Multiome
PDCL2		83.2 kb	Distal	Multiome
CLOCK		128.6 kb	Distal	Multiome
EXOC1		178.2 kb	Distal	Multiome
CEP135		273.4 kb	Distal	Multiome
TMEM165		279.5 kb	Distal	Multiome

Chromatin Accessibility

Genome Browser

Genomic view centred on this element. Tracks include ATAC-seq accessibility, RNA-seq expression, TF binding peaks, and element-to-gene loop arcs across the ESC → DE time course.

Transcription factors with ChIP-seq peak overlap or TOBIAS motif footprint evidence at this element.

TF Binding

89 transcription factors

ASCL1 1 dataset

ChIP NCI-H889 GSE69394.ASCL1.NCI-H889 228 bp overlap

Ascl2 2 datasets

Motif DE_48h DE_48h-Ascl2_MA0816.1 10 bp overlap

Motif DE_72h DE_72h-Ascl2_MA0816.1 10 bp overlap

BHLHE22 2 datasets

Motif DE_48h DE_48h-BHLHE22_MA1635.2 6 bp overlap

Motif DE_72h DE_72h-BHLHE22_MA1635.2 6 bp overlap

BORCS8-MEF2B,MEF2B 1 dataset

ChIP GM12878 ENCFF427QAI 384 bp overlap

BRD4 3 datasets

ChIP NCI-H1963 GSE145028.BRD4.NCI-H1963 369 bp overlap

ChIP NCI-H1963_shASXL3 GSE145028.BRD4.NCI-H1963_shASXL3 263 bp overlap

ChIP hESC GSE33281.BRD4.hESC 76 bp overlap

Bach1::Mafk 2 datasets

Motif DE_48h DE_48h-Bach1Mafk_MA0591.2 12 bp overlap

Motif DE_72h DE_72h-Bach1Mafk_MA0591.2 12 bp overlap

CDX2 2 datasets

Motif DE_48h DE_48h-CDX2_MA0465.3 8 bp overlap

Motif DE_72h DE_72h-CDX2_MA0465.3 8 bp overlap

CTCF 4 datasets

ChIP K562 ENCFF082GOI 185 bp overlap

ChIP Kelly_resistant GSE103030.CTCF.Kelly_resistant 113 bp overlap

ChIP RH4 GSE83726.CTCF.RH4 231 bp overlap

ChIP leukemia GSE142161.CTCF.leukemia 254 bp overlap

Cebpa 3 datasets

ChIP BLaER1 ENCFF093OYK 261 bp overlap

ChIP BLaER1 ENCFF274GAT 251 bp overlap

ChIP BLaER1 ENCFF364PUR 190 bp overlap

ChIP K-562 ENCSR000EWJ.E2F6.K-562 189 bp overlap

EBF1 3 datasets

ChIP ASC GSE54889.EBF1.ASC 131 bp overlap

ChIP GM12878 ENCFF813OXE 265 bp overlap

ChIP NALM-6 GSE126300.EBF1.NALM-6 714 bp overlap

EOMES 2 datasets

Motif DE_72h DE_72h-EOMES_MA0800.2 9 bp overlap

ChIP hESC GSE26097.EOMES.hESC 396 bp overlap

ChIP MCF-7_E2 GSE14664.ESR1.MCF-7_E2 81 bp overlap

FOXA2 2 datasets

ChIP DE DE-FOXA2-1 555 bp overlap

ChIP DE DE-FOXA2-2 562 bp overlap

GATA4 2 datasets

ChIP DE DE-GATA4-1 753 bp overlap

ChIP DE DE-GATA4-2 724 bp overlap

GATA6 7 datasets

ChIP DE DE-GATA6-1 580 bp overlap

ChIP DE DE-GATA6-2 766 bp overlap

ChIP DE_D1 S14-DE-d1-GATA6-exp1 439 bp overlap

ChIP DE_D1 S41-DE-d1-GATA6-exp2 489 bp overlap

ChIP DE_D2 S55-DE-d2-GATA6-exp2 492 bp overlap

ChIP HUES-8_DE_JNKi GSE109524.GATA6.HUES-8_DE_JNKi 296 bp overlap

ChIP HUES-8_DE_ctrl GSE109524.GATA6.HUES-8_DE_ctrl 388 bp overlap

HDAC2 1 dataset

ChIP pre-B-cell GSE107886.HDAC2.pre-B-cell 343 bp overlap

IKZF1 2 datasets

ChIP K-562 ENCSR395HWC.IKZF1.K-562 267 bp overlap

ChIP pre-B-cell GSE107886.IKZF1.pre-B-cell 479 bp overlap

ChIP DE_D1 S40-DE-d1-JUN-exp2 392 bp overlap

ChIP DE_D2 S02-DE-d2-JUN-exp1 429 bp overlap

L3MBTL2 2 datasets

ChIP K-562 ENCSR530XQI.L3MBTL2.K-562 489 bp overlap

ChIP K562 ENCFF320EQC 601 bp overlap

Motif DE_48h DE_48h-MAF_MA1520.2 13 bp overlap

Motif DE_72h DE_72h-MAF_MA1520.2 13 bp overlap

MAFA 2 datasets

Motif DE_48h DE_48h-MAFA_MA1521.2 13 bp overlap

Motif DE_72h DE_72h-MAFA_MA1521.2 13 bp overlap

ChIP NCI-H2171 GSE36354.MAX.NCI-H2171 342 bp overlap

ChIP SGBS GSE64233.MED1.SGBS 203 bp overlap

MEF2B 1 dataset

ChIP GM12878 ENCSR177VFS.MEF2B.GM12878 573 bp overlap

Motif DE_72h DE_72h-MGA_MA0801.1 8 bp overlap

Motif DE_48h DE_48h-MSC_MA0665.1 10 bp overlap

Motif DE_72h DE_72h-MSC_MA0665.1 10 bp overlap

ChIP RH4 GSE155861.MTA2.RH4 221 bp overlap

MYOD1 1 dataset

ChIP RH4 GSE83726.MYOD1.RH4 307 bp overlap

MYOG 2 datasets

Motif DE_48h DE_48h-MYOG_MA0500.3 8 bp overlap

Motif DE_72h DE_72h-MYOG_MA0500.3 8 bp overlap

Mafg 2 datasets

Motif DE_48h DE_48h-Mafg_MA0659.4 12 bp overlap

Motif DE_72h DE_72h-Mafg_MA0659.4 12 bp overlap

NFATC3 2 datasets

Motif DE_48h DE_48h-NFATC3_MA0625.3 6 bp overlap

Motif DE_72h DE_72h-NFATC3_MA0625.3 6 bp overlap

NHLH1 2 datasets

Motif DE_48h DE_48h-NHLH1_MA0048.3 9 bp overlap

Motif DE_72h DE_72h-NHLH1_MA0048.3 9 bp overlap

NR3C1 2 datasets

ChIP SUP-B15_DEX GSE107584.NR3C1.SUP-B15_DEX 452 bp overlap

ChIP U2OS_SHHIC5 GSE65847.NR3C1.U2OS_SHHIC5 554 bp overlap

Neurod2 2 datasets

Motif DE_48h DE_48h-Neurod2_MA1993.2 6 bp overlap

Motif DE_72h DE_72h-Neurod2_MA1993.2 6 bp overlap

Nfatc1 2 datasets

Motif DE_48h DE_48h-Nfatc1_MA0624.3 6 bp overlap

Motif DE_72h DE_72h-Nfatc1_MA0624.3 6 bp overlap

Nr1h3::Rxra 2 datasets

Motif DE_48h DE_48h-Nr1h3Rxra_MA0494.2 16 bp overlap

Motif DE_72h DE_72h-Nr1h3Rxra_MA0494.2 16 bp overlap

Olig2 2 datasets

Motif DE_48h DE_48h-Olig2_MA1997.2 6 bp overlap

Motif DE_72h DE_72h-Olig2_MA1997.2 6 bp overlap

ChIP NALM-6 GSE126300.PAX5.NALM-6 253 bp overlap

PPARG 1 dataset

ChIP SGBS GSE41629.PPARG.SGBS 222 bp overlap

PRDM1 2 datasets

Motif DE_48h DE_48h-PRDM1_MA0508.4 7 bp overlap

Motif DE_72h DE_72h-PRDM1_MA0508.4 7 bp overlap

RAD21 1 dataset

ChIP RH4 GSE83726.RAD21.RH4 271 bp overlap

RBPJ 3 datasets

ChIP NHEK GSE29498.RBPJ.NHEK 129 bp overlap

ChIP NHEK GSE29498.RBPJ.NHEK 116 bp overlap

ChIP NHEK GSE29498.RBPJ.NHEK 153 bp overlap

RUNX1 2 datasets

ChIP 697 GSE138031.RUNX1.697 291 bp overlap

ChIP NALM-6 GSE126300.RUNX1.NALM-6 742 bp overlap

Motif DE_72h DE_72h-SIX1_MA1118.2 9 bp overlap

Motif DE_72h DE_72h-SIX2_MA1119.2 11 bp overlap

SMAD2 3 datasets

Motif DE_48h DE_48h-SMAD2_MA1964.2 6 bp overlap

Motif DE_72h DE_72h-SMAD2_MA1964.2 6 bp overlap

ChIP endoderm GSE29422.SMAD2.endoderm 215 bp overlap

SMAD2-3 3 datasets

ChIP HUES-8_DE GSE109524.SMAD2-3.HUES-8_DE 642 bp overlap

ChIP HUES-8_DE_JNKi GSE109524.SMAD2-3.HUES-8_DE_JNKi 618 bp overlap

ChIP HUES-8_DE_ctrl GSE109524.SMAD2-3.HUES-8_DE_ctrl 559 bp overlap

SMAD2_3 5 datasets

ChIP DE_D1 S07-DE-d1-SMAD2_3-exp1 657 bp overlap

ChIP DE_D1 S12-DE-d1-SMAD2_3-exp1 636 bp overlap

ChIP DE_D1 S39-DE-d1-SMAD2_3-exp2 692 bp overlap

ChIP DE_D2 S01-DE-d2-SMAD2_3-exp1 636 bp overlap

ChIP DE_D2 S53-DE-d2-SMAD2_3-exp2 585 bp overlap

SMAD3 2 datasets

ChIP BG03_DIFF_48H GSE36578.SMAD3.BG03_DIFF_48H 136 bp overlap

ChIP endoderm GSE29422.SMAD3.endoderm 172 bp overlap

SMARCA4 1 dataset

ChIP hiPSC GSE124903.SMARCA4.hiPSC 384 bp overlap

SMARCB1 1 dataset

ChIP hiPSC GSE124903.SMARCB1.hiPSC 181 bp overlap

SMARCC1 1 dataset

ChIP DE_D1 S15-DE-d1-BAF155-exp1 678 bp overlap

ChIP NHEK GSE29498.SND1.NHEK 163 bp overlap

SOX17_M 1 dataset

ChIP DE_D2 DED2-SOX17-M_Batch_II 486 bp overlap

Motif DE_48h DE_48h-SP5_MA1965.2 6 bp overlap

Motif DE_72h DE_72h-SP5_MA1965.2 6 bp overlap

Motif DE_72h DE_72h-SP5_MA1965.2 6 bp overlap

STAT3 2 datasets

Motif DE_48h DE_48h-STAT3_MA0144.3 9 bp overlap

Motif DE_72h DE_72h-STAT3_MA0144.3 9 bp overlap

Stat4 4 datasets

Motif DE_48h DE_48h-Stat4_MA0518.2 10 bp overlap

Motif DE_48h DE_48h-Stat4_MA0518.2 10 bp overlap

Motif DE_72h DE_72h-Stat4_MA0518.2 10 bp overlap

Motif DE_72h DE_72h-Stat4_MA0518.2 10 bp overlap

ChIP H9_ENDODERM GSE60606.T.H9_ENDODERM 179 bp overlap

ChIP H9_MESODERM GSE60606.T.H9_MESODERM 320 bp overlap

Motif DE_72h DE_72h-TBR1_MA0802.2 9 bp overlap

Motif DE_72h DE_72h-TBX1_MA0805.1 8 bp overlap

TBX15 1 dataset

Motif DE_72h DE_72h-TBX15_MA0803.1 8 bp overlap

TBX18 1 dataset

Motif DE_72h DE_72h-TBX18_MA1565.2 9 bp overlap

Motif DE_72h DE_72h-TBX2_MA0688.2 9 bp overlap

TBX20 1 dataset

Motif DE_72h DE_72h-TBX20_MA0689.1 11 bp overlap

TBX21 1 dataset

Motif DE_72h DE_72h-TBX21_MA0690.3 10 bp overlap

Motif DE_72h DE_72h-TBX3_MA1566.3 9 bp overlap

Motif DE_72h DE_72h-TBX4_MA0806.1 8 bp overlap

Motif DE_72h DE_72h-TBX5_MA0807.1 8 bp overlap

ChIP RCH-ACV GSE85988.TCF3.RCH-ACV 487 bp overlap

ChIP SaOS-2 GSE15780.TP53.SaOS-2 222 bp overlap

TRIM28 1 dataset

ChIP hESC GSE115387.TRIM28.hESC 280 bp overlap

Motif DE_72h DE_72h-Tbx6_MA1567.3 9 bp overlap

Tcf12 2 datasets

Motif DE_48h DE_48h-Tcf12_MA0521.3 6 bp overlap

Motif DE_72h DE_72h-Tcf12_MA0521.3 6 bp overlap

Twist2 2 datasets

Motif DE_48h DE_48h-Twist2_MA0633.3 6 bp overlap

Motif DE_72h DE_72h-Twist2_MA0633.3 6 bp overlap

Motif DE_48h DE_48h-Wt1_MA1627.2 10 bp overlap

Motif DE_72h DE_72h-Wt1_MA1627.2 10 bp overlap

ChIP RH4_DMSO-6H GSE116344.YY1.RH4_DMSO-6H 267 bp overlap

ZFP36 2 datasets

ChIP K-562 ENCSR776CYN.ZFP36.K-562 181 bp overlap

ChIP K562 ENCFF255RZG 297 bp overlap

ZIC1 2 datasets

Motif DE_48h DE_48h-ZIC1_MA0696.1 14 bp overlap

Motif DE_72h DE_72h-ZIC1_MA0696.1 14 bp overlap

ChIP HEK293 ENCFF033NQQ 217 bp overlap

ZIC4 2 datasets

Motif DE_48h DE_48h-ZIC4_MA0751.2 14 bp overlap

Motif DE_72h DE_72h-ZIC4_MA0751.2 14 bp overlap

ZIC5 2 datasets

Motif DE_48h DE_48h-ZIC5_MA1584.2 15 bp overlap

Motif DE_72h DE_72h-ZIC5_MA1584.2 15 bp overlap

ZNF316 1 dataset

ChIP K562 ENCFF838QCD 317 bp overlap

ZNF547 1 dataset

Motif DE_72h DE_72h-ZNF547_MA2334.1 13 bp overlap

ZNF549 2 datasets

Motif DE_48h DE_48h-ZNF549_MA1728.2 8 bp overlap

Motif DE_72h DE_72h-ZNF549_MA1728.2 8 bp overlap

ZSCAN31 2 datasets

Motif DE_48h DE_48h-ZSCAN31_MA1722.2 18 bp overlap

Motif DE_72h DE_72h-ZSCAN31_MA1722.2 18 bp overlap

Zic1::Zic2 2 datasets

Motif DE_48h DE_48h-Zic1Zic2_MA1628.2 7 bp overlap

Motif DE_72h DE_72h-Zic1Zic2_MA1628.2 7 bp overlap

Zic2 2 datasets

Motif DE_48h DE_48h-Zic2_MA1629.2 9 bp overlap

Motif DE_72h DE_72h-Zic2_MA1629.2 9 bp overlap

Zic3 2 datasets

Motif DE_48h DE_48h-Zic3_MA0697.3 7 bp overlap

Motif DE_72h DE_72h-Zic3_MA0697.3 7 bp overlap