This gene encodes a member of the phosducin-like protein family and is a putative modulator of heterotrimeric G proteins. The protein shares extensive amino acid sequence homology with phosducin. Members of the phosducin-like protein family have been shown to bind to the beta-gamma subunits of G proteins. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for PDCL2. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = PDCL2 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of PDCL2, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr4:55,346,084–55,347,178 | 245.9 kb | Distal (>10kb) Multiome | 874 | |
| chr4:55,395,297–55,396,739 | 196.4 kb | Distal (>10kb) Multiome | 882 | |
| chr4:55,545,595–55,547,586 | 45.4 kb | Distal (>10kb) Multiome | 933 | |
| chr4:55,588,236–55,588,523 | 3.7 kb | Proximal (<10kb) | 17 | |
| chr4:55,635,259–55,636,954 | 44.0 kb | Distal (>10kb) Multiome | 468 | |
| chr4:55,675,062–55,675,981 | 83.2 kb | Distal (>10kb) Multiome | 89 | |
| chr4:55,676,969–55,678,075 | 85.1 kb | Distal (>10kb) Multiome | 12 | |
| chr4:55,853,417–55,854,168 | 261.4 kb | Distal (>10kb) Multiome | 698 |
Genomic view of the PDCL2 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.