This gene encodes a centrosomal protein, which acts as a scaffolding protein during early centriole biogenesis, and is also required for centriole-centriole cohesion during interphase. Mutations in this gene are associated with autosomal recessive primary microcephaly-8. [provided by RefSeq, Jun 2012]
Transcription factors with Perturb-seq knockdown data for CEP135. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = CEP135 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of CEP135, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr4:55,675,062–55,675,981 | 273.4 kb | Distal (>10kb) Multiome | 89 | |
| chr4:55,676,969–55,678,075 | 271.5 kb | Distal (>10kb) Multiome | 12 | |
| chr4:55,853,417–55,854,168 | 95.2 kb | Distal (>10kb) Multiome | 698 | |
| chr4:55,948,442–55,949,600 | 40 bp | At TSS Multiome | 993 | |
| chr4:56,048,601–56,050,047 | 100.9 kb | Distal (>10kb) Multiome | 655 | |
| chr4:56,055,093–56,055,833 | 106.5 kb | Distal (>10kb) Multiome | 115 |
Genomic view of the CEP135 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.