This gene encodes a member of the neuromedin family of neuropeptides. The encoded protein is a precursor that is proteolytically processed to generate a biologically active neuropeptide that plays a role in pain, stress, immune-mediated inflammatory diseases and feeding regulation. Increased expression of this gene was observed in renal, pancreatic and lung cancers. Alternative splicing results in multiple transcript variants encoding different isoforms. Some of these isoforms may undergo similar processing to generate the mature peptide. [provided by RefSeq, Jul 2015]
Transcription factors with Perturb-seq knockdown data for NMU. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = NMU upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of NMU, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr4:55,346,084–55,347,178 | 289.9 kb | Distal (>10kb) Multiome | 874 | |
| chr4:55,395,297–55,396,739 | 240.4 kb | Distal (>10kb) Multiome | 882 | |
| chr4:55,545,595–55,547,586 | 89.5 kb | Distal (>10kb) Multiome | 933 | |
| chr4:55,635,259–55,636,954 | 31 bp | At TSS Multiome | 468 | |
| chr4:55,637,272–55,637,459 | 974 bp | At TSS | 87 | |
| chr4:55,675,062–55,675,981 | 39.2 kb | Distal (>10kb) Multiome | 89 | |
| chr4:55,676,969–55,678,075 | 41.0 kb | Distal (>10kb) Multiome | 12 | |
| chr4:55,853,417–55,854,168 | 217.4 kb | Distal (>10kb) Multiome | 698 |
Genomic view of the NMU locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.