chr2:207,905,345–207,906,166

chr2 : 207,905,345 – 207,906,166

821 bp 83 TFs 6 linked genes

This 821 bp open chromatin element is linked to 6 target genes and is bound by 83 transcription factors.

Linked Genes

6 genes

Gene	Expression	Dist. to TSS	Distance	Link type
PLEKHM3		119.8 kb	Distal	Multiome
FZD5		135.8 kb	Distal	Multiome+HiCAR
ENSG00000272851		151.3 kb	Distal	Multiome
CCNYL1		194.2 kb	Distal	Multiome
ENSG00000290929		206.9 kb	Distal	Multiome
METTL21A		280.3 kb	Distal	Multiome

Chromatin Accessibility

Genome Browser

Genomic view centred on this element. Tracks include ATAC-seq accessibility, RNA-seq expression, TF binding peaks, and element-to-gene loop arcs across the ESC → DE time course.

Transcription factors with ChIP-seq peak overlap or TOBIAS motif footprint evidence at this element.

TF Binding

83 transcription factors

ChIP metastatic-neuroblastoma_SKNMM GSE100148.ATRX.metastatic-neuroblastoma_SKNMM 625 bp overlap

BRD4 6 datasets

ChIP Kelly_resistant GSE103030.BRD4.Kelly_resistant 274 bp overlap

ChIP Kelly_resistant_JQ1 GSE103030.BRD4.Kelly_resistant_JQ1 400 bp overlap

ChIP Kelly_sensitive GSE103030.BRD4.Kelly_sensitive 709 bp overlap

ChIP SK-N-BE2-C_Naive-veh GSE107706.BRD4.SK-N-BE2-C_Naive-veh 289 bp overlap

ChIP SK-N-BE2-C_Resistant-veh GSE107706.BRD4.SK-N-BE2-C_Resistant-veh 473 bp overlap

ChIP hESC GSE33281.BRD4.hESC 61 bp overlap

ChIP LS180 GSE31939.CDX2.LS180 121 bp overlap

CREB1 1 dataset

ChIP A-549 ENCSR000BRC.CREB1.A-549 143 bp overlap

ChIP retina_Hu3 GSE137311.CRX.retina_Hu3 285 bp overlap

ChIP retina_Hu6 GSE137311.CRX.retina_Hu6 368 bp overlap

CTCFL 1 dataset

ChIP Kelly_resistant_JQ1 GSE103030.CTCFL.Kelly_resistant_JQ1 241 bp overlap

EOMES 1 dataset

ChIP hESC GSE26097.EOMES.hESC 337 bp overlap

ESR1 2 datasets

Motif DE_36h DE_36h-ESR1_MA0112.4 15 bp overlap

Motif DE_60h DE_60h-ESR1_MA0112.4 15 bp overlap

ChIP neural progenitor cell ENCFF018MKA 214 bp overlap

EZH2_phosphoT487 1 dataset

ChIP neural_progenitor ENCSR656MXA.EZH2_phosphoT487.neural_progenitor 330 bp overlap

FOXA1 1 dataset

ChIP HepG2 ENCFF207NVJ 281 bp overlap

FOXA2 3 datasets

ChIP DE DE-FOXA2-1 757 bp overlap

ChIP DE DE-FOXA2-2 704 bp overlap

ChIP PANC-1_HNF1B-OE GSE119930.FOXA2.PANC-1_HNF1B-OE 319 bp overlap

FOXH1 1 dataset

Motif DE_36h DE_36h-FOXH1_MA0479.2 8 bp overlap

GATA2 2 datasets

ChIP SK-N-SH ENCFF764OZD 417 bp overlap

ChIP SK-N-SH ENCSR706VOO.GATA2.SK-N-SH 290 bp overlap

GATA3 3 datasets

ChIP Kelly GSE65664.GATA3.Kelly 417 bp overlap

ChIP Kelly GSE94822.GATA3.Kelly 346 bp overlap

ChIP SK-N-BE2-C GSE94822.GATA3.SK-N-BE2-C 233 bp overlap

GATA4 4 datasets

ChIP BJ1-hTERT GSE92491.GATA4.BJ1-hTERT 339 bp overlap

ChIP DE DE-GATA4-1 748 bp overlap

ChIP DE DE-GATA4-2 821 bp overlap

ChIP pancreatic-progenitor GSE117136.GATA4.pancreatic-progenitor 277 bp overlap

GATA6 11 datasets

ChIP DE DE-GATA6-1 769 bp overlap

ChIP DE DE-GATA6-2 788 bp overlap

ChIP DE_D1 S09-DE-d1-GATA6-exp1 588 bp overlap

ChIP DE_D1 S14-DE-d1-GATA6-exp1 635 bp overlap

ChIP DE_D1 S41-DE-d1-GATA6-exp2 679 bp overlap

ChIP DE_D2 S55-DE-d2-GATA6-exp2 605 bp overlap

ChIP HUES-8_DE_JNKi GSE109524.GATA6.HUES-8_DE_JNKi 739 bp overlap

ChIP HUES-8_DE_ctrl GSE109524.GATA6.HUES-8_DE_ctrl 782 bp overlap

ChIP PATU8988 GSE47535.GATA6.PATU8988 255 bp overlap

ChIP endoderm_KO GSE117136.GATA6.endoderm_KO 504 bp overlap

ChIP pancreatic-progenitor GSE117136.GATA6.pancreatic-progenitor 333 bp overlap

HAND2 3 datasets

ChIP CLB-Ga GSE90683.HAND2.CLB-Ga 585 bp overlap

ChIP Kelly GSE94822.HAND2.Kelly 266 bp overlap

ChIP SK-N-BE2-C GSE94822.HAND2.SK-N-BE2-C 524 bp overlap

HOXB13 1 dataset

ChIP G-401 GSE65381.HOXB13.G-401 338 bp overlap

Motif DE_36h DE_36h-Hmx2_MA0897.2 15 bp overlap

ChIP SK-N-BE2-C GSE94822.ISL1.SK-N-BE2-C 512 bp overlap

ISL2 2 datasets

Motif DE_36h DE_36h-ISL2_MA0914.2 6 bp overlap

Motif DE_60h DE_60h-ISL2_MA0914.2 6 bp overlap

ChIP DE_D1 S40-DE-d1-JUN-exp2 319 bp overlap

Motif DE_36h DE_36h-KLF1_MA0493.3 8 bp overlap

KLF10 1 dataset

Motif DE_36h DE_36h-KLF10_MA1511.2 9 bp overlap

KLF11 1 dataset

Motif DE_36h DE_36h-KLF11_MA1512.2 10 bp overlap

KLF14 1 dataset

Motif DE_36h DE_36h-KLF14_MA0740.2 9 bp overlap

KLF16 1 dataset

Motif DE_36h DE_36h-KLF16_MA0741.1 11 bp overlap

Motif DE_36h DE_36h-KLF2_MA1515.2 8 bp overlap

KLF4 2 datasets

ChIP BJ_INDUCED GSE36570.KLF4.BJ_INDUCED 220 bp overlap

Motif DE_36h DE_36h-KLF4_MA0039.5 8 bp overlap

Motif DE_36h DE_36h-KLF5_MA0599.1 10 bp overlap

Motif DE_36h DE_36h-KLF9_MA1107.3 11 bp overlap

LIN54 1 dataset

ChIP HepG2 ENCFF662XDE 177 bp overlap

MEF2D 2 datasets

ChIP retina_Hu13 GSE137311.MEF2D.retina_Hu13 191 bp overlap

ChIP retina_Hu25 GSE137311.MEF2D.retina_Hu25 214 bp overlap

Motif DE_36h DE_36h-MSC_MA0665.1 10 bp overlap

MYCN 4 datasets

ChIP COG-N-415 GSE138295.MYCN.COG-N-415 435 bp overlap

ChIP Kelly GSE94822.MYCN.Kelly 538 bp overlap

ChIP Kelly_sensitive GSE115249.MYCN.Kelly_sensitive 164 bp overlap

ChIP LA-N-5 GSE138295.MYCN.LA-N-5 495 bp overlap

NANOG 1 dataset

ChIP WA01_3IL ERP004238.NANOG.WA01_3IL 308 bp overlap

NEUROD1 5 datasets

ChIP D283-Med GSE92582.NEUROD1.D283-Med 438 bp overlap

ChIP D283-Med_shNEUROD1-1579 GSE92582.NEUROD1.D283-Med_shNEUROD1-1579 441 bp overlap

ChIP D341-Med_shGFP GSE92582.NEUROD1.D341-Med_shGFP 272 bp overlap

ChIP D341-Med_shNEUROD1-1154 GSE92582.NEUROD1.D341-Med_shNEUROD1-1154 174 bp overlap

ChIP D341-Med_shNEUROD1-1579 GSE92582.NEUROD1.D341-Med_shNEUROD1-1579 279 bp overlap

Nanog 1 dataset

Motif DE_36h DE_36h-Nanog_MA2339.1 7 bp overlap

Nkx3-2 2 datasets

Motif DE_36h DE_36h-Nkx3-2_MA0122.4 10 bp overlap

Motif DE_60h DE_60h-Nkx3-2_MA0122.4 10 bp overlap

ChIP retina_Hu7 GSE137311.OTX2.retina_Hu7 268 bp overlap

PATZ1 1 dataset

Motif DE_36h DE_36h-PATZ1_MA1961.2 11 bp overlap

Motif DE_36h DE_36h-PAX3_MA0780.1 10 bp overlap

PHOX2B 2 datasets

ChIP CLB-Ga GSE90683.PHOX2B.CLB-Ga 611 bp overlap

ChIP SK-N-BE2-C GSE94822.PHOX2B.SK-N-BE2-C 343 bp overlap

POU5F1 1 dataset

ChIP BJ_INDUCED GSE36570.POU5F1.BJ_INDUCED 186 bp overlap

PRDM1 1 dataset

ChIP fetal_testis GSE100639.PRDM1.fetal_testis 155 bp overlap

Motif DE_36h DE_36h-Pax7_MA0680.3 10 bp overlap

Motif DE_36h DE_36h-RARA_MA0730.1 17 bp overlap

RARA::RXRA 1 dataset

Motif DE_36h DE_36h-RARARXRA_MA0159.1 17 bp overlap

ChIP MCF-7_E2_45m GSE67295.RELA.MCF-7_E2_45m 104 bp overlap

ChIP retina_Hu22 GSE137311.RORB.retina_Hu22 270 bp overlap

Motif DE_36h DE_36h-Rarb_MA0858.1 17 bp overlap

Rhox11 2 datasets

Motif DE_36h DE_36h-Rhox11_MA0629.2 9 bp overlap

Motif DE_60h DE_60h-Rhox11_MA0629.2 9 bp overlap

Motif DE_36h DE_36h-SIX1_MA1118.2 9 bp overlap

Motif DE_36h DE_36h-SIX2_MA1119.2 11 bp overlap

SMAD2 1 dataset

ChIP endoderm GSE29422.SMAD2.endoderm 230 bp overlap

SMAD2-3 4 datasets

ChIP HGrC1_EV GSE138496.SMAD2-3.HGrC1_EV 117 bp overlap

ChIP HUES-8_DE GSE109524.SMAD2-3.HUES-8_DE 664 bp overlap

ChIP HUES-8_DE_JNKi GSE109524.SMAD2-3.HUES-8_DE_JNKi 511 bp overlap

ChIP HUES-8_DE_ctrl GSE109524.SMAD2-3.HUES-8_DE_ctrl 440 bp overlap

SMAD2_3 4 datasets

ChIP DE_D1 S12-DE-d1-SMAD2_3-exp1 483 bp overlap

ChIP DE_D1 S39-DE-d1-SMAD2_3-exp2 532 bp overlap

ChIP DE_D2 S01-DE-d2-SMAD2_3-exp1 558 bp overlap

ChIP DE_D2 S53-DE-d2-SMAD2_3-exp2 513 bp overlap

SMAD3 1 dataset

ChIP endoderm GSE29422.SMAD3.endoderm 239 bp overlap

SMAD4 1 dataset

ChIP endoderm GSE29422.SMAD4.endoderm 255 bp overlap

SMARCA4 1 dataset

ChIP NGP_ARID1A-mut2 GSE134626.SMARCA4.NGP_ARID1A-mut2 549 bp overlap

SMARCC1 1 dataset

ChIP DE_D1 S15-DE-d1-BAF155-exp1 420 bp overlap

SOX10 1 dataset

Motif DE_60h DE_60h-SOX10_MA0442.3 6 bp overlap

SOX11 1 dataset

ChIP GRANT-A519 GSE52146.SOX11.GRANT-A519 90 bp overlap

SOX17 1 dataset

ChIP DE_D2 DED2-SOX17_Batch_II 341 bp overlap

SOX17_M 1 dataset

ChIP DE_D2 DED2-SOX17-M_Batch_II 489 bp overlap

Motif DE_36h DE_36h-SP3_MA0746.3 11 bp overlap

Motif DE_36h DE_36h-SP8_MA0747.2 11 bp overlap

Motif DE_36h DE_36h-SP9_MA1564.2 10 bp overlap

Sox11 1 dataset

Motif DE_60h DE_60h-Sox11_MA0869.3 8 bp overlap

ChIP H9_ENDODERM GSE60606.T.H9_ENDODERM 321 bp overlap

TBX2 2 datasets

ChIP Kelly GSE94822.TBX2.Kelly 413 bp overlap

ChIP SK-N-BE2-C GSE94822.TBX2.SK-N-BE2-C 225 bp overlap

TEAD4 2 datasets

ChIP BE2C GSE84389.TEAD4.BE2C 422 bp overlap

ChIP SK-N-BE2 GSE84389.TEAD4.SK-N-BE2 422 bp overlap

TFAP2B 1 dataset

ChIP SK-N-SH ENCFF869XXQ 206 bp overlap

VENTX 1 dataset

Motif DE_36h DE_36h-VENTX_MA0724.1 9 bp overlap

ZBTB6 1 dataset

Motif DE_36h DE_36h-ZBTB6_MA1581.2 9 bp overlap

ZNF24 2 datasets

Motif DE_36h DE_36h-ZNF24_MA1124.1 13 bp overlap

Motif DE_60h DE_60h-ZNF24_MA1124.1 13 bp overlap

ZNF320 2 datasets

Motif DE_36h DE_36h-ZNF320_MA1976.2 20 bp overlap

ChIP HEK293 GSE76494.ZNF320.HEK293 157 bp overlap

ZNF354B 1 dataset

ChIP HepG2 ENCFF455UYM 81 bp overlap

ZNF454 1 dataset

Motif DE_36h DE_36h-ZNF454_MA1712.2 17 bp overlap

ZNF549 1 dataset

Motif DE_36h DE_36h-ZNF549_MA1728.2 8 bp overlap

ZNF667 2 datasets

Motif DE_36h DE_36h-ZNF667_MA1984.2 11 bp overlap

Motif DE_60h DE_60h-ZNF667_MA1984.2 11 bp overlap

ZNF740 1 dataset

Motif DE_36h DE_36h-ZNF740_MA0753.3 10 bp overlap