Members of the 'frizzled' gene family encode 7-transmembrane domain proteins that are receptors for Wnt signaling proteins. The FZD5 protein is believed to be the receptor for the Wnt5A ligand. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for FZD5. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = FZD5 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of FZD5, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr2:207,473,001–207,473,846 | 296.4 kb | Distal (>10kb) Multiome | 203 | |
| chr2:207,528,862–207,530,966 | 240.0 kb | Distal (>10kb) Multiome | 969 | |
| chr2:207,624,610–207,626,664 | 143.9 kb | Distal (>10kb) Multiome | 1079 | |
| chr2:207,681,149–207,682,035 | 88.3 kb | Distal (>10kb) Multiome | 73 | |
| chr2:207,710,626–207,712,680 | 58.4 kb | Distal (>10kb) Multiome | 950 | |
| chr2:207,756,775–207,760,396 | 9.5 kb | Proximal (<10kb) | 76 | |
| chr2:207,761,069–207,761,629 | 8.3 kb | Proximal (<10kb) | 58 | |
| chr2:207,761,948–207,762,391 | 7.5 kb | Proximal (<10kb) | 25 | |
| chr2:207,765,723–207,766,484 | 4.0 kb | Proximal (<10kb) Multiome | 343 | |
| chr2:207,766,763–207,771,365 | 41 bp | At TSS Multiome | 1084 | |
| chr2:207,772,300–207,772,738 | 2.4 kb | Proximal (<10kb) | 335 | |
| chr2:207,796,609–207,797,752 | 27.2 kb | Distal (>10kb) Multiome | 545 | |
| chr2:207,800,773–207,801,891 | 31.5 kb | Distal (>10kb) Multiome | 374 | |
| chr2:207,810,355–207,811,806 | 41.2 kb | Distal (>10kb) Multiome | 482 | |
| chr2:207,831,341–207,832,383 | 62.0 kb | Distal (>10kb) Multiome | 217 | |
| chr2:207,847,828–207,848,521 | 78.1 kb | Distal (>10kb) Multiome | 603 | |
| chr2:207,905,345–207,906,166 | 135.8 kb | Distal (>10kb) Multiome HiCAR | 83 | |
| chr2:207,970,009–207,971,155 | 200.6 kb | Distal (>10kb) Multiome HiCAR | 256 | |
| chr2:208,025,250–208,025,873 | 255.7 kb | Distal (>10kb) Multiome HiCAR | 1046 |
Genomic view of the FZD5 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.