Predicted to enable zinc ion binding activity. Predicted to be involved in myoblast differentiation. Predicted to be located in Golgi apparatus. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for PLEKHM3. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = PLEKHM3 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of PLEKHM3, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr2:207,624,610–207,626,664 | 399.5 kb | Distal (>10kb) Multiome HiCAR | 1079 | |
| chr2:207,765,723–207,766,484 | 259.6 kb | Distal (>10kb) Multiome HiCAR | 343 | |
| chr2:207,766,763–207,771,365 | 255.6 kb | Distal (>10kb) Multiome HiCAR | 1084 | |
| chr2:207,796,609–207,797,752 | 228.5 kb | Distal (>10kb) Multiome HiCAR | 545 | |
| chr2:207,800,773–207,801,891 | 224.1 kb | Distal (>10kb) Multiome | 374 | |
| chr2:207,810,355–207,811,806 | 214.4 kb | Distal (>10kb) Multiome | 482 | |
| chr2:207,831,341–207,832,383 | 193.6 kb | Distal (>10kb) Multiome HiCAR | 217 | |
| chr2:207,847,828–207,848,521 | 177.5 kb | Distal (>10kb) Multiome | 603 | |
| chr2:207,905,345–207,906,166 | 119.8 kb | Distal (>10kb) Multiome | 83 | |
| chr2:207,970,009–207,971,155 | 55.0 kb | Distal (>10kb) Multiome | 256 | |
| chr2:208,025,250–208,025,873 | 35 bp | At TSS Multiome | 1046 | |
| chr2:208,030,729–208,031,218 | 5.2 kb | Proximal (<10kb) | 20 | |
| chr2:208,034,127–208,034,405 | 8.6 kb | Proximal (<10kb) | 366 | |
| chr2:208,112,378–208,113,769 | 87.7 kb | Distal (>10kb) Multiome | 285 | |
| chr2:208,124,049–208,124,760 | 98.9 kb | Distal (>10kb) Multiome | 140 | |
| chr2:208,142,720–208,143,849 | 117.8 kb | Distal (>10kb) Multiome | 333 | |
| chr2:208,215,744–208,216,551 | 190.6 kb | Distal (>10kb) Multiome | 25 | |
| chr2:208,253,738–208,255,989 | 228.7 kb | Distal (>10kb) Multiome | 1085 | |
| chr2:208,265,281–208,266,835 | 240.7 kb | Distal (>10kb) Multiome | 1005 | |
| chr2:208,267,505–208,268,088 | 242.3 kb | Distal (>10kb) Multiome | 169 | |
| chr2:208,317,884–208,318,936 | 292.8 kb | Distal (>10kb) Multiome | 106 |
Genomic view of the PLEKHM3 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.