chr16 : 22,903,532 – 22,904,183

651 bp 68 TFs 3 linked genes

This 651 bp open chromatin element is linked to HS3ST2, USP31, and ENSG00000291073 and is bound by 68 transcription factors.

Linked Genes

3 genes

Gene	Dist. to TSS	Distance	Link type
HS3ST2	89.8 kb	Distal	Multiome
USP31	245.5 kb	Distal	Multiome
ENSG00000291073	1401.7 kb	Distal	Multiome+HiCAR

Chromatin Accessibility

Genome Browser

Genomic view centred on this element. Tracks include ATAC-seq accessibility, RNA-seq expression, TF binding peaks, and element-to-gene loop arcs across the ESC → DE time course.

Transcription factors with ChIP-seq peak overlap or TOBIAS motif footprint evidence at this element.

TF Binding

68 transcription factors

BRD4 1 dataset

ChIP HEK293_sgNT GSE129407.BRD4.HEK293_sgNT 277 bp overlap

Bcl11B 1 dataset

Motif DE_72h DE_72h-Bcl11B_MA1989.2 9 bp overlap

CASZ1 1 dataset

ChIP rhabdomyosarcoma_Trametinib GSE126143.CASZ1.rhabdomyosarcoma_Trametinib 314 bp overlap

Cebpa 1 dataset

ChIP BLaER1 ENCFF896HSY 245 bp overlap

Crx 1 dataset

Motif DE_72h DE_72h-Crx_MA0467.3 6 bp overlap

DUX4 2 datasets

Motif DE_72h DE_72h-DUX4_MA0468.1 11 bp overlap

ChIP WA01 GSE94322.DUX4.WA01 185 bp overlap

Dux 1 dataset

Motif DE_72h DE_72h-Dux_MA0611.3 11 bp overlap

EOMES 1 dataset

ChIP hESC GSE26097.EOMES.hESC 483 bp overlap

ESR1 1 dataset

ChIP MCF-7_LTED GSE86538.ESR1.MCF-7_LTED 110 bp overlap

EZH2 5 datasets

ChIP A-1847_CARM1-KO GSE95643.EZH2.A-1847_CARM1-KO 577 bp overlap

ChIP DND-41 ENCFF187XWF 205 bp overlap

ChIP DND-41 ENCFF187XWF 445 bp overlap

ChIP DND41 ENCSR000ASW.EZH2.DND41 280 bp overlap

ChIP HCT-116 ENCSR046HGP.EZH2.HCT-116 168 bp overlap

FOXA2 3 datasets

ChIP DE DE-FOXA2-1 651 bp overlap

ChIP DE DE-FOXA2-2 651 bp overlap

Motif DE_72h DE_72h-FOXA2_MA0047.4 8 bp overlap

FOXA3 1 dataset

Motif DE_72h DE_72h-FOXA3_MA1683.2 7 bp overlap

FOXI1 1 dataset

Motif DE_72h DE_72h-FOXI1_MA0042.2 7 bp overlap

FOXP1 1 dataset

Motif DE_72h DE_72h-FOXP1_MA0481.4 7 bp overlap

FOXP4 1 dataset

Motif DE_72h DE_72h-FOXP4_MA2117.1 7 bp overlap

FOXS1 1 dataset

Motif DE_72h DE_72h-FOXS1_MA2118.1 8 bp overlap

GATA4 5 datasets

ChIP DE DE-GATA4-1 651 bp overlap

ChIP DE DE-GATA4-2 651 bp overlap

ChIP foregut GSE117136.GATA4.foregut 651 bp overlap

ChIP pancreatic-progenitor GSE117136.GATA4.pancreatic-progenitor 571 bp overlap

ChIP pancreatic-progenitor_PP1 GSE104840.GATA4.pancreatic-progenitor_PP1 234 bp overlap

GATA6 11 datasets

ChIP DE DE-GATA6-1 651 bp overlap

ChIP DE DE-GATA6-2 651 bp overlap

ChIP DE_D1 S09-DE-d1-GATA6-exp1 651 bp overlap

ChIP DE_D1 S14-DE-d1-GATA6-exp1 647 bp overlap

ChIP DE_D1 S41-DE-d1-GATA6-exp2 528 bp overlap

ChIP DE_D2 S55-DE-d2-GATA6-exp2 651 bp overlap

ChIP HUES-8_DE_JNKi GSE109524.GATA6.HUES-8_DE_JNKi 651 bp overlap

ChIP HUES-8_DE_ctrl GSE109524.GATA6.HUES-8_DE_ctrl 638 bp overlap

ChIP endoderm_KO GSE117136.GATA6.endoderm_KO 651 bp overlap

ChIP foregut GSE117136.GATA6.foregut 651 bp overlap

ChIP pancreatic-progenitor GSE117136.GATA6.pancreatic-progenitor 612 bp overlap

GSC 1 dataset

Motif DE_72h DE_72h-GSC_MA0648.2 6 bp overlap

GSC2 1 dataset

Motif DE_72h DE_72h-GSC2_MA0891.2 6 bp overlap

HOXD12::ELK1 1 dataset

Motif DE_72h DE_72h-HOXD12ELK1_MA1958.2 13 bp overlap

JUN 2 datasets

ChIP DE_D1 S13-DE-d1-JUN-exp1 264 bp overlap

ChIP DE_D2 S02-DE-d2-JUN-exp1 254 bp overlap

MAFG 1 dataset

ChIP HepG2 ENCFF422NZT 168 bp overlap

MEF2A 1 dataset

Motif DE_72h DE_72h-MEF2A_MA0052.5 10 bp overlap

MEF2B 1 dataset

Motif DE_72h DE_72h-MEF2B_MA0660.1 12 bp overlap

MEF2C 1 dataset

Motif DE_72h DE_72h-MEF2C_MA0497.2 11 bp overlap

MEF2D 1 dataset

Motif DE_72h DE_72h-MEF2D_MA0773.1 12 bp overlap

MEIS1 2 datasets

Motif DE_72h DE_72h-MEIS1_MA0498.3 5 bp overlap

MXI1 1 dataset

Motif DE_72h DE_72h-MXI1_MA1108.3 6 bp overlap

MYB 1 dataset

Motif DE_72h DE_72h-MYB_MA0100.4 6 bp overlap

NFYA 1 dataset

Motif DE_72h DE_72h-NFYA_MA0060.4 8 bp overlap

NFYC 1 dataset

Motif DE_72h DE_72h-NFYC_MA1644.2 7 bp overlap

OTX1 1 dataset

Motif DE_72h DE_72h-OTX1_MA0711.2 6 bp overlap

OTX2 1 dataset

Motif DE_72h DE_72h-OTX2_MA0712.3 7 bp overlap

PBX2 1 dataset

Motif DE_72h DE_72h-PBX2_MA1113.3 9 bp overlap

PHOX2A 1 dataset

Motif DE_72h DE_72h-PHOX2A_MA0713.1 11 bp overlap

PITX1 1 dataset

Motif DE_72h DE_72h-PITX1_MA0682.3 6 bp overlap

PITX2 1 dataset

Motif DE_72h DE_72h-PITX2_MA1547.2 8 bp overlap

PITX3 1 dataset

Motif DE_72h DE_72h-PITX3_MA0714.2 6 bp overlap

PPARG 2 datasets

Motif DE_72h DE_72h-PPARG_MA0066.2 19 bp overlap

Pparg::Rxra 1 dataset

Motif DE_72h DE_72h-PpargRxra_MA0065.3 13 bp overlap

RHOXF1 1 dataset

Motif DE_72h DE_72h-RHOXF1_MA0719.2 6 bp overlap

RUNX2 1 dataset

Motif DE_72h DE_72h-RUNX2_MA0511.2 9 bp overlap

Runx1 1 dataset

Motif DE_72h DE_72h-Runx1_MA0002.3 9 bp overlap

SMAD2 1 dataset

ChIP endoderm GSE29422.SMAD2.endoderm 395 bp overlap

SMAD2-3 3 datasets

ChIP HUES-8_DE GSE109524.SMAD2-3.HUES-8_DE 651 bp overlap

ChIP HUES-8_DE_JNKi GSE109524.SMAD2-3.HUES-8_DE_JNKi 644 bp overlap

ChIP HUES-8_DE_ctrl GSE109524.SMAD2-3.HUES-8_DE_ctrl 494 bp overlap

SMAD2_3 5 datasets

ChIP DE_D1 S07-DE-d1-SMAD2_3-exp1 418 bp overlap

ChIP DE_D1 S12-DE-d1-SMAD2_3-exp1 611 bp overlap

ChIP DE_D1 S39-DE-d1-SMAD2_3-exp2 304 bp overlap

ChIP DE_D2 S01-DE-d2-SMAD2_3-exp1 651 bp overlap

ChIP DE_D2 S53-DE-d2-SMAD2_3-exp2 651 bp overlap

SMAD3 1 dataset

ChIP endoderm GSE29422.SMAD3.endoderm 508 bp overlap

SMAD4 1 dataset

ChIP endoderm GSE29422.SMAD4.endoderm 367 bp overlap

SMARCC1 1 dataset

ChIP hiPSC GSE124903.SMARCC1.hiPSC 157 bp overlap

SOX15 1 dataset

Motif DE_72h DE_72h-SOX15_MA1152.2 7 bp overlap

SOX17 1 dataset

ChIP DE_D2 DED2-SOX17_Batch_II 469 bp overlap

SOX17_M 1 dataset

ChIP DE_D2 DED2-SOX17-M_Batch_II 637 bp overlap

Sox1 1 dataset

Motif DE_72h DE_72h-Sox1_MA0870.1 15 bp overlap

T 1 dataset

ChIP H9_ENDODERM GSE60606.T.H9_ENDODERM 396 bp overlap

Tbx6 1 dataset

Motif DE_72h DE_72h-Tbx6_MA1567.3 9 bp overlap

ZBTB18 1 dataset

Motif DE_72h DE_72h-ZBTB18_MA0698.2 11 bp overlap

ZIC1 1 dataset

Motif DE_72h DE_72h-ZIC1_MA0696.1 14 bp overlap

ZIC4 1 dataset

Motif DE_72h DE_72h-ZIC4_MA0751.2 14 bp overlap

ZNF157 1 dataset

Motif DE_72h DE_72h-ZNF157_MA2331.1 21 bp overlap

ZNF184 1 dataset

Motif DE_72h DE_72h-ZNF184_MA2120.1 13 bp overlap

ZNF214 1 dataset

Motif DE_72h DE_72h-ZNF214_MA1975.2 13 bp overlap

ZNF354C 1 dataset

Motif DE_72h DE_72h-ZNF354C_MA0130.1 6 bp overlap

ZNF454 1 dataset

Motif DE_72h DE_72h-ZNF454_MA1712.2 17 bp overlap

ZNF530 1 dataset

Motif DE_72h DE_72h-ZNF530_MA1981.2 14 bp overlap

ZNF549 1 dataset

Motif DE_72h DE_72h-ZNF549_MA1728.2 8 bp overlap

ZNF85 1 dataset

Motif DE_72h DE_72h-ZNF85_MA1720.2 12 bp overlap

Zfx 1 dataset

Motif DE_72h DE_72h-Zfx_MA0146.3 10 bp overlap