Heparan sulfate biosynthetic enzymes are key components in generating a myriad of distinct heparan sulfate fine structures that carry out multiple biologic activities. The enzyme encoded by this gene is a member of the heparan sulfate biosynthetic enzyme family. It is a type II integral membrane protein and possesses heparan sulfate glucosaminyl 3-O-sulfotransferase activity. This gene is expressed predominantly in brain and may play a role in the nervous system. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for HS3ST2. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = HS3ST2 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of HS3ST2, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr16:21,501,368–21,502,964 | 1311.8 kb | Distal (>10kb) Multiome HiCAR | 766 | |
| chr16:21,519,749–21,521,002 | 1293.7 kb | Distal (>10kb) Multiome HiCAR | 859 | |
| chr16:21,521,389–21,522,043 | 1292.4 kb | Distal (>10kb) Multiome HiCAR | 479 | |
| chr16:22,634,974–22,635,717 | 178.8 kb | Distal (>10kb) Multiome | 127 | |
| chr16:22,727,898–22,728,946 | 85.8 kb | Distal (>10kb) Multiome | 321 | |
| chr16:22,813,233–22,813,685 | 786 bp | At TSS Multiome | 547 | |
| chr16:22,813,795–22,814,968 | 79 bp | At TSS Multiome | 204 | |
| chr16:22,903,532–22,904,183 | 89.8 kb | Distal (>10kb) Multiome | 68 |
Genomic view of the HS3ST2 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.