CASZ1

castor zinc finger 1 | FLJ20321, SRG, ZNF693, castor, cst

The protein encoded by this gene is a zinc finger transcription factor. The encoded protein may function as a tumor suppressor, and single nucleotide polymorphisms in this gene are associated with blood pressure variation. Alternative splicing results in multiple transcript variants that encode different protein isoforms. [provided by RefSeq, Jul 2012]

Biological processes 13 terms

DNA-binding transcription activator activity, RNA polymerase II-specific (GO:0001228)DNA-binding transcription factor activity, RNA polymerase II-specific (GO:0000981)RNA polymerase II transcription regulatory region sequence-specific DNA binding (GO:0000977)RNA polymerase II transcription regulatory region sequence-specific DNA binding (GO:0000977)chromatin (GO:0000785)nucleoplasm (GO:0005654)nucleus (GO:0005634)nucleus (GO:0005634)positive regulation of DNA-templated transcription (GO:0045893)positive regulation of transcription by RNA polymerase II (GO:0045944)positive regulation of transcription by RNA polymerase II (GO:0045944)regulation of DNA-templated transcription (GO:0006355)regulation of neuron differentiation (GO:0045664)

Expression (TPM)

TFs regulating CASZ1 0 TFs

Transcription factors with Perturb-seq knockdown data for CASZ1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = CASZ1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.

TF	Mean coef	Binding	Outlier	TF→Gene link

Rows:

Elements linked to CASZ1

Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of CASZ1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.

Element	Dist. to TSS	Link type	TFs
chr1:10,638,357–10,639,497	157.5 kb	Distal (>10kb) Multiome	126
chr1:10,679,481–10,679,929	116.8 kb	Distal (>10kb) Multiome	463
chr1:10,693,857–10,695,287	101.9 kb	Distal (>10kb) Multiome	382
chr1:10,704,382–10,704,894	92.0 kb	Distal (>10kb) Multiome	393
chr1:10,793,659–10,795,336	2.7 kb	Proximal (<10kb) Multiome	450
chr1:10,796,172–10,796,997	30 bp	At TSS Multiome	574
chr1:10,835,650–10,836,437	39.4 kb	Distal (>10kb) Multiome	422
chr1:10,866,886–10,867,599	70.6 kb	Distal (>10kb) Multiome	364
chr1:11,011,823–11,013,364	215.8 kb	Distal (>10kb) Multiome	974
chr1:11,052,805–11,053,698	256.7 kb	Distal (>10kb) Multiome	314
chr1:11,059,469–11,060,508	263.5 kb	Distal (>10kb) Multiome	659

Genome Browser

Genomic view of the CASZ1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.