Transcription factors with Perturb-seq knockdown data for ENSG00000291073. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ENSG00000291073 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ENSG00000291073, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr16:21,277,829–21,278,645 | 224.0 kb | Distal (>10kb) Multiome | 636 | |
| chr16:21,283,543–21,284,106 | 218.4 kb | Distal (>10kb) Multiome | 488 | |
| chr16:21,300,604–21,301,993 | 201.5 kb | Distal (>10kb) Multiome | 1062 | |
| chr16:21,302,514–21,303,208 | 199.4 kb | Distal (>10kb) Multiome | 136 | |
| chr16:21,501,368–21,502,964 | 64 bp | At TSS Multiome | 766 | |
| chr16:21,519,749–21,521,002 | 18.2 kb | Distal (>10kb) Multiome | 859 | |
| chr16:21,521,389–21,522,043 | 19.5 kb | Distal (>10kb) Multiome | 479 | |
| chr16:21,598,942–21,600,295 | 97.3 kb | Distal (>10kb) Multiome | 1085 | |
| chr16:22,436,881–22,437,622 | 934.8 kb | Distal (>10kb) Multiome HiCAR | 642 | |
| chr16:22,634,974–22,635,717 | 1133.1 kb | Distal (>10kb) Multiome HiCAR | 127 | |
| chr16:22,813,233–22,813,685 | 1311.1 kb | Distal (>10kb) Multiome HiCAR | 547 | |
| chr16:22,813,795–22,814,968 | 1312.0 kb | Distal (>10kb) Multiome HiCAR | 204 | |
| chr16:22,903,532–22,904,183 | 1401.7 kb | Distal (>10kb) Multiome HiCAR | 68 | |
| chr16:23,182,254–23,183,374 | 1680.4 kb | Distal (>10kb) Multiome HiCAR | 606 |
Genomic view of the ENSG00000291073 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.