chr12 : 106,128,962 – 106,129,446

484 bp 60 TFs 1 linked gene

This 484 bp open chromatin element is linked to NUAK1 and is bound by 60 transcription factors.

Linked Genes

1 gene

Gene	Expression	Dist. to TSS	Distance	Link type
NUAK1		9.5 kb	Proximal	Proximity

Chromatin Accessibility

Genome Browser

Genomic view centred on this element. Tracks include ATAC-seq accessibility, RNA-seq expression, TF binding peaks, and element-to-gene loop arcs across the ESC → DE time course.

Transcription factors with ChIP-seq peak overlap or TOBIAS motif footprint evidence at this element.

TF Binding

60 transcription factors

ARID2 3 datasets

ChIP BIN-67_lentivirus-SMARCA4 GSE117734.ARID2.BIN-67_lentivirus-SMARCA4 304 bp overlap

ChIP BIN-67_lentivirus-SMARCA4-K785R GSE117734.ARID2.BIN-67_lentivirus-SMARCA4-K785R 484 bp overlap

ChIP BIN-67_lentivirus-SMARCA4-T910M GSE117734.ARID2.BIN-67_lentivirus-SMARCA4-T910M 249 bp overlap

ARNT 1 dataset

ChIP MCF-7_aza GSE85352.ARNT.MCF-7_aza 376 bp overlap

ASCL1 5 datasets

ChIP NCI-H128 GSE69394.ASCL1.NCI-H128 152 bp overlap

ChIP NCI-H2107 GSE69394.ASCL1.NCI-H2107 147 bp overlap

ChIP NCI-H889 GSE69394.ASCL1.NCI-H889 159 bp overlap

ChIP SCLC_ASCLP GSE61197.ASCL1.SCLC_ASCLP 259 bp overlap

ChIP SCLC_ASCLP_NE GSE61197.ASCL1.SCLC_ASCLP_NE 149 bp overlap

Atoh1 1 dataset

Motif DE_24h DE_24h-Atoh1_MA1467.3 7 bp overlap

BCOR 1 dataset

ChIP WA01_RNF2-R GSE104690.BCOR.WA01_RNF2-R 216 bp overlap

BHLHE22 1 dataset

ChIP CAL-1 GSE43876.BHLHE22.CAL-1 160 bp overlap

BRD4 1 dataset

ChIP NCI-H1963_shNONT GSE145028.BRD4.NCI-H1963_shNONT 472 bp overlap

CBX2 1 dataset

ChIP HEK293T GSE34774.CBX2.HEK293T 414 bp overlap

E2F6 1 dataset

ChIP WA01 ENCSR000BSI.E2F6.WA01 246 bp overlap

ESR1 1 dataset

ChIP T-47D_DMSO GSE148277.ESR1.T-47D_DMSO 233 bp overlap

EZH2 1 dataset

ChIP DND41 ENCSR000ASW.EZH2.DND41 239 bp overlap

FEZF1 1 dataset

ChIP HEK293 ENCSR827NWO.FEZF1.HEK293 78 bp overlap

GATA4 1 dataset

ChIP DE DE-GATA4-2 197 bp overlap

GATA6 8 datasets

ChIP DE DE-GATA6-2 229 bp overlap

ChIP DE_D1 S09-DE-d1-GATA6-exp1 71 bp overlap

ChIP DE_D1 S14-DE-d1-GATA6-exp1 108 bp overlap

ChIP DE_D1 S41-DE-d1-GATA6-exp2 142 bp overlap

ChIP DE_D2 S55-DE-d2-GATA6-exp2 300 bp overlap

ChIP HUES-8_DE_JNKi GSE109524.GATA6.HUES-8_DE_JNKi 149 bp overlap

ChIP HUES-8_DE_ctrl GSE109524.GATA6.HUES-8_DE_ctrl 121 bp overlap

ChIP endoderm_KO GSE117136.GATA6.endoderm_KO 101 bp overlap

HAND2 1 dataset

Motif DE_24h DE_24h-HAND2_MA1638.2 6 bp overlap

HNF4A 2 datasets

Motif DE_24h DE_24h-HNF4A_MA0114.5 9 bp overlap

ChIP Hep-G2 ENCSR469FBY.HNF4A.Hep-G2 148 bp overlap

HNF4G 1 dataset

Motif DE_24h DE_24h-HNF4G_MA0484.3 9 bp overlap

HOXB13 1 dataset

ChIP G-401 GSE65381.HOXB13.G-401 430 bp overlap

JUN 2 datasets

ChIP DE_D1 S40-DE-d1-JUN-exp2 66 bp overlap

ChIP MDA-BoM-1833 GSE112444.JUN.MDA-BoM-1833 201 bp overlap

MAF 2 datasets

Motif DE_12h DE_12h-MAF_MA1520.2 13 bp overlap

Motif DE_24h DE_24h-MAF_MA1520.2 13 bp overlap

MAFA 2 datasets

Motif DE_12h DE_12h-MAFA_MA1521.2 13 bp overlap

Motif DE_24h DE_24h-MAFA_MA1521.2 13 bp overlap

MAX 2 datasets

ChIP NCI-H2171 GSE41105.MAX.NCI-H2171 233 bp overlap

ChIP NCI-H2171 GSE36354.MAX.NCI-H2171 195 bp overlap

MTF2 1 dataset

ChIP DU145_SH4 GSE135623.MTF2.DU145_SH4 280 bp overlap

MYC 1 dataset

ChIP NCI-H2171 GSE36354.MYC.NCI-H2171 263 bp overlap

MYCN 1 dataset

ChIP RH4 GSE83726.MYCN.RH4 295 bp overlap

NCAPH2 1 dataset

ChIP RMG-I GSE120058.NCAPH2.RMG-I 131 bp overlap

NEUROG2 1 dataset

Motif DE_24h DE_24h-NEUROG2_MA1642.2 7 bp overlap

NKX2-1 1 dataset

ChIP NCI-H1819 GSE39998.NKX2-1.NCI-H1819 349 bp overlap

PAX3-FOXO1 1 dataset

ChIP RH4 GSE140115.PAX3-FOXO1.RH4 174 bp overlap

PHIP 1 dataset

ChIP HEK293_ab833 GSE101646.PHIP.HEK293_ab833 346 bp overlap

POU2F3 2 datasets

Motif DE_12h DE_12h-POU2F3_MA0627.3 9 bp overlap

Motif DE_24h DE_24h-POU2F3_MA0627.3 9 bp overlap

POU5F1 5 datasets

ChIP BG03 GSE21614.POU5F1.BG03 257 bp overlap

Motif DE_12h DE_12h-POU5F1_MA1115.2 7 bp overlap

Motif DE_24h DE_24h-POU5F1_MA1115.2 7 bp overlap

ChIP DE_D1 DED1-OCT4_Batch_II 429 bp overlap

ChIP HUES-8 GSE109524.POU5F1.HUES-8 288 bp overlap

POU5F1_M 1 dataset

ChIP DE_D1 DED1-OCT4-M_Batch_II 358 bp overlap

PRDM10 1 dataset

ChIP HEK293 ENCFF145WQQ 131 bp overlap

PRDM14 1 dataset

ChIP NCCIT GSE71675.PRDM14.NCCIT 288 bp overlap

PRDM6 2 datasets

ChIP HEK293 ENCFF283AJL 52 bp overlap

ChIP HEK293 ENCSR892QHR.PRDM6.HEK293 75 bp overlap

Prdm5 1 dataset

Motif DE_24h DE_24h-Prdm5_MA1999.2 11 bp overlap

RAD21 1 dataset

ChIP RH4 GSE83726.RAD21.RH4 280 bp overlap

SMAD2-3 1 dataset

ChIP HUES-8_DE GSE109524.SMAD2-3.HUES-8_DE 366 bp overlap

SMAD2_3 1 dataset

ChIP DE_D2 S01-DE-d2-SMAD2_3-exp1 192 bp overlap

SMARCA4 1 dataset

ChIP BIN-67_lentivirus-SMARCA4-K785R GSE117734.SMARCA4.BIN-67_lentivirus-SMARCA4-K785R 484 bp overlap

SMARCC1 2 datasets

ChIP BIN-67_lentivirus-SMARCA4-T910M GSE117734.SMARCC1.BIN-67_lentivirus-SMARCA4-T910M 194 bp overlap

ChIP hiPSC_WT GSE124903.SMARCC1.hiPSC_WT 208 bp overlap

SOX17 1 dataset

ChIP DE_D2 DED2-SOX17_Batch_II 339 bp overlap

SOX17_M 1 dataset

ChIP DE_D2 DED2-SOX17-M_Batch_II 406 bp overlap

TCF12 1 dataset

ChIP WA01 ENCSR000BIT.TCF12.WA01 131 bp overlap

TFAP2A 1 dataset

Motif DE_12h DE_12h-TFAP2A_MA0003.5 9 bp overlap

TFAP2C 3 datasets

Motif DE_12h DE_12h-TFAP2C_MA0814.3 9 bp overlap

ChIP UCLA1-hESCs_TFAP2C--_1d_TFAP2C_Induc GSE101074.TFAP2C.UCLA1-hESCs_TFAP2C--_1d_TFAP2C_Induc 484 bp overlap

ChIP UCLA1-hESCs_TFAP2C--_2d_TFAP2C_Induc GSE101074.TFAP2C.UCLA1-hESCs_TFAP2C--_2d_TFAP2C_Induc 437 bp overlap

ZBTB44 2 datasets

ChIP HEK293 ENCFF560VPN 143 bp overlap

ChIP HEK293 ENCSR076STQ.ZBTB44.HEK293 103 bp overlap

ZFP14 1 dataset

Motif DE_12h DE_12h-ZFP14_MA1972.1 15 bp overlap

ZFY 1 dataset

ChIP Hep-G2 ENCSR949OEV.ZFY.Hep-G2 163 bp overlap

ZNF24 2 datasets

ChIP K-562 ENCSR695EQB.ZNF24.K-562 246 bp overlap

ChIP K-562 ENCSR117WTM.ZNF24.K-562 152 bp overlap

ZNF331 1 dataset

Motif DE_12h DE_12h-ZNF331_MA1726.2 10 bp overlap

ZNF416 1 dataset

Motif DE_24h DE_24h-ZNF416_MA1979.2 10 bp overlap

ZNF561 1 dataset

ChIP HEK293 ENCSR125ULS.ZNF561.HEK293 71 bp overlap

ZNF667 1 dataset

Motif DE_12h DE_12h-ZNF667_MA1984.2 11 bp overlap

ZNF684 1 dataset

Motif DE_24h DE_24h-ZNF684_MA1600.2 14 bp overlap

ZNF687 1 dataset

ChIP HepG2 ENCFF653WIX 484 bp overlap

ZNF701 1 dataset

Motif DE_12h DE_12h-ZNF701_MA1987.2 17 bp overlap

ZNF770 3 datasets

Motif DE_12h DE_12h-ZNF770_MA2099.1 8 bp overlap

ChIP HEK293 ENCSR242BGR.ZNF770.HEK293 351 bp overlap

ChIP HEK293 GSE76494.ZNF770.HEK293 219 bp overlap

ZSCAN4 2 datasets

Motif DE_12h DE_12h-ZSCAN4_MA1155.1 15 bp overlap

Motif DE_24h DE_24h-ZSCAN4_MA1155.1 15 bp overlap