Enables p53 binding activity and protein serine/threonine kinase activity. Involved in protein phosphorylation; regulation of cell adhesion; and regulation of cellular senescence. Located in cytoplasm; microtubule cytoskeleton; and nuclear lumen. Implicated in uterine fibroid. Biomarker of uterine fibroid. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for NUAK1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = NUAK1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of NUAK1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr12:105,459,868–105,460,332 | 678.9 kb | Distal (>10kb) Multiome HiCAR | 58 | |
| chr12:105,716,264–105,717,250 | 422.2 kb | Distal (>10kb) Multiome HiCAR | 52 | |
| chr12:105,736,532–105,737,375 | 402.1 kb | Distal (>10kb) Multiome HiCAR | 134 | |
| chr12:105,847,918–105,848,868 | 290.5 kb | Distal (>10kb) Multiome HiCAR | 144 | |
| chr12:105,897,110–105,897,797 | 241.4 kb | Distal (>10kb) Multiome | 140 | |
| chr12:105,986,583–105,987,623 | 151.9 kb | Distal (>10kb) Multiome | 272 | |
| chr12:106,128,962–106,129,446 | 9.5 kb | Proximal (<10kb) | 60 | |
| chr12:106,132,281–106,132,921 | 6.0 kb | Proximal (<10kb) | 64 | |
| chr12:106,136,051–106,136,725 | 2.2 kb | Proximal (<10kb) | 256 | |
| chr12:106,138,295–106,140,144 | 158 bp | At TSS Multiome | 675 | |
| chr12:106,247,023–106,248,967 | 109.2 kb | Distal (>10kb) Multiome | 593 | |
| chr12:106,301,702–106,303,676 | 164.6 kb | Distal (>10kb) Multiome | 881 | |
| chr12:106,357,226–106,358,686 | 219.0 kb | Distal (>10kb) Multiome | 1122 |
Genomic view of the NUAK1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.