Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for ZNF561. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ZNF561 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ZNF561, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr19:9,323,540–9,324,623 | 297.0 kb | Distal (>10kb) Multiome | 577 | |
| chr19:9,435,095–9,435,909 | 185.6 kb | Distal (>10kb) Multiome | 701 | |
| chr19:9,538,339–9,539,009 | 82.5 kb | Distal (>10kb) Multiome | 759 | |
| chr19:9,582,064–9,582,785 | 38.7 kb | Distal (>10kb) Multiome | 99 | |
| chr19:9,584,055–9,584,863 | 36.6 kb | Distal (>10kb) Multiome | 801 | |
| chr19:9,620,792–9,622,027 | 145 bp | At TSS Multiome | 856 | |
| chr19:9,674,791–9,675,456 | 53.9 kb | Distal (>10kb) Multiome | 793 | |
| chr19:9,768,230–9,769,267 | 147.5 kb | Distal (>10kb) Multiome | 893 | |
| chr19:9,784,209–9,786,632 | 164.6 kb | Distal (>10kb) Multiome HiCAR | 727 | |
| chr19:9,791,515–9,793,483 | 171.6 kb | Distal (>10kb) Multiome HiCAR | 507 | |
| chr19:9,818,302–9,820,113 | 198.2 kb | Distal (>10kb) Multiome HiCAR | 870 | |
| chr19:9,827,304–9,828,194 | 206.6 kb | Distal (>10kb) Multiome | 742 | |
| chr19:9,834,598–9,835,806 | 213.9 kb | Distal (>10kb) Multiome | 681 | |
| chr19:9,913,549–9,914,444 | 292.5 kb | Distal (>10kb) Multiome | 322 | |
| chr19:9,914,501–9,914,999 | 293.7 kb | Distal (>10kb) Multiome | 587 |
Genomic view of the ZNF561 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.