chr12:1,580,606–1,581,311

chr12 : 1,580,606 – 1,581,311

705 bp 62 TFs 6 linked genes

This 705 bp open chromatin element is linked to 6 target genes and is bound by 62 transcription factors.

Linked Genes

6 genes

Gene	Expression	Dist. to TSS	Distance	Link type
FBXL14		13.7 kb	Distal	Multiome
WNT5B		50.9 kb	Distal	Multiome
ADIPOR2		110.2 kb	Distal	Multiome
ERC1		589.6 kb	Distal	Multiome+HiCAR
RAD52		631.2 kb	Distal	Multiome+HiCAR
WNK1		828.2 kb	Distal	Multiome+HiCAR

Chromatin Accessibility

Genome Browser

Genomic view centred on this element. Tracks include ATAC-seq accessibility, RNA-seq expression, TF binding peaks, and element-to-gene loop arcs across the ESC → DE time course.

Transcription factors with ChIP-seq peak overlap or TOBIAS motif footprint evidence at this element.

TF Binding

62 transcription factors

ASCL1 1 dataset

ChIP NCI-H82 GSE69394.ASCL1.NCI-H82 188 bp overlap

BRD4 2 datasets

ChIP retina_AB1-FW15 GSE86981.BRD4.retina_AB1-FW15 211 bp overlap

ChIP retina_AB1-FW23 GSE86981.BRD4.retina_AB1-FW23 286 bp overlap

CBFA2T2 1 dataset

ChIP NCCIT GSE71675.CBFA2T2.NCCIT 105 bp overlap

ChIP hiPSC_derived_lt-NES GSE108506.CHD7.hiPSC_derived_lt-NES 202 bp overlap

ChIP retina_Hu20 GSE137311.CRX.retina_Hu20 249 bp overlap

ChIP retina_Hu3 GSE137311.CRX.retina_Hu3 381 bp overlap

ChIP retina_Hu6 GSE137311.CRX.retina_Hu6 373 bp overlap

CTCF 2 datasets

ChIP retina_Hu22 GSE137311.CTCF.retina_Hu22 226 bp overlap

ChIP retina_Hu25 GSE137311.CTCF.retina_Hu25 276 bp overlap

Cebpa 5 datasets

ChIP BLaER1 ENCFF262VBH 349 bp overlap

ChIP BLaER1 ENCFF274GAT 547 bp overlap

ChIP BLaER1 ENCFF335XTP 359 bp overlap

ChIP BLaER1 ENCFF460KDD 276 bp overlap

ChIP BLaER1 ENCFF460KDD 109 bp overlap

E2F6 2 datasets

Motif DE_48h DE_48h-E2F6_MA0471.3 8 bp overlap

Motif DE_72h DE_72h-E2F6_MA0471.3 8 bp overlap

ChIP GM12878 ENCFF266FYW 265 bp overlap

EOMES 1 dataset

ChIP hESC GSE26097.EOMES.hESC 274 bp overlap

ChIP neural progenitor cell ENCFF018MKA 286 bp overlap

EZH2_phosphoT487 1 dataset

ChIP neural_progenitor ENCSR656MXA.EZH2_phosphoT487.neural_progenitor 212 bp overlap

FOXA1 1 dataset

ChIP breast-cancer_heregulin GSE101407.FOXA1.breast-cancer_heregulin 105 bp overlap

FOXA2 2 datasets

ChIP DE DE-FOXA2-1 604 bp overlap

ChIP DE DE-FOXA2-2 600 bp overlap

FOXS1 2 datasets

Motif DE_48h DE_48h-FOXS1_MA2118.1 8 bp overlap

Motif DE_72h DE_72h-FOXS1_MA2118.1 8 bp overlap

GABPB1 1 dataset

ChIP HepG2 ENCFF315AWN 70 bp overlap

GATA4 2 datasets

ChIP DE DE-GATA4-1 630 bp overlap

ChIP DE DE-GATA4-2 697 bp overlap

GATA6 9 datasets

ChIP DE DE-GATA6-1 598 bp overlap

ChIP DE DE-GATA6-2 705 bp overlap

ChIP DE_D1 S09-DE-d1-GATA6-exp1 355 bp overlap

ChIP DE_D1 S14-DE-d1-GATA6-exp1 370 bp overlap

ChIP DE_D1 S41-DE-d1-GATA6-exp2 388 bp overlap

ChIP DE_D2 S55-DE-d2-GATA6-exp2 671 bp overlap

ChIP HUES-8_DE_JNKi GSE109524.GATA6.HUES-8_DE_JNKi 385 bp overlap

ChIP HUES-8_DE_ctrl GSE109524.GATA6.HUES-8_DE_ctrl 394 bp overlap

ChIP endoderm_KO GSE117136.GATA6.endoderm_KO 603 bp overlap

HDAC1 1 dataset

ChIP HepG2 ENCFF304IEJ 53 bp overlap

HOXB13 1 dataset

ChIP G-401 GSE65381.HOXB13.G-401 252 bp overlap

KDM5B 1 dataset

ChIP HepG2 ENCFF706LUI 177 bp overlap

MEF2D 2 datasets

ChIP retina_Hu13 GSE137311.MEF2D.retina_Hu13 350 bp overlap

ChIP retina_Hu25 GSE137311.MEF2D.retina_Hu25 247 bp overlap

MITF 2 datasets

ChIP 501-mel_20ng_K243R GSE137522.MITF.501-mel_20ng_K243R 53 bp overlap

ChIP 501-mel_K243Q GSE137522.MITF.501-mel_K243Q 64 bp overlap

NEUROD1 5 datasets

ChIP D283-Med GSE92582.NEUROD1.D283-Med 338 bp overlap

ChIP D283-Med_shNEUROD1-1579 GSE92582.NEUROD1.D283-Med_shNEUROD1-1579 296 bp overlap

ChIP D341-Med_shGFP GSE92582.NEUROD1.D341-Med_shGFP 293 bp overlap

ChIP D341-Med_shNEUROD1-1154 GSE92582.NEUROD1.D341-Med_shNEUROD1-1154 209 bp overlap

ChIP D341-Med_shNEUROD1-1579 GSE92582.NEUROD1.D341-Med_shNEUROD1-1579 265 bp overlap

NFKB1 1 dataset

ChIP HEK293T_2KR GSE129618.NFKB1.HEK293T_2KR 214 bp overlap

Motif DE_72h DE_72h-OSR2_MA1646.2 8 bp overlap

ChIP retina_Hu7 GSE137311.OTX2.retina_Hu7 324 bp overlap

PATZ1 1 dataset

Motif DE_72h DE_72h-PATZ1_MA1961.2 11 bp overlap

PAX3-FOXO1 1 dataset

ChIP Hs-352-Sk GSE83725.PAX3-FOXO1.Hs-352-Sk 198 bp overlap

POU1F1 1 dataset

Motif DE_72h DE_72h-POU1F1_MA0784.3 14 bp overlap

POU2F1 1 dataset

Motif DE_72h DE_72h-POU2F1_MA0785.2 9 bp overlap

POU2F2 1 dataset

ChIP GM12891 ENCFF166YPP 236 bp overlap

POU3F1 1 dataset

Motif DE_72h DE_72h-POU3F1_MA0786.2 10 bp overlap

POU3F2 1 dataset

Motif DE_72h DE_72h-POU3F2_MA0787.1 12 bp overlap

POU3F3 1 dataset

Motif DE_72h DE_72h-POU3F3_MA0788.1 13 bp overlap

POU3F4 1 dataset

Motif DE_72h DE_72h-POU3F4_MA0789.1 9 bp overlap

POU5F1 1 dataset

ChIP DE_D1 DED1-OCT4_Batch_II 501 bp overlap

POU5F1B 1 dataset

Motif DE_72h DE_72h-POU5F1B_MA0792.1 9 bp overlap

PRDM14 1 dataset

ChIP NCCIT GSE71675.PRDM14.NCCIT 156 bp overlap

Plagl1 1 dataset

Motif DE_72h DE_72h-Plagl1_MA1615.2 8 bp overlap

ChIP retina_Hu22 GSE137311.RORB.retina_Hu22 346 bp overlap

SMAD2-3 3 datasets

ChIP HUES-8_DE GSE109524.SMAD2-3.HUES-8_DE 705 bp overlap

ChIP HUES-8_DE_JNKi GSE109524.SMAD2-3.HUES-8_DE_JNKi 359 bp overlap

ChIP HUES-8_DE_ctrl GSE109524.SMAD2-3.HUES-8_DE_ctrl 330 bp overlap

SMAD2_3 4 datasets

ChIP DE_D1 S12-DE-d1-SMAD2_3-exp1 323 bp overlap

ChIP DE_D1 S39-DE-d1-SMAD2_3-exp2 307 bp overlap

ChIP DE_D2 S01-DE-d2-SMAD2_3-exp1 705 bp overlap

ChIP DE_D2 S53-DE-d2-SMAD2_3-exp2 554 bp overlap

SMAD4 1 dataset

ChIP endoderm GSE29422.SMAD4.endoderm 182 bp overlap

SMARCA4 2 datasets

ChIP G-401_Dox GSE71504.SMARCA4.G-401_Dox 222 bp overlap

ChIP HS-SY-2_HA-tagged GSE108926.SMARCA4.HS-SY-2_HA-tagged 232 bp overlap

SMARCC1 4 datasets

ChIP G-401_Dox GSE71504.SMARCC1.G-401_Dox 275 bp overlap

ChIP G-401_NoDox GSE71504.SMARCC1.G-401_NoDox 201 bp overlap

ChIP HS-SY-2 GSE108025.SMARCC1.HS-SY-2 243 bp overlap

ChIP SYO-1_shRING1A-B GSE139053.SMARCC1.SYO-1_shRING1A-B 374 bp overlap

SMC1 3 datasets

ChIP DKO GSE131606.SMC1.DKO 80 bp overlap

ChIP HAP1_WaplKO-33 GSE94992.SMC1.HAP1_WaplKO-33 240 bp overlap

ChIP HCAEC GSE101921.SMC1.HCAEC 67 bp overlap

SOX17 1 dataset

ChIP DE_D2 DED2-SOX17_Batch_II 505 bp overlap

SOX17_M 1 dataset

ChIP DE_D2 DED2-SOX17-M_Batch_II 705 bp overlap

ChIP HNSC GSE69479.SOX2.HNSC 161 bp overlap

SOX21 1 dataset

ChIP neuroepithelilal-cells GSE110505.SOX21.neuroepithelilal-cells 527 bp overlap

SRSF3 1 dataset

ChIP K-562 GSE120104.SRSF3.K-562 237 bp overlap

SS18 4 datasets

ChIP SYO-1_shCt GSE139053.SS18.SYO-1_shCt 270 bp overlap

ChIP SYO-1_shCt GSE139053.SS18.SYO-1_shCt 339 bp overlap

ChIP SYO-1_shRING1A-B GSE139053.SS18.SYO-1_shRING1A-B 384 bp overlap

ChIP SYO-1_shRING1A-B GSE139053.SS18.SYO-1_shRING1A-B 53 bp overlap

ChIP H9_ENDODERM GSE60606.T.H9_ENDODERM 217 bp overlap

TFDP1 2 datasets

Motif DE_48h DE_48h-TFDP1_MA1122.2 8 bp overlap

Motif DE_72h DE_72h-TFDP1_MA1122.2 8 bp overlap

Motif DE_72h DE_72h-Wt1_MA1627.2 10 bp overlap

ZBED4 2 datasets

Motif DE_48h DE_48h-ZBED4_MA2328.1 10 bp overlap

Motif DE_72h DE_72h-ZBED4_MA2328.1 10 bp overlap

ZFP14 2 datasets

Motif DE_48h DE_48h-ZFP14_MA1972.1 15 bp overlap

Motif DE_72h DE_72h-ZFP14_MA1972.1 15 bp overlap

ZNF263 1 dataset

ChIP K-562 ENCSR000EWN.ZNF263.K-562 396 bp overlap

ZNF418 3 datasets

Motif DE_48h DE_48h-ZNF418_MA1980.1 15 bp overlap

Motif DE_72h DE_72h-ZNF418_MA1980.1 15 bp overlap

Motif DE_72h DE_72h-ZNF418_MA1980.1 15 bp overlap

ZNF585A 1 dataset

ChIP HEK293T GSE78099.ZNF585A.HEK293T 149 bp overlap

ZNF687 1 dataset

ChIP HepG2 ENCFF653WIX 56 bp overlap