Members of the F-box protein family, such as FBXL14, are characterized by an approximately 40-amino acid F-box motif. SCF complexes, formed by SKP1 (MIM 601434), cullin (see CUL1; MIM 603134), and F-box proteins, act as protein-ubiquitin ligases. F-box proteins interact with SKP1 through the F box, and they interact with ubiquitination targets through other protein interaction domains (Jin et al., 2004 [PubMed 15520277]).[supplied by OMIM, Mar 2008]
Transcription factors with Perturb-seq knockdown data for FBXL14. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = FBXL14 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of FBXL14, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr12:1,489,149–1,489,771 | 105.2 kb | Distal (>10kb) Multiome | 84 | |
| chr12:1,529,777–1,531,495 | 64.2 kb | Distal (>10kb) Multiome | 301 | |
| chr12:1,580,606–1,581,311 | 13.7 kb | Distal (>10kb) Multiome | 62 | |
| chr12:1,590,673–1,590,884 | 3.7 kb | Proximal (<10kb) | 143 | |
| chr12:1,593,421–1,595,263 | 196 bp | At TSS Multiome | 819 | |
| chr12:1,605,298–1,605,729 | 10.9 kb | Distal (>10kb) Multiome | 565 | |
| chr12:1,629,192–1,630,785 | 35.2 kb | Distal (>10kb) Multiome | 357 | |
| chr12:1,642,503–1,643,018 | 48.3 kb | Distal (>10kb) Multiome | 36 | |
| chr12:1,661,496–1,662,312 | 67.3 kb | Distal (>10kb) Multiome | 689 | |
| chr12:1,662,725–1,663,523 | 68.6 kb | Distal (>10kb) Multiome | 433 | |
| chr12:1,690,560–1,691,733 | 96.4 kb | Distal (>10kb) Multiome | 863 | |
| chr12:1,720,538–1,721,023 | 126.2 kb | Distal (>10kb) Multiome | 64 | |
| chr12:1,794,646–1,795,302 | 200.3 kb | Distal (>10kb) Multiome | 100 | |
| chr12:1,795,674–1,796,431 | 201.6 kb | Distal (>10kb) Multiome | 643 |
Genomic view of the FBXL14 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.