chr1 : 176,227,488 – 176,227,937
449 bp 80 TFs 2 linked genes
This 449 bp open chromatin element is linked to COP1-DT and COP1 and is bound by 80 transcription factors.
Linked Genes
2 genes
Gene↕ Expression Dist. to TSS↑ Distance↕ Link type↕
COP1-DT 20.1 kb Distal Multiome
COP1 21.3 kb Distal Multiome
Chromatin Accessibility

Genome Browser

Genomic view centred on this element. Tracks include ATAC-seq accessibility, RNA-seq expression, TF binding peaks, and element-to-gene loop arcs across the ESC → DE time course.

View limited to ±500 kb around this element.
For the full data, please see the UCSC track linked below.
chr1:176,222,488 – 176,232,937
This element Other elements Gene links ATAC-seq RNA-seq

Transcription factors with ChIP-seq peak overlap or TOBIAS motif footprint evidence at this element.

TF Binding
80 transcription factors
Source
Cell type
Arid3a 11 datasets
Motif DE_36h DE_36h-Arid3a_MA0151.1 6 bp overlap
Motif DE_36h DE_36h-Arid3a_MA0151.1 6 bp overlap
Motif DE_48h DE_48h-Arid3a_MA0151.1 6 bp overlap
Motif DE_48h DE_48h-Arid3a_MA0151.1 6 bp overlap
Motif DE_48h DE_48h-Arid3a_MA0151.1 6 bp overlap
Motif DE_60h DE_60h-Arid3a_MA0151.1 6 bp overlap
Motif DE_60h DE_60h-Arid3a_MA0151.1 6 bp overlap
Motif DE_60h DE_60h-Arid3a_MA0151.1 6 bp overlap
Motif DE_72h DE_72h-Arid3a_MA0151.1 6 bp overlap
Motif DE_72h DE_72h-Arid3a_MA0151.1 6 bp overlap
Motif DE_72h DE_72h-Arid3a_MA0151.1 6 bp overlap
BRD2 6 datasets
ChIP HCC1806_BAZ2BsiRNA GSE116879.BRD2.HCC1806_BAZ2BsiRNA 316 bp overlap
ChIP HCC1806_NTsiRNA GSE116879.BRD2.HCC1806_NTsiRNA 449 bp overlap
ChIP MDA-MB-231_BAZ2AsiRNA GSE116879.BRD2.MDA-MB-231_BAZ2AsiRNA 328 bp overlap
ChIP MDA-MB-231_BAZ2BsiRNA GSE116879.BRD2.MDA-MB-231_BAZ2BsiRNA 224 bp overlap
ChIP SUM159PT_DMSO GSE116879.BRD2.SUM159PT_DMSO 449 bp overlap
ChIP SUM159PT_MGSK2801 GSE116879.BRD2.SUM159PT_MGSK2801 358 bp overlap
BRD4 2 datasets
ChIP SUM159PT_DMSO_72h GSE87418.BRD4.SUM159PT_DMSO_72h 394 bp overlap
ChIP SUM159PT_scramble GSE131097.BRD4.SUM159PT_scramble 311 bp overlap
BRD7 1 dataset
ChIP SUM159PT_JQ1 GSE131097.BRD7.SUM159PT_JQ1 238 bp overlap
Bcl11B 1 dataset
Motif DE_60h DE_60h-Bcl11B_MA1989.2 9 bp overlap
CBX8 1 dataset
ChIP K-562 ENCSR000ATW.CBX8.K-562 222 bp overlap
CDX2 1 dataset
Motif DE_48h DE_48h-CDX2_MA0465.3 8 bp overlap
CDX4 1 dataset
Motif DE_48h DE_48h-CDX4_MA1473.2 9 bp overlap
CTCF 1 dataset
ChIP thyroid-gland ENCSR145HBC.CTCF.thyroid-gland 289 bp overlap
Crx 3 datasets
Motif DE_48h DE_48h-Crx_MA0467.3 6 bp overlap
Motif DE_60h DE_60h-Crx_MA0467.3 6 bp overlap
Motif DE_72h DE_72h-Crx_MA0467.3 6 bp overlap
EOMES 1 dataset
ChIP hESC GSE26097.EOMES.hESC 191 bp overlap
FOXA1 1 dataset
ChIP MCF-7_E2 GSE60270.FOXA1.MCF-7_E2 270 bp overlap
FOXA2 3 datasets
ChIP BJ1-hTERT_FOXA2_GATA4_Coexp GSE92491.FOXA2.BJ1-hTERT_FOXA2_GATA4_Coexp 235 bp overlap
ChIP DE DE-FOXA2-1 438 bp overlap
ChIP DE DE-FOXA2-2 304 bp overlap
FOXN3 1 dataset
Motif DE_60h DE_60h-FOXN3_MA1489.1 8 bp overlap
GATA1 1 dataset
ChIP K-562 GSE107726.GATA1.K-562 293 bp overlap
GATA1::TAL1 4 datasets
Motif DE_36h DE_36h-GATA1TAL1_MA0140.3 17 bp overlap
Motif DE_48h DE_48h-GATA1TAL1_MA0140.3 17 bp overlap
Motif DE_60h DE_60h-GATA1TAL1_MA0140.3 17 bp overlap
Motif DE_72h DE_72h-GATA1TAL1_MA0140.3 17 bp overlap
GATA2 1 dataset
ChIP TF1 GSE73207.GATA2.TF1 261 bp overlap
GATA3 1 dataset
ChIP MCF-7_E2_Dex GSE81510.GATA3.MCF-7_E2_Dex 254 bp overlap
GATA4 6 datasets
ChIP DE DE-GATA4-1 449 bp overlap
ChIP DE DE-GATA4-2 449 bp overlap
ChIP Hep-G2 GSE135714.GATA4.Hep-G2 449 bp overlap
ChIP foregut GSE117136.GATA4.foregut 449 bp overlap
ChIP pancreatic-progenitor GSE117136.GATA4.pancreatic-progenitor 398 bp overlap
ChIP pancreatic-progenitor_PP1 GSE104840.GATA4.pancreatic-progenitor_PP1 326 bp overlap
GATA6 10 datasets
ChIP AGS GSE51705.GATA6.AGS 143 bp overlap
ChIP DE DE-GATA6-1 411 bp overlap
ChIP DE DE-GATA6-2 449 bp overlap
ChIP DE_D1 S14-DE-d1-GATA6-exp1 289 bp overlap
ChIP DE_D2 S55-DE-d2-GATA6-exp2 449 bp overlap
ChIP HUES-8_DE_JNKi GSE109524.GATA6.HUES-8_DE_JNKi 323 bp overlap
ChIP endoderm_KO GSE117136.GATA6.endoderm_KO 449 bp overlap
ChIP foregut GSE117136.GATA6.foregut 398 bp overlap
ChIP pancreatic-progenitor GSE117136.GATA6.pancreatic-progenitor 449 bp overlap
ChIP pancreatic-progenitor_PP1 GSE104840.GATA6.pancreatic-progenitor_PP1 386 bp overlap
GFI1 1 dataset
Motif DE_60h DE_60h-GFI1_MA0038.3 11 bp overlap
GSC 3 datasets
Motif DE_48h DE_48h-GSC_MA0648.2 6 bp overlap
Motif DE_60h DE_60h-GSC_MA0648.2 6 bp overlap
Motif DE_72h DE_72h-GSC_MA0648.2 6 bp overlap
GSC2 3 datasets
Motif DE_48h DE_48h-GSC2_MA0891.2 6 bp overlap
Motif DE_60h DE_60h-GSC2_MA0891.2 6 bp overlap
Motif DE_72h DE_72h-GSC2_MA0891.2 6 bp overlap
Gfi1B 1 dataset
Motif DE_60h DE_60h-Gfi1B_MA0483.2 10 bp overlap
HNF1A 4 datasets
Motif DE_36h DE_36h-HNF1A_MA0046.3 13 bp overlap
Motif DE_48h DE_48h-HNF1A_MA0046.3 13 bp overlap
Motif DE_60h DE_60h-HNF1A_MA0046.3 13 bp overlap
Motif DE_72h DE_72h-HNF1A_MA0046.3 13 bp overlap
HNF1B 4 datasets
Motif DE_36h DE_36h-HNF1B_MA0153.2 13 bp overlap
Motif DE_48h DE_48h-HNF1B_MA0153.2 13 bp overlap
Motif DE_60h DE_60h-HNF1B_MA0153.2 13 bp overlap
Motif DE_72h DE_72h-HNF1B_MA0153.2 13 bp overlap
HOXB4 4 datasets
Motif DE_36h DE_36h-HOXB4_MA1499.2 6 bp overlap
Motif DE_48h DE_48h-HOXB4_MA1499.2 6 bp overlap
Motif DE_60h DE_60h-HOXB4_MA1499.2 6 bp overlap
Motif DE_72h DE_72h-HOXB4_MA1499.2 6 bp overlap
HOXC4 4 datasets
Motif DE_36h DE_36h-HOXC4_MA1504.2 6 bp overlap
Motif DE_48h DE_48h-HOXC4_MA1504.2 6 bp overlap
Motif DE_60h DE_60h-HOXC4_MA1504.2 6 bp overlap
Motif DE_72h DE_72h-HOXC4_MA1504.2 6 bp overlap
HOXD4 4 datasets
Motif DE_36h DE_36h-HOXD4_MA1507.2 6 bp overlap
Motif DE_48h DE_48h-HOXD4_MA1507.2 6 bp overlap
Motif DE_60h DE_60h-HOXD4_MA1507.2 6 bp overlap
Motif DE_72h DE_72h-HOXD4_MA1507.2 6 bp overlap
Hoxa13 1 dataset
Motif DE_48h DE_48h-Hoxa13_MA0650.4 8 bp overlap
Hoxd13 1 dataset
Motif DE_48h DE_48h-Hoxd13_MA0909.4 7 bp overlap
IRF4 3 datasets
Motif DE_48h DE_48h-IRF4_MA1419.2 14 bp overlap
Motif DE_60h DE_60h-IRF4_MA1419.2 14 bp overlap
Motif DE_72h DE_72h-IRF4_MA1419.2 14 bp overlap
IRF6 3 datasets
Motif DE_48h DE_48h-IRF6_MA1509.1 9 bp overlap
Motif DE_60h DE_60h-IRF6_MA1509.1 9 bp overlap
Motif DE_72h DE_72h-IRF6_MA1509.1 9 bp overlap
IRF8 3 datasets
Motif DE_48h DE_48h-IRF8_MA0652.2 13 bp overlap
Motif DE_60h DE_60h-IRF8_MA0652.2 13 bp overlap
Motif DE_72h DE_72h-IRF8_MA0652.2 13 bp overlap
IRF9 3 datasets
Motif DE_48h DE_48h-IRF9_MA0653.1 15 bp overlap
Motif DE_60h DE_60h-IRF9_MA0653.1 15 bp overlap
Motif DE_72h DE_72h-IRF9_MA0653.1 15 bp overlap
LYL1 1 dataset
ChIP TSU-1621MT GSE60477.LYL1.TSU-1621MT 260 bp overlap
NFYA 2 datasets
Motif DE_48h DE_48h-NFYA_MA0060.4 8 bp overlap
Motif DE_72h DE_72h-NFYA_MA0060.4 8 bp overlap
NFYC 2 datasets
Motif DE_48h DE_48h-NFYC_MA1644.2 7 bp overlap
Motif DE_72h DE_72h-NFYC_MA1644.2 7 bp overlap
NRL 4 datasets
Motif DE_36h DE_36h-NRL_MA0842.3 12 bp overlap
Motif DE_48h DE_48h-NRL_MA0842.3 12 bp overlap
Motif DE_60h DE_60h-NRL_MA0842.3 12 bp overlap
Motif DE_72h DE_72h-NRL_MA0842.3 12 bp overlap
Nr1h3::Rxra 2 datasets
Motif DE_48h DE_48h-Nr1h3Rxra_MA0494.2 16 bp overlap
Motif DE_72h DE_72h-Nr1h3Rxra_MA0494.2 16 bp overlap
OTX1 3 datasets
Motif DE_48h DE_48h-OTX1_MA0711.2 6 bp overlap
Motif DE_60h DE_60h-OTX1_MA0711.2 6 bp overlap
Motif DE_72h DE_72h-OTX1_MA0711.2 6 bp overlap
PBX1 2 datasets
Motif DE_48h DE_48h-PBX1_MA0070.2 9 bp overlap
Motif DE_72h DE_72h-PBX1_MA0070.2 9 bp overlap
PITX1 3 datasets
Motif DE_48h DE_48h-PITX1_MA0682.3 6 bp overlap
Motif DE_60h DE_60h-PITX1_MA0682.3 6 bp overlap
Motif DE_72h DE_72h-PITX1_MA0682.3 6 bp overlap
PITX2 3 datasets
Motif DE_48h DE_48h-PITX2_MA1547.2 8 bp overlap
Motif DE_60h DE_60h-PITX2_MA1547.2 8 bp overlap
Motif DE_72h DE_72h-PITX2_MA1547.2 8 bp overlap
PITX3 3 datasets
Motif DE_48h DE_48h-PITX3_MA0714.2 6 bp overlap
Motif DE_60h DE_60h-PITX3_MA0714.2 6 bp overlap
Motif DE_72h DE_72h-PITX3_MA0714.2 6 bp overlap
POU2F1::SOX2 4 datasets
Motif DE_36h DE_36h-POU2F1SOX2_MA1962.1 17 bp overlap
Motif DE_48h DE_48h-POU2F1SOX2_MA1962.1 17 bp overlap
Motif DE_60h DE_60h-POU2F1SOX2_MA1962.1 17 bp overlap
Motif DE_72h DE_72h-POU2F1SOX2_MA1962.1 17 bp overlap
POU3F3 4 datasets
Motif DE_36h DE_36h-POU3F3_MA0788.1 13 bp overlap
Motif DE_48h DE_48h-POU3F3_MA0788.1 13 bp overlap
Motif DE_60h DE_60h-POU3F3_MA0788.1 13 bp overlap
Motif DE_72h DE_72h-POU3F3_MA0788.1 13 bp overlap
POU4F1 4 datasets
Motif DE_36h DE_36h-POU4F1_MA0790.2 12 bp overlap
Motif DE_48h DE_48h-POU4F1_MA0790.2 12 bp overlap
Motif DE_60h DE_60h-POU4F1_MA0790.2 12 bp overlap
Motif DE_72h DE_72h-POU4F1_MA0790.2 12 bp overlap
POU4F2 4 datasets
Motif DE_36h DE_36h-POU4F2_MA0683.2 15 bp overlap
Motif DE_48h DE_48h-POU4F2_MA0683.2 15 bp overlap
Motif DE_60h DE_60h-POU4F2_MA0683.2 15 bp overlap
Motif DE_72h DE_72h-POU4F2_MA0683.2 15 bp overlap
POU4F3 4 datasets
Motif DE_36h DE_36h-POU4F3_MA0791.2 12 bp overlap
Motif DE_48h DE_48h-POU4F3_MA0791.2 12 bp overlap
Motif DE_60h DE_60h-POU4F3_MA0791.2 12 bp overlap
Motif DE_72h DE_72h-POU4F3_MA0791.2 12 bp overlap
POU5F1 3 datasets
ChIP NCCIT GSE36134.POU5F1.NCCIT 449 bp overlap
ChIP NCCIT_SNF5 GSE36134.POU5F1.NCCIT_SNF5 449 bp overlap
ChIP hESC_NAIVE GSE69646.POU5F1.hESC_NAIVE 449 bp overlap
POU6F2 3 datasets
Motif DE_48h DE_48h-POU6F2_MA0793.2 9 bp overlap
Motif DE_60h DE_60h-POU6F2_MA0793.2 9 bp overlap
Motif DE_72h DE_72h-POU6F2_MA0793.2 9 bp overlap
PRDM1 2 datasets
Motif DE_48h DE_48h-PRDM1_MA0508.4 7 bp overlap
Motif DE_72h DE_72h-PRDM1_MA0508.4 7 bp overlap
Pou5f1::Sox2 4 datasets
Motif DE_36h DE_36h-Pou5f1Sox2_MA0142.1 15 bp overlap
Motif DE_48h DE_48h-Pou5f1Sox2_MA0142.1 15 bp overlap
Motif DE_60h DE_60h-Pou5f1Sox2_MA0142.1 15 bp overlap
Motif DE_72h DE_72h-Pou5f1Sox2_MA0142.1 15 bp overlap
RAD21 1 dataset
ChIP HAP1 GSE152721.RAD21.HAP1 156 bp overlap
RBPJ 3 datasets
Motif DE_48h DE_48h-RBPJ_MA1116.2 6 bp overlap
Motif DE_60h DE_60h-RBPJ_MA1116.2 6 bp overlap
Motif DE_72h DE_72h-RBPJ_MA1116.2 6 bp overlap
RFX5 2 datasets
Motif DE_48h DE_48h-RFX5_MA0510.3 14 bp overlap
Motif DE_72h DE_72h-RFX5_MA0510.3 14 bp overlap
RFX7 3 datasets
Motif DE_48h DE_48h-RFX7_MA1554.2 8 bp overlap
Motif DE_60h DE_60h-RFX7_MA1554.2 8 bp overlap
Motif DE_72h DE_72h-RFX7_MA1554.2 8 bp overlap
RHOXF1 3 datasets
Motif DE_48h DE_48h-RHOXF1_MA0719.2 6 bp overlap
Motif DE_60h DE_60h-RHOXF1_MA0719.2 6 bp overlap
Motif DE_72h DE_72h-RHOXF1_MA0719.2 6 bp overlap
SATB1 1 dataset
ChIP MCF-10A_ICRF GSE123292.SATB1.MCF-10A_ICRF 56 bp overlap
SIX1 2 datasets
Motif DE_48h DE_48h-SIX1_MA1118.2 9 bp overlap
Motif DE_72h DE_72h-SIX1_MA1118.2 9 bp overlap
SIX2 2 datasets
Motif DE_48h DE_48h-SIX2_MA1119.2 11 bp overlap
Motif DE_72h DE_72h-SIX2_MA1119.2 11 bp overlap
SMAD2-3 1 dataset
ChIP HUES-8_DE GSE109524.SMAD2-3.HUES-8_DE 299 bp overlap
SMARCB1 1 dataset
ChIP proliferating-human-fibroblast GSE131711.SMARCB1.proliferating-human-fibroblast 218 bp overlap
SMARCE1 1 dataset
ChIP HMLE-Twist-ER_125nM_4OHT GSE96933.SMARCE1.HMLE-Twist-ER_125nM_4OHT 185 bp overlap
SOX17_M 1 dataset
ChIP DE_D2 DED2-SOX17-M_Batch_II 289 bp overlap
SOX2 1 dataset
ChIP hESC GSE18292.SOX2.hESC 127 bp overlap
SPI1 1 dataset
ChIP BDMC_donorH GSE128834.SPI1.BDMC_donorH 161 bp overlap
STAT1::STAT2 3 datasets
Motif DE_48h DE_48h-STAT1STAT2_MA0517.2 13 bp overlap
Motif DE_60h DE_60h-STAT1STAT2_MA0517.2 13 bp overlap
Motif DE_72h DE_72h-STAT1STAT2_MA0517.2 13 bp overlap
STAT3 1 dataset
ChIP HepaRG_sodium-oleate GSE89157.STAT3.HepaRG_sodium-oleate 101 bp overlap
ZFP42 2 datasets
Motif DE_48h DE_48h-ZFP42_MA1651.2 13 bp overlap
Motif DE_72h DE_72h-ZFP42_MA1651.2 13 bp overlap
ZIM3 2 datasets
Motif DE_48h DE_48h-ZIM3_MA1709.2 11 bp overlap
Motif DE_72h DE_72h-ZIM3_MA1709.2 11 bp overlap
ZNF214 2 datasets
Motif DE_48h DE_48h-ZNF214_MA1975.2 13 bp overlap
Motif DE_72h DE_72h-ZNF214_MA1975.2 13 bp overlap
ZNF319 1 dataset
ChIP K-562 ENCSR231PDA.ZNF319.K-562 262 bp overlap
ZNF324 2 datasets
Motif DE_48h DE_48h-ZNF324_MA1977.2 14 bp overlap
Motif DE_72h DE_72h-ZNF324_MA1977.2 14 bp overlap
ZNF384 1 dataset
Motif DE_60h DE_60h-ZNF384_MA1125.2 8 bp overlap
ZNF664 1 dataset
ChIP HEK293 ENCFF343XSW 51 bp overlap
ZNF677 3 datasets
Motif DE_48h DE_48h-ZNF677_MA2101.1 12 bp overlap
Motif DE_60h DE_60h-ZNF677_MA2101.1 12 bp overlap
Motif DE_72h DE_72h-ZNF677_MA2101.1 12 bp overlap
ZNF707 3 datasets
Motif DE_48h DE_48h-ZNF707_MA1715.1 15 bp overlap
Motif DE_60h DE_60h-ZNF707_MA1715.1 15 bp overlap
Motif DE_72h DE_72h-ZNF707_MA1715.1 15 bp overlap
ZNF830 1 dataset
ChIP K-562 ENCSR033NQK.ZNF830.K-562 126 bp overlap
Huangfu Lab · Publications · Resources · Contact