Predicted to enable nucleic acid binding activity and zinc ion binding activity. Predicted to be involved in several processes, including mitotic DNA integrity checkpoint signaling; nuclear DNA replication; and preantral ovarian follicle growth. Predicted to act upstream of or within several processes, including blastocyst growth; chromosome organization; and intestinal epithelial structure maintenance. Predicted to be located in nucleoplasm. Predicted to be part of spliceosomal complex. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for ZNF830. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ZNF830 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ZNF830, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr17:34,742,533–34,742,963 | 218.8 kb | Distal (>10kb) Multiome | 19 | |
| chr17:34,798,552–34,799,335 | 162.7 kb | Distal (>10kb) Multiome | 89 | |
| chr17:34,886,833–34,887,368 | 74.5 kb | Distal (>10kb) Multiome | 205 | |
| chr17:34,961,027–34,961,847 | 72 bp | At TSS Multiome | 793 | |
| chr17:34,980,134–34,981,317 | 19.1 kb | Distal (>10kb) Multiome | 855 | |
| chr17:35,063,589–35,064,217 | 102.3 kb | Distal (>10kb) Multiome | 813 | |
| chr17:35,088,426–35,090,139 | 127.8 kb | Distal (>10kb) Multiome | 805 | |
| chr17:35,119,302–35,120,200 | 158.2 kb | Distal (>10kb) Multiome | 761 | |
| chr17:35,141,908–35,142,655 | 180.8 kb | Distal (>10kb) Multiome | 873 | |
| chr17:35,242,191–35,243,858 | 281.4 kb | Distal (>10kb) Multiome | 590 |
Genomic view of the ZNF830 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.