This gene represents a basic helix-loop-helix transcription factor. The encoded protein may play roles in blood vessel maturation and hematopoeisis. A translocation between this locus and the T cell receptor beta locus (GeneID 6957) on chromosome 7 has been associated with acute lymphoblastic leukemia. [provided by RefSeq, Sep 2010]
Transcription factors with Perturb-seq knockdown data for LYL1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = LYL1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of LYL1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr19:13,093,620–13,094,260 | 8.6 kb | Proximal (<10kb) | 411 | |
| chr19:13,095,079–13,096,870 | 6.0 kb | Proximal (<10kb) | 501 | |
| chr19:13,099,220–13,099,614 | 3.2 kb | Proximal (<10kb) | 324 | |
| chr19:13,102,495–13,103,074 | at TSS | At TSS | 606 | |
| chr19:13,104,442–13,104,804 | 1.6 kb | Proximal (<10kb) | 392 |
Genomic view of the LYL1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.