chr6:2,913,547–2,914,632

chr6 : 2,913,547 – 2,914,632

1,085 bp 67 TFs 8 linked genes

This 1.1 kb open chromatin element is linked to 8 target genes and is bound by 67 transcription factors.

Linked Genes

8 genes

Gene	Expression	Dist. to TSS	Distance	Link type
SERPINB9		10.5 kb	Distal	Multiome
SERPINB6		57.4 kb	Distal	Multiome
SERPINB1		72.0 kb	Distal	Multiome
NQO2		74.8 kb	Distal	Multiome+HiCAR
WRNIP1		148.4 kb	Distal	Multiome
RIPK1		150.0 kb	Distal	Multiome
BPHL		204.8 kb	Distal	Multiome
TUBB2A		243.7 kb	Distal	Multiome

Chromatin Accessibility

Genome Browser

Genomic view centred on this element. Tracks include ATAC-seq accessibility, RNA-seq expression, TF binding peaks, and element-to-gene loop arcs across the ESC → DE time course.

Transcription factors with ChIP-seq peak overlap or TOBIAS motif footprint evidence at this element.

TF Binding

67 transcription factors

ARID1A 1 dataset

ChIP MCF-7_4-hydroxytamoxifen GSE123284.ARID1A.MCF-7_4-hydroxytamoxifen 302 bp overlap

ASCL1 1 dataset

Motif DE_72h DE_72h-ASCL1_MA1631.2 9 bp overlap

ChIP Hep-G2 ENCSR402ZCY.ATF3.Hep-G2 143 bp overlap

BCL11A 1 dataset

ChIP CD34_Day3_30min GSE104676.BCL11A.CD34_Day3_30min 56 bp overlap

ChIP HUES-64 GSE104059.BRD1.HUES-64 218 bp overlap

ChIP H-1_DE GSE126661.BRD3.H-1_DE 517 bp overlap

ChIP HAP1 GSE108387.BRD4.HAP1 683 bp overlap

CBFA2T2 2 datasets

ChIP K-562 ENCSR699PVC.CBFA2T2.K-562 223 bp overlap

ChIP K562 ENCFF963TXY 381 bp overlap

CBFA2T3 2 datasets

ChIP K-562 ENCSR697YLJ.CBFA2T3.K-562 347 bp overlap

ChIP K562 ENCFF673OEZ 191 bp overlap

CDKN1B 1 dataset

ChIP MDA-MB-231_p27CK-DD GSE112444.CDKN1B.MDA-MB-231_p27CK-DD 193 bp overlap

CEBPB 1 dataset

ChIP MV4-11 GSE88746.CEBPB.MV4-11 256 bp overlap

CREBBP 1 dataset

ChIP NCI-H3396 GSE32349.CREBBP.NCI-H3396 121 bp overlap

Motif DE_72h DE_72h-CTCF_MA0139.2 15 bp overlap

ChIP AMLPZ12 GSE23730.ERG.AMLPZ12 89 bp overlap

ESR1 6 datasets

ChIP MCF-7_PROG GSE68355.ESR1.MCF-7_PROG 237 bp overlap

ChIP MCF-7_jc5852 GSE126004.ESR1.MCF-7_jc5852 261 bp overlap

ChIP T-47D_Y537S_E2 GSE148277.ESR1.T-47D_Y537S_E2 235 bp overlap

ChIP U2OS_100nM-E2 GSE151039.ESR1.U2OS_100nM-E2 211 bp overlap

ChIP U2OS_10nM-E2 GSE151039.ESR1.U2OS_10nM-E2 152 bp overlap

ChIP U2OS_10nM-E2-B GSE151039.ESR1.U2OS_10nM-E2-B 249 bp overlap

ChIP RH30_DMSO GSE85169.EZH2.RH30_DMSO 295 bp overlap

FIGLA 1 dataset

Motif DE_72h DE_72h-FIGLA_MA0820.2 6 bp overlap

FOSL2 1 dataset

ChIP HepG2 ENCFF548CXY 327 bp overlap

FOXA1 10 datasets

ChIP A-549 ENCSR000BPX.FOXA1.A-549 204 bp overlap

ChIP A-549 ENCSR000BRD.FOXA1.A-549 149 bp overlap

ChIP CFPAC-1 GSE119930.FOXA1.CFPAC-1 299 bp overlap

ChIP LS180 GSE140533.FOXA1.LS180 63 bp overlap

ChIP MCF-7 GSE81714.FOXA1.MCF-7 223 bp overlap

ChIP MCF-7_1117 GSE124667.FOXA1.MCF-7_1117 182 bp overlap

ChIP MCF-7_E2 GSE23852.FOXA1.MCF-7_E2 128 bp overlap

ChIP MCF-7_ETOH GSE23852.FOXA1.MCF-7_ETOH 155 bp overlap

ChIP MCF-7_JC4690 GSE126004.FOXA1.MCF-7_JC4690 213 bp overlap

ChIP pancreatic-progenitor_PP1 GSE104840.FOXA1.pancreatic-progenitor_PP1 370 bp overlap

FOXA2 8 datasets

ChIP CFPAC-1_EV GSE119930.FOXA2.CFPAC-1_EV 366 bp overlap

ChIP CFPAC-1_HOXB8-OE GSE119930.FOXA2.CFPAC-1_HOXB8-OE 249 bp overlap

ChIP Caco-2 GSE66218.FOXA2.Caco-2 125 bp overlap

ChIP DE DE-FOXA2-1 501 bp overlap

ChIP DE DE-FOXA2-1 392 bp overlap

ChIP DE DE-FOXA2-2 474 bp overlap

ChIP DE DE-FOXA2-2 375 bp overlap

ChIP pancreatic-progenitor_PP1 GSE104840.FOXA2.pancreatic-progenitor_PP1 195 bp overlap

GATA1::TAL1 1 dataset

Motif DE_72h DE_72h-GATA1TAL1_MA0140.3 17 bp overlap

GATA4 6 datasets

ChIP DE DE-GATA4-1 522 bp overlap

ChIP DE DE-GATA4-2 559 bp overlap

ChIP DE DE-GATA4-2 242 bp overlap

ChIP foregut GSE117136.GATA4.foregut 400 bp overlap

ChIP pancreatic-progenitor GSE117136.GATA4.pancreatic-progenitor 572 bp overlap

ChIP pancreatic-progenitor_PP1 GSE104840.GATA4.pancreatic-progenitor_PP1 581 bp overlap

GATA6 17 datasets

ChIP AGS GSE51705.GATA6.AGS 374 bp overlap

ChIP Caco-2_PROLIF GSE23436.GATA6.Caco-2_PROLIF 112 bp overlap

ChIP DE DE-GATA6-1 526 bp overlap

ChIP DE DE-GATA6-2 719 bp overlap

ChIP DE DE-GATA6-2 313 bp overlap

ChIP DE_D1 S09-DE-d1-GATA6-exp1 597 bp overlap

ChIP DE_D1 S14-DE-d1-GATA6-exp1 619 bp overlap

ChIP DE_D1 S41-DE-d1-GATA6-exp2 596 bp overlap

ChIP DE_D2 S55-DE-d2-GATA6-exp2 514 bp overlap

ChIP HUES-8_DE_JNKi GSE109524.GATA6.HUES-8_DE_JNKi 653 bp overlap

ChIP HUES-8_DE_ctrl GSE109524.GATA6.HUES-8_DE_ctrl 638 bp overlap

ChIP PATU8988 GSE47535.GATA6.PATU8988 267 bp overlap

ChIP YCC-3 GSE51705.GATA6.YCC-3 124 bp overlap

ChIP endoderm_KO GSE117136.GATA6.endoderm_KO 533 bp overlap

ChIP foregut GSE117136.GATA6.foregut 363 bp overlap

ChIP pancreatic-progenitor GSE117136.GATA6.pancreatic-progenitor 470 bp overlap

ChIP pancreatic-progenitor_PP1 GSE104840.GATA6.pancreatic-progenitor_PP1 540 bp overlap

ChIP K-562 ENCSR197ALX.HDGF.K-562 245 bp overlap

IKZF1 1 dataset

ChIP K-562 ENCSR395HWC.IKZF1.K-562 609 bp overlap

ChIP DE_D1 S08-DE-d1-JUN-exp1 434 bp overlap

ChIP DE_D1 S13-DE-d1-JUN-exp1 307 bp overlap

ChIP DE_D1 S40-DE-d1-JUN-exp2 400 bp overlap

ChIP DE_D2 S02-DE-d2-JUN-exp1 544 bp overlap

ChIP DE_D2 S54-DE-d2-JUN-exp2 336 bp overlap

ChIP HAEC_oxpapc_4h GSE89970.JUN.HAEC_oxpapc_4h 130 bp overlap

ChIP HUES-8_DE_ctrl GSE109524.JUN.HUES-8_DE_ctrl 448 bp overlap

KLF1 3 datasets

ChIP HEK293 ENCFF159QSW 291 bp overlap

ChIP HEK293 ENCSR859BMR.KLF1.HEK293 415 bp overlap

ChIP HEK293 GSE76494.KLF1.HEK293 244 bp overlap

KLF4 4 datasets

ChIP HAP1 GSE130417.KLF4.HAP1 255 bp overlap

ChIP MCF-7 ENCFF948KTQ 298 bp overlap

ChIP MCF-7 ENCFF948KTQ 275 bp overlap

ChIP MCF-7 GSE41561.KLF4.MCF-7 262 bp overlap

KLF5 2 datasets

ChIP ESO-26 GSE132680.KLF5.ESO-26 266 bp overlap

ChIP GP5D GSE51234.KLF5.GP5D 237 bp overlap

ChIP GBM1A GSE62211.KLF9.GBM1A 86 bp overlap

ChIP Hep-G2 ENCSR108MKR.MNX1.Hep-G2 154 bp overlap

ChIP Hep-G2 ENCSR441KFW.MXD4.Hep-G2 129 bp overlap

ChIP Hep-G2 ENCSR398TMP.MYNN.Hep-G2 143 bp overlap

NR3C1 1 dataset

ChIP A-549 ENCSR000BJR.NR3C1.A-549 131 bp overlap

Nr2e3 1 dataset

Motif DE_72h DE_72h-Nr2e3_MA0164.2 6 bp overlap

ONECUT1 4 datasets

ChIP H9 ERP004206.ONECUT1.H9 202 bp overlap

ChIP Hep-G2 ENCSR956OSX.ONECUT1.Hep-G2 251 bp overlap

ChIP HepG2 ENCFF243FIR 284 bp overlap

ChIP pancreatic-progenitor_PP1 GSE104840.ONECUT1.pancreatic-progenitor_PP1 471 bp overlap

ONECUT2 1 dataset

ChIP AGS_Overexpression GSE113045.ONECUT2.AGS_Overexpression 271 bp overlap

ChIP hiPSC GSE125768.PDX1.hiPSC 231 bp overlap

ChIP MCF-7_PROG GSE68355.PGR.MCF-7_PROG 302 bp overlap

ChIP MCF-7_R5020 GSE68355.PGR.MCF-7_R5020 215 bp overlap

PLAG1 1 dataset

ChIP K-562 GSE111469.PLAG1.K-562 232 bp overlap

POU2F1::SOX2 1 dataset

Motif DE_72h DE_72h-POU2F1SOX2_MA1962.1 17 bp overlap

POU5F1 2 datasets

ChIP DE_D1 DED1-OCT4_Batch_II 245 bp overlap

ChIP hESC_NAIVE GSE69646.POU5F1.hESC_NAIVE 298 bp overlap

POU5F1_M 1 dataset

ChIP DE_D1 DED1-OCT4-M_Batch_II 651 bp overlap

Pou5f1::Sox2 1 dataset

Motif DE_72h DE_72h-Pou5f1Sox2_MA0142.1 15 bp overlap

SMAD2_3 5 datasets

ChIP DE_D1 S07-DE-d1-SMAD2_3-exp1 689 bp overlap

ChIP DE_D1 S12-DE-d1-SMAD2_3-exp1 618 bp overlap

ChIP DE_D1 S39-DE-d1-SMAD2_3-exp2 430 bp overlap

ChIP DE_D2 S01-DE-d2-SMAD2_3-exp1 557 bp overlap

ChIP DE_D2 S53-DE-d2-SMAD2_3-exp2 620 bp overlap

SMAD4 2 datasets

ChIP Caco-2 GSE112946.SMAD4.Caco-2 270 bp overlap

ChIP endoderm GSE29422.SMAD4.endoderm 197 bp overlap

SMARCC1 2 datasets

ChIP DE_D1 S15-DE-d1-BAF155-exp1 211 bp overlap

ChIP DE_D1 S15-DE-d1-BAF155-exp1 329 bp overlap

SNAI1 1 dataset

Motif DE_72h DE_72h-SNAI1_MA1558.2 7 bp overlap

SNAI3 1 dataset

Motif DE_72h DE_72h-SNAI3_MA1559.2 9 bp overlap

SOX17_M 1 dataset

ChIP DE_D2 DED2-SOX17-M_Batch_II 464 bp overlap

ChIP LK2_GFP GSE137459.SOX2.LK2_GFP 171 bp overlap

SUZ12 1 dataset

ChIP ProEs GSE59087.SUZ12.ProEs 125 bp overlap

ChIP K-562_enCRISPRi-LK GSE132212.TAL1.K-562_enCRISPRi-LK 159 bp overlap

TCF12 2 datasets

Motif DE_72h DE_72h-TCF12_MA1648.2 7 bp overlap

ChIP WA01 ENCSR000BIT.TCF12.WA01 114 bp overlap

TCF3 4 datasets

Motif DE_72h DE_72h-TCF3_MA0522.4 7 bp overlap

ChIP K-562 ENCSR970OJY.TCF3.K-562 138 bp overlap

ChIP K562 ENCFF319QZT 381 bp overlap

ChIP Kasumi-1 GSE43834.TCF3.Kasumi-1 242 bp overlap

TFAP4 3 datasets

ChIP DLD-1 GSE46935.TFAP4.DLD-1 251 bp overlap

ChIP Hep-G2 ENCSR103SZL.TFAP4.Hep-G2 177 bp overlap

ChIP HepG2 ENCFF932XOY 336 bp overlap

TRIM28 1 dataset

ChIP hESC GSE115387.TRIM28.hESC 208 bp overlap

ZBTB21 1 dataset

ChIP Hep-G2 ENCSR549PAU.ZBTB21.Hep-G2 216 bp overlap

ZBTB7B 1 dataset

ChIP Hep-G2 ENCSR322ULL.ZBTB7B.Hep-G2 134 bp overlap

Motif DE_72h DE_72h-ZEB1_MA0103.4 6 bp overlap

ZEB2 3 datasets

ChIP K-562 ENCSR004GKA.ZEB2.K-562 342 bp overlap

ChIP K-562 ENCSR322CFO.ZEB2.K-562 251 bp overlap

ChIP K562 ENCFF795CMH 477 bp overlap

ChIP HEK293T_FLAG GSE145160.ZFX.HEK293T_FLAG 286 bp overlap

ZNF274 1 dataset

ChIP Hep-G2 ENCSR871VNN.ZNF274.Hep-G2 294 bp overlap

ZNF407 1 dataset

ChIP Hep-G2 ENCSR005WGY.ZNF407.Hep-G2 178 bp overlap

ZNF598 1 dataset

ChIP Hep-G2 ENCSR173NAL.ZNF598.Hep-G2 295 bp overlap

ZNF711 1 dataset

ChIP HEK293T GSE145160.ZNF711.HEK293T 406 bp overlap

ZNF736 1 dataset

ChIP HEK293T GSE78099.ZNF736.HEK293T 124 bp overlap