This gene encodes a member of the thioredoxin family of enzymes. It is a cytosolic and ubiquitously expressed flavoprotein that catalyzes the two-electron reduction of quinone substrates and uses dihydronicotinamide riboside as a reducing coenzyme. Mutations in this gene have been associated with neurodegenerative diseases and several cancers. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2014]
Transcription factors with Perturb-seq knockdown data for NQO2. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = NQO2 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of NQO2, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr6:1,604,125–1,605,503 | 1384.1 kb | Distal (>10kb) Multiome HiCAR | 591 | |
| chr6:1,606,436–1,607,329 | 1381.8 kb | Distal (>10kb) Multiome HiCAR | 251 | |
| chr6:1,607,558–1,608,252 | 1380.7 kb | Distal (>10kb) Multiome HiCAR | 448 | |
| chr6:1,608,357–1,612,111 | 1378.8 kb | Distal (>10kb) Multiome HiCAR | 614 | |
| chr6:2,764,624–2,766,543 | 223.4 kb | Distal (>10kb) Multiome | 1055 | |
| chr6:2,841,174–2,842,113 | 147.0 kb | Distal (>10kb) Multiome HiCAR | 959 | |
| chr6:2,875,264–2,877,978 | 113.1 kb | Distal (>10kb) Multiome | 812 | |
| chr6:2,902,554–2,903,750 | 85.3 kb | Distal (>10kb) Multiome HiCAR | 774 | |
| chr6:2,913,547–2,914,632 | 74.8 kb | Distal (>10kb) Multiome HiCAR | 67 | |
| chr6:2,925,788–2,926,597 | 62.4 kb | Distal (>10kb) Multiome HiCAR | 244 | |
| chr6:2,927,704–2,929,196 | 60.4 kb | Distal (>10kb) Multiome HiCAR | 154 | |
| chr6:2,931,916–2,932,749 | 56.2 kb | Distal (>10kb) Multiome HiCAR | 652 | |
| chr6:2,942,573–2,943,965 | 45.6 kb | Distal (>10kb) Multiome | 222 | |
| chr6:2,952,443–2,953,210 | 35.8 kb | Distal (>10kb) Multiome HiCAR | 649 | |
| chr6:2,970,836–2,972,016 | 17.3 kb | Distal (>10kb) Multiome HiCAR | 817 | |
| chr6:2,980,019–2,980,493 | 8.2 kb | Proximal (<10kb) | 252 | |
| chr6:2,984,790–2,985,243 | 3.4 kb | Proximal (<10kb) | 130 | |
| chr6:2,985,539–2,987,671 | 2.6 kb | Proximal (<10kb) Multiome | 402 | |
| chr6:2,987,802–2,990,098 | 1.2 kb | Proximal (<10kb) Multiome | 1173 | |
| chr6:2,990,284–2,991,348 | 2.3 kb | Proximal (<10kb) Multiome | 509 | |
| chr6:2,998,292–2,998,512 | 9.6 kb | Proximal (<10kb) | 80 | |
| chr6:2,999,131–3,000,475 | 11.1 kb | Distal (>10kb) Multiome | 930 | |
| chr6:3,041,670–3,042,232 | 53.3 kb | Distal (>10kb) Multiome | 84 | |
| chr6:3,052,936–3,054,463 | 65.1 kb | Distal (>10kb) Multiome | 864 | |
| chr6:3,063,662–3,064,609 | 75.3 kb | Distal (>10kb) Multiome | 752 | |
| chr6:3,068,179–3,069,296 | 80.1 kb | Distal (>10kb) Multiome | 1032 | |
| chr6:3,118,061–3,119,380 | 130.0 kb | Distal (>10kb) Multiome | 966 | |
| chr6:3,156,701–3,158,249 | 169.0 kb | Distal (>10kb) Multiome | 859 | |
| chr6:3,162,506–3,163,526 | 174.3 kb | Distal (>10kb) Multiome | 926 | |
| chr6:3,165,678–3,166,637 | 177.7 kb | Distal (>10kb) Multiome | 343 | |
| chr6:3,226,566–3,229,919 | 239.1 kb | Distal (>10kb) Multiome | 770 | |
| chr6:3,231,202–3,232,265 | 243.1 kb | Distal (>10kb) Multiome | 593 | |
| chr6:3,251,328–3,252,273 | 263.1 kb | Distal (>10kb) Multiome | 561 | |
| chr6:3,258,552–3,259,886 | 270.3 kb | Distal (>10kb) Multiome | 946 |
Genomic view of the NQO2 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.