Microtubules, key participants in processes such as mitosis and intracellular transport, are composed of heterodimers of alpha- and beta-tubulins. The protein encoded by this gene is a beta-tubulin. Defects in this gene are associated with complex cortical dysplasia with other brain malformations-5. Two transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jul 2015]
Transcription factors with Perturb-seq knockdown data for TUBB2A. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = TUBB2A upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of TUBB2A, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr6:2,875,264–2,877,978 | 282.0 kb | Distal (>10kb) Multiome | 812 | |
| chr6:2,902,554–2,903,750 | 254.2 kb | Distal (>10kb) Multiome | 774 | |
| chr6:2,913,547–2,914,632 | 243.7 kb | Distal (>10kb) Multiome | 67 | |
| chr6:2,925,788–2,926,597 | 231.3 kb | Distal (>10kb) Multiome | 244 | |
| chr6:2,927,704–2,929,196 | 229.3 kb | Distal (>10kb) Multiome | 154 | |
| chr6:2,931,916–2,932,749 | 225.1 kb | Distal (>10kb) Multiome | 652 | |
| chr6:2,942,573–2,943,965 | 214.5 kb | Distal (>10kb) Multiome | 222 | |
| chr6:2,952,443–2,953,210 | 204.7 kb | Distal (>10kb) Multiome | 649 | |
| chr6:2,970,836–2,972,016 | 186.2 kb | Distal (>10kb) Multiome | 817 | |
| chr6:2,985,539–2,987,671 | 171.5 kb | Distal (>10kb) Multiome | 402 | |
| chr6:2,987,802–2,990,098 | 167.7 kb | Distal (>10kb) Multiome | 1173 | |
| chr6:2,990,284–2,991,348 | 166.6 kb | Distal (>10kb) Multiome | 509 | |
| chr6:2,999,131–3,000,475 | 157.8 kb | Distal (>10kb) Multiome | 930 | |
| chr6:3,041,670–3,042,232 | 115.6 kb | Distal (>10kb) Multiome | 84 | |
| chr6:3,052,936–3,054,463 | 103.8 kb | Distal (>10kb) Multiome | 864 | |
| chr6:3,063,662–3,064,609 | 93.6 kb | Distal (>10kb) Multiome | 752 | |
| chr6:3,068,179–3,069,296 | 88.8 kb | Distal (>10kb) Multiome | 1032 | |
| chr6:3,118,061–3,119,380 | 38.9 kb | Distal (>10kb) Multiome | 966 | |
| chr6:3,156,701–3,158,249 | 77 bp | At TSS Multiome | 859 | |
| chr6:3,158,350–3,158,536 | 806 bp | At TSS | 224 | |
| chr6:3,160,270–3,160,496 | 2.7 kb | Proximal (<10kb) | 299 | |
| chr6:3,162,506–3,163,526 | 5.4 kb | Proximal (<10kb) Multiome | 926 | |
| chr6:3,165,678–3,166,637 | 8.8 kb | Proximal (<10kb) Multiome | 343 | |
| chr6:3,166,807–3,167,675 | 9.3 kb | Proximal (<10kb) | 120 | |
| chr6:3,226,566–3,229,919 | 70.2 kb | Distal (>10kb) Multiome HiCAR | 770 | |
| chr6:3,231,202–3,232,265 | 74.2 kb | Distal (>10kb) Multiome HiCAR | 593 | |
| chr6:3,251,328–3,252,273 | 94.2 kb | Distal (>10kb) Multiome HiCAR | 561 | |
| chr6:3,258,552–3,259,886 | 101.4 kb | Distal (>10kb) Multiome HiCAR | 946 | |
| chr6:3,356,075–3,356,744 | 198.8 kb | Distal (>10kb) Multiome | 475 | |
| chr6:3,414,872–3,415,397 | 257.6 kb | Distal (>10kb) Multiome | 265 | |
| chr6:3,423,549–3,424,168 | 266.3 kb | Distal (>10kb) Multiome | 107 | |
| chr6:3,455,491–3,458,021 | 299.5 kb | Distal (>10kb) Multiome | 809 |
Genomic view of the TUBB2A locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.