This gene encodes a member of the serine protease inhibitor family which are also known as serpins. The encoded protein belongs to a subfamily of intracellular serpins. This protein inhibits the activity of the effector molecule granzyme B. Overexpression of this protein may prevent cytotoxic T-lymphocytes from eliminating certain tumor cells. A pseudogene of this gene is found on chromosome 6. [provided by RefSeq, Mar 2012]
Transcription factors with Perturb-seq knockdown data for SERPINB9. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = SERPINB9 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of SERPINB9, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr6:1,523,949–1,524,556 | 1379.1 kb | Distal (>10kb) Multiome HiCAR | 361 | |
| chr6:2,634,053–2,634,953 | 268.8 kb | Distal (>10kb) Multiome | 729 | |
| chr6:2,764,624–2,766,543 | 138.0 kb | Distal (>10kb) Multiome | 1055 | |
| chr6:2,841,174–2,842,113 | 61.6 kb | Distal (>10kb) Multiome HiCAR | 959 | |
| chr6:2,875,264–2,877,978 | 27.7 kb | Distal (>10kb) Multiome | 812 | |
| chr6:2,901,434–2,902,139 | 1.2 kb | Proximal (<10kb) | 60 | |
| chr6:2,902,554–2,903,750 | 24 bp | At TSS Multiome | 774 | |
| chr6:2,913,145–2,913,320 | 9.8 kb | Proximal (<10kb) | 6 | |
| chr6:2,913,547–2,914,632 | 10.5 kb | Distal (>10kb) Multiome | 67 | |
| chr6:2,925,788–2,926,597 | 22.9 kb | Distal (>10kb) Multiome | 244 | |
| chr6:2,927,704–2,929,196 | 24.9 kb | Distal (>10kb) Multiome | 154 | |
| chr6:2,931,916–2,932,749 | 29.1 kb | Distal (>10kb) Multiome | 652 | |
| chr6:2,942,573–2,943,965 | 39.7 kb | Distal (>10kb) Multiome | 222 | |
| chr6:2,952,443–2,953,210 | 49.5 kb | Distal (>10kb) Multiome | 649 | |
| chr6:2,970,836–2,972,016 | 68.0 kb | Distal (>10kb) Multiome | 817 | |
| chr6:2,985,539–2,987,671 | 82.7 kb | Distal (>10kb) Multiome HiCAR | 402 | |
| chr6:2,987,802–2,990,098 | 86.5 kb | Distal (>10kb) Multiome HiCAR | 1173 | |
| chr6:2,990,284–2,991,348 | 87.6 kb | Distal (>10kb) Multiome | 509 | |
| chr6:2,999,131–3,000,475 | 96.5 kb | Distal (>10kb) Multiome | 930 | |
| chr6:3,041,670–3,042,232 | 138.7 kb | Distal (>10kb) Multiome | 84 | |
| chr6:3,052,936–3,054,463 | 150.5 kb | Distal (>10kb) Multiome | 864 | |
| chr6:3,063,662–3,064,609 | 160.6 kb | Distal (>10kb) Multiome HiCAR | 752 | |
| chr6:3,068,179–3,069,296 | 165.4 kb | Distal (>10kb) Multiome HiCAR | 1032 | |
| chr6:3,118,061–3,119,380 | 215.3 kb | Distal (>10kb) Multiome | 966 | |
| chr6:3,156,701–3,158,249 | 254.3 kb | Distal (>10kb) Multiome | 859 | |
| chr6:3,162,506–3,163,526 | 259.7 kb | Distal (>10kb) Multiome | 926 | |
| chr6:3,165,678–3,166,637 | 263.1 kb | Distal (>10kb) Multiome | 343 |
Genomic view of the SERPINB9 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.