The protein encoded by this gene is a member of the serpin family of proteinase inhibitors. Members of this family maintain homeostasis by neutralizing overexpressed proteinase activity through their function as suicide substrates. This protein inhibits the neutrophil-derived proteinases neutrophil elastase, cathepsin G, and proteinase-3 and thus protects tissues from damage at inflammatory sites. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2012]
Transcription factors with Perturb-seq knockdown data for SERPINB1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = SERPINB1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of SERPINB1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr6:2,588,949–2,589,819 | 252.5 kb | Distal (>10kb) Multiome | 132 | |
| chr6:2,634,053–2,634,953 | 207.3 kb | Distal (>10kb) Multiome | 729 | |
| chr6:2,764,624–2,766,543 | 76.6 kb | Distal (>10kb) Multiome | 1055 | |
| chr6:2,841,174–2,842,113 | 170 bp | At TSS Multiome | 959 | |
| chr6:2,846,357–2,846,595 | 4.5 kb | Proximal (<10kb) | 408 | |
| chr6:2,848,892–2,849,129 | 7.0 kb | Proximal (<10kb) | 149 | |
| chr6:2,875,264–2,877,978 | 33.7 kb | Distal (>10kb) Multiome | 812 | |
| chr6:2,902,554–2,903,750 | 61.5 kb | Distal (>10kb) Multiome HiCAR | 774 | |
| chr6:2,913,547–2,914,632 | 72.0 kb | Distal (>10kb) Multiome | 67 | |
| chr6:2,925,788–2,926,597 | 84.3 kb | Distal (>10kb) Multiome | 244 | |
| chr6:2,927,704–2,929,196 | 86.3 kb | Distal (>10kb) Multiome | 154 | |
| chr6:2,931,916–2,932,749 | 90.5 kb | Distal (>10kb) Multiome | 652 | |
| chr6:2,942,573–2,943,965 | 101.2 kb | Distal (>10kb) Multiome | 222 | |
| chr6:2,952,443–2,953,210 | 111.0 kb | Distal (>10kb) Multiome HiCAR | 649 | |
| chr6:2,970,836–2,972,016 | 129.5 kb | Distal (>10kb) Multiome HiCAR | 817 | |
| chr6:2,985,539–2,987,671 | 144.2 kb | Distal (>10kb) Multiome HiCAR | 402 | |
| chr6:2,987,802–2,990,098 | 148.0 kb | Distal (>10kb) Multiome HiCAR | 1173 | |
| chr6:2,990,284–2,991,348 | 149.1 kb | Distal (>10kb) Multiome | 509 | |
| chr6:2,999,131–3,000,475 | 157.9 kb | Distal (>10kb) Multiome | 930 | |
| chr6:3,041,670–3,042,232 | 200.1 kb | Distal (>10kb) Multiome | 84 | |
| chr6:3,052,936–3,054,463 | 211.9 kb | Distal (>10kb) Multiome | 864 | |
| chr6:3,063,662–3,064,609 | 222.1 kb | Distal (>10kb) Multiome HiCAR | 752 | |
| chr6:3,068,179–3,069,296 | 226.9 kb | Distal (>10kb) Multiome HiCAR | 1032 | |
| chr6:3,118,061–3,119,380 | 276.8 kb | Distal (>10kb) Multiome | 966 |
Genomic view of the SERPINB1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.