RIPK1
receptor interacting serine/threonine kinase 1 | RIP, RIP-1, RIP1

This gene encodes a member of the receptor-interacting protein (RIP) family of serine/threonine protein kinases. The encoded protein plays a role in inflammation and cell death in response to tissue damage, pathogen recognition, and as part of developmental regulation. RIPK1/RIPK3 kinase-mediated necrosis is referred to as necroptosis. Genetic disruption of this gene in mice results in death shortly after birth. [provided by RefSeq, Aug 2017]

Member of: DE-12
Biological processes 120 terms
ATP binding (GO:0005524)JUN kinase kinase kinase activity (GO:0004706)MAPK cascade (GO:0000165)T cell apoptotic process (GO:0070231)T cell apoptotic process (GO:0070231)activation of protein kinase activity (GO:0032147)amyloid fibril formation (GO:1990000)amyloid fibril formation (GO:1990000)amyloid fibril formation (GO:1990000)apoptotic process (GO:0006915)apoptotic process (GO:0006915)canonical NF-kappaB signal transduction (GO:0007249)cellular response to growth factor stimulus (GO:0071363)cellular response to hydrogen peroxide (GO:0070301)cellular response to hydrogen peroxide (GO:0070301)cellular response to tumor necrosis factor (GO:0071356)cytoplasm (GO:0005737)cytoplasm (GO:0005737)cytosol (GO:0005829)death domain binding (GO:0070513)death receptor binding (GO:0005123)death receptor binding (GO:0005123)death-inducing signaling complex (GO:0031264)endosome membrane (GO:0010008)extrinsic apoptotic signaling pathway (GO:0097191)extrinsic apoptotic signaling pathway (GO:0097191)extrinsic apoptotic signaling pathway (GO:0097191)extrinsic apoptotic signaling pathway via death domain receptors (GO:0008625)identical protein binding (GO:0042802)identical protein binding (GO:0042802)inflammatory response (GO:0006954)intracellular signal transduction (GO:0035556)intracellular signal transduction (GO:0035556)intrinsic apoptotic signaling pathway in response to DNA damage (GO:0008630)mitochondrion (GO:0005739)necroptotic process (GO:0070266)necroptotic process (GO:0070266)necroptotic process (GO:0070266)necroptotic process (GO:0070266)necroptotic signaling pathway (GO:0097527)necroptotic signaling pathway (GO:0097527)necroptotic signaling pathway (GO:0097527)necroptotic signaling pathway (GO:0097527)negative regulation of apoptotic process (GO:0043066)negative regulation of apoptotic process (GO:0043066)negative regulation of canonical NF-kappaB signal transduction (GO:0043124)negative regulation of extrinsic apoptotic signaling pathway (GO:2001237)negative regulation of extrinsic apoptotic signaling pathway (GO:2001237)negative regulation of extrinsic apoptotic signaling pathway in absence of ligand (GO:2001240)negative regulation of necroptotic process (GO:0060546)negative regulation of necroptotic process (GO:0060546)plasma membrane (GO:0005886)plasma membrane (GO:0005886)plasma membrane (GO:0005886)positive regulation of JNK cascade (GO:0046330)positive regulation of JNK cascade (GO:0046330)positive regulation of apoptotic process (GO:0043065)positive regulation of apoptotic process (GO:0043065)positive regulation of canonical NF-kappaB signal transduction (GO:0043123)positive regulation of canonical NF-kappaB signal transduction (GO:0043123)positive regulation of canonical NF-kappaB signal transduction (GO:0043123)positive regulation of canonical NF-kappaB signal transduction (GO:0043123)positive regulation of execution phase of apoptosis (GO:1900119)positive regulation of extrinsic apoptotic signaling pathway (GO:2001238)positive regulation of extrinsic apoptotic signaling pathway (GO:2001238)positive regulation of gene expression (GO:0010628)positive regulation of inflammatory response (GO:0050729)positive regulation of inflammatory response (GO:0050729)positive regulation of interleukin-6-mediated signaling pathway (GO:0070105)positive regulation of interleukin-6-mediated signaling pathway (GO:0070105)positive regulation of interleukin-8 production (GO:0032757)positive regulation of macrophage differentiation (GO:0045651)positive regulation of miRNA processing (GO:1903800)positive regulation of necroptotic process (GO:0060545)positive regulation of necroptotic process (GO:0060545)positive regulation of neuron apoptotic process (GO:0043525)positive regulation of non-canonical NF-kappaB signal transduction (GO:1901224)positive regulation of phosphorylation (GO:0042327)positive regulation of programmed cell death (GO:0043068)positive regulation of programmed necrotic cell death (GO:0062100)positive regulation of reactive oxygen species metabolic process (GO:2000379)positive regulation of transcription by RNA polymerase II (GO:0045944)positive regulation of tumor necrosis factor production (GO:0032760)positive regulation of tumor necrosis factor-mediated signaling pathway (GO:1903265)programmed necrotic cell death (GO:0097300)programmed necrotic cell death (GO:0097300)protein binding (GO:0005515)protein homodimerization activity (GO:0042803)protein homodimerization activity (GO:0042803)protein kinase activity (GO:0004672)protein kinase activity (GO:0004672)protein kinase activity (GO:0004672)protein serine kinase activity (GO:0106310)protein serine/threonine kinase activity (GO:0004674)protein serine/threonine kinase activity (GO:0004674)protein serine/threonine kinase activity (GO:0004674)protein serine/threonine kinase activity (GO:0004674)protein serine/threonine kinase binding (GO:0120283)protein serine/threonine kinase binding (GO:0120283)protein serine/threonine phosphatase activity (GO:0004722)protein-containing complex (GO:0032991)protein-containing complex (GO:0032991)protein-containing complex binding (GO:0044877)protein-containing complex binding (GO:0044877)regulation of necroptotic process (GO:0060544)regulation of reactive oxygen species metabolic process (GO:2000377)response to oxidative stress (GO:0006979)response to oxidative stress (GO:0006979)response to tumor necrosis factor (GO:0034612)ripoptosome (GO:0097342)ripoptosome assembly (GO:0097343)ripoptosome assembly involved in necroptotic process (GO:1901026)ripoptosome assembly involved in necroptotic process (GO:1901026)signal transduction (GO:0007165)signaling adaptor activity (GO:0035591)signaling receptor complex (GO:0043235)tumor necrosis factor-mediated signaling pathway (GO:0033209)tumor necrosis factor-mediated signaling pathway (GO:0033209)tumor necrosis factor-mediated signaling pathway (GO:0033209)ubiquitin protein ligase binding (GO:0031625)
Expression (TPM)
RIPK1 — as a Regulated Gene

TFs regulating RIPK1 0 TFs

Transcription factors with Perturb-seq knockdown data for RIPK1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = RIPK1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.

Data: Effect:
TF Mean coef Binding Outlier TF→Gene link

Elements linked to RIPK1

Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of RIPK1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.

Accessibility Element Dist. to TSS Link type TFs
chr6:2,764,624–2,766,543 298.6 kb Distal (>10kb) Multiome 1055
chr6:2,841,174–2,842,113 222.2 kb Distal (>10kb) Multiome HiCAR 959
chr6:2,875,264–2,877,978 188.3 kb Distal (>10kb) Multiome 812
chr6:2,902,554–2,903,750 160.5 kb Distal (>10kb) Multiome HiCAR 774
chr6:2,913,547–2,914,632 150.0 kb Distal (>10kb) Multiome 67
chr6:2,925,788–2,926,597 137.7 kb Distal (>10kb) Multiome 244
chr6:2,927,704–2,929,196 135.6 kb Distal (>10kb) Multiome 154
chr6:2,931,916–2,932,749 131.5 kb Distal (>10kb) Multiome 652
chr6:2,942,573–2,943,965 120.8 kb Distal (>10kb) Multiome 222
chr6:2,952,443–2,953,210 111.0 kb Distal (>10kb) Multiome 649
chr6:2,970,836–2,972,016 92.5 kb Distal (>10kb) Multiome 817
chr6:2,985,539–2,987,671 77.8 kb Distal (>10kb) Multiome 402
chr6:2,987,802–2,990,098 74.0 kb Distal (>10kb) Multiome HiCAR 1173
chr6:2,990,284–2,991,348 72.9 kb Distal (>10kb) Multiome HiCAR 509
chr6:2,999,131–3,000,475 64.1 kb Distal (>10kb) Multiome HiCAR 930
chr6:3,041,670–3,042,232 21.9 kb Distal (>10kb) Multiome 84
chr6:3,052,936–3,054,463 10.1 kb Distal (>10kb) Multiome 864
chr6:3,063,662–3,064,609 72 bp At TSS Multiome 752
chr6:3,068,179–3,069,296 4.9 kb Proximal (<10kb) Multiome 1032
chr6:3,118,061–3,119,380 54.8 kb Distal (>10kb) Multiome 966
chr6:3,156,701–3,158,249 93.8 kb Distal (>10kb) Multiome 859
chr6:3,162,506–3,163,526 99.1 kb Distal (>10kb) Multiome 926
chr6:3,165,678–3,166,637 102.5 kb Distal (>10kb) Multiome 343
chr6:3,226,566–3,229,919 163.9 kb Distal (>10kb) Multiome 770
chr6:3,231,202–3,232,265 167.9 kb Distal (>10kb) Multiome 593
chr6:3,251,328–3,252,273 187.9 kb Distal (>10kb) Multiome 561
chr6:3,258,552–3,259,886 195.1 kb Distal (>10kb) Multiome 946
chr6:3,356,075–3,356,744 292.5 kb Distal (>10kb) Multiome 475

Genome Browser

Genomic view of the RIPK1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.

chr6:2,754,624 – 3,366,744
Proximal 1 kb Distal 10 kb Multiome HiCAR ATAC-seq RNA-seq
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