chr5 : 122,067,355 – 122,067,881

526 bp 79 TFs 1 linked gene

This 526 bp open chromatin element is linked to LOX and is bound by 79 transcription factors.

Linked Genes

1 gene

Gene	Expression	Dist. to TSS	Distance	Link type
LOX		9.3 kb	Proximal	Proximity

Chromatin Accessibility

Genome Browser

Genomic view centred on this element. Tracks include ATAC-seq accessibility, RNA-seq expression, TF binding peaks, and element-to-gene loop arcs across the ESC → DE time course.

Transcription factors with ChIP-seq peak overlap or TOBIAS motif footprint evidence at this element.

TF Binding

79 transcription factors

AR 5 datasets

ChIP MDA-MB-453 ERP001226.AR.MDA-MB-453 149 bp overlap

ChIP MDA-MB-453 ERP003503.AR.MDA-MB-453 215 bp overlap

ChIP PC-3_R1881 GSE54110.AR.PC-3_R1881 193 bp overlap

ChIP VCaP_R1881_4H GSE84432.AR.VCaP_R1881_4H 178 bp overlap

ChIP prostate-cancer_PDX_35 GSE130408.AR.prostate-cancer_PDX_35 159 bp overlap

BRD4 2 datasets

ChIP CD4_JG1 GSE33281.BRD4.CD4_JG1 188 bp overlap

ChIP Kelly_resistant GSE103030.BRD4.Kelly_resistant 167 bp overlap

CASZ1 1 dataset

ChIP rhabdomyosarcoma_DOX GSE126142.CASZ1.rhabdomyosarcoma_DOX 300 bp overlap

CHD7 1 dataset

ChIP hiPSC_derived_neural-crest-cell GSE108506.CHD7.hiPSC_derived_neural-crest-cell 181 bp overlap

DMRT3 1 dataset

Motif DE_12h DE_12h-DMRT3_MA0610.2 7 bp overlap

DMRTA1 1 dataset

Motif DE_12h DE_12h-DMRTA1_MA1707.2 10 bp overlap

DMRTA2 1 dataset

Motif DE_12h DE_12h-DMRTA2_MA1478.2 6 bp overlap

DMRTC2 1 dataset

Motif DE_12h DE_12h-DMRTC2_MA1479.2 11 bp overlap

DUX4 1 dataset

Motif DE_12h DE_12h-DUX4_MA0468.1 11 bp overlap

EHF 1 dataset

Motif DE_12h DE_12h-EHF_MA0598.4 9 bp overlap

ELF1 1 dataset

Motif DE_12h DE_12h-ELF1_MA0473.4 9 bp overlap

ELF2 1 dataset

Motif DE_12h DE_12h-ELF2_MA1483.3 10 bp overlap

ELF3 3 datasets

Motif DE_12h DE_12h-ELF3_MA0640.3 9 bp overlap

ChIP PDAC GSE64557.ELF3.PDAC 494 bp overlap

ChIP PDAC_KOKLF5 GSE64557.ELF3.PDAC_KOKLF5 464 bp overlap

ELF4 1 dataset

Motif DE_12h DE_12h-ELF4_MA0641.1 12 bp overlap

ELK4 1 dataset

Motif DE_12h DE_12h-ELK4_MA0076.3 9 bp overlap

ELL2 1 dataset

ChIP HeLa_DOX_EGF GSE40632.ELL2.HeLa_DOX_EGF 184 bp overlap

EP300 1 dataset

ChIP MCF-7_shCtrl GSE128445.EP300.MCF-7_shCtrl 235 bp overlap

ESR1 3 datasets

ChIP MCF-7_TamR GSE128445.ESR1.MCF-7_TamR 425 bp overlap

ChIP MDA-MB-134-VI_ESTROGEN GSE51022.ESR1.MDA-MB-134-VI_ESTROGEN 255 bp overlap

ChIP ZR751 ERP000783.ESR1.ZR751 228 bp overlap

ETV1 2 datasets

ChIP A-375 GSE80443.ETV1.A-375 211 bp overlap

Motif DE_12h DE_12h-ETV1_MA0761.3 9 bp overlap

ETV2::FOXI1 1 dataset

Motif DE_12h DE_12h-ETV2FOXI1_MA1942.2 11 bp overlap

ETV2::HOXB13 1 dataset

Motif DE_12h DE_12h-ETV2HOXB13_MA1943.2 13 bp overlap

ETV6 1 dataset

Motif DE_12h DE_12h-ETV6_MA0645.2 9 bp overlap

ETV7 1 dataset

Motif DE_12h DE_12h-ETV7_MA1708.2 9 bp overlap

Elf5 1 dataset

Motif DE_12h DE_12h-Elf5_MA0136.4 8 bp overlap

Erg 1 dataset

Motif DE_12h DE_12h-Erg_MA0474.4 10 bp overlap

FLI1::FOXI1 1 dataset

Motif DE_12h DE_12h-FLI1FOXI1_MA1950.2 11 bp overlap

FOXA1 17 datasets

ChIP LAPC-4_CST_DHT GSE123618.FOXA1.LAPC-4_CST_DHT 311 bp overlap

ChIP LNCaP-C4-2B_CST GSE123618.FOXA1.LNCaP-C4-2B_CST 168 bp overlap

ChIP LNCaP_R1881 GSE69043.FOXA1.LNCaP_R1881 184 bp overlap

ChIP MCF-7 GSE59530.FOXA1.MCF-7 142 bp overlap

ChIP MCF-7-TAMR-1_4OH-Tam GSE75201.FOXA1.MCF-7-TAMR-1_4OH-Tam 176 bp overlap

ChIP MCF-7_E2 GSE60270.FOXA1.MCF-7_E2 277 bp overlap

ChIP MCF-7_E2 GSE59530.FOXA1.MCF-7_E2 148 bp overlap

ChIP MCF-7_TAMR_E2_TAM ERP000380.FOXA1.MCF-7_TAMR_E2_TAM 186 bp overlap

ChIP MCF-7_TNF GSE59530.FOXA1.MCF-7_TNF 154 bp overlap

ChIP MCF-7_TamR GSE128445.FOXA1.MCF-7_TamR 383 bp overlap

ChIP PDAC GSE64557.FOXA1.PDAC 401 bp overlap

ChIP ZR-75-1_estrogen_ab2 GSE112969.FOXA1.ZR-75-1_estrogen_ab2 227 bp overlap

ChIP ZR-75-1_vehicle_ab2 GSE112969.FOXA1.ZR-75-1_vehicle_ab2 222 bp overlap

ChIP ZR751_DEX GSE72249.FOXA1.ZR751_DEX 292 bp overlap

ChIP ZR751_E2 GSE72249.FOXA1.ZR751_E2 381 bp overlap

ChIP ZR751_E2_TAM ERP000380.FOXA1.ZR751_E2_TAM 248 bp overlap

ChIP breast-cancer_Veh-2860 GSE128018.FOXA1.breast-cancer_Veh-2860 143 bp overlap

GABPA 1 dataset

Motif DE_12h DE_12h-GABPA_MA0062.4 10 bp overlap

GATA2 1 dataset

ChIP LNCaP_CSFCS GSE69043.GATA2.LNCaP_CSFCS 161 bp overlap

GRHL2 1 dataset

ChIP HBE GSE46194.GRHL2.HBE 168 bp overlap

HAND2 1 dataset

ChIP SK-N-BE2-C GSE94822.HAND2.SK-N-BE2-C 203 bp overlap

HOXB13 1 dataset

ChIP prostate-cancer_PDX_70 GSE130408.HOXB13.prostate-cancer_PDX_70 59 bp overlap

IKZF1 1 dataset

Motif DE_12h DE_12h-IKZF1_MA1508.2 8 bp overlap

IKZF2 1 dataset

Motif DE_12h DE_12h-IKZF2_MA2326.1 6 bp overlap

Ikzf3 1 dataset

Motif DE_12h DE_12h-Ikzf3_MA1992.2 9 bp overlap

KDM5B 1 dataset

ChIP HCC2157 GSE46055.KDM5B.HCC2157 155 bp overlap

LIN54 1 dataset

Motif DE_12h DE_12h-LIN54_MA0619.2 7 bp overlap

MAF 1 dataset

Motif DE_12h DE_12h-MAF_MA1520.2 13 bp overlap

MAFA 1 dataset

Motif DE_12h DE_12h-MAFA_MA1521.2 13 bp overlap

MSANTD3 1 dataset

Motif DE_12h DE_12h-MSANTD3_MA1523.2 7 bp overlap

MYOD1 1 dataset

ChIP RD_shSNAI2 GSE137168.MYOD1.RD_shSNAI2 293 bp overlap

NR1D1 1 dataset

Motif DE_12h DE_12h-NR1D1_MA1531.2 14 bp overlap

NR1H2::RXRA 1 dataset

Motif DE_12h DE_12h-NR1H2RXRA_MA0115.1 17 bp overlap

NR2C1 1 dataset

Motif DE_12h DE_12h-NR2C1_MA1535.2 6 bp overlap

NR2C2 1 dataset

Motif DE_12h DE_12h-NR2C2_MA1536.2 6 bp overlap

NR3C1 1 dataset

ChIP BEAS-2B_DEX GSE125623.NR3C1.BEAS-2B_DEX 168 bp overlap

Nr1H2 1 dataset

Motif DE_12h DE_12h-Nr1H2_MA1996.2 6 bp overlap

Nr1H4 1 dataset

Motif DE_12h DE_12h-Nr1H4_MA1110.3 6 bp overlap

Nr1h3 1 dataset

Motif DE_12h DE_12h-Nr1h3_MA2337.1 6 bp overlap

Nr2F6 1 dataset

Motif DE_12h DE_12h-Nr2F6_MA0728.1 15 bp overlap

Nr2e3 1 dataset

Motif DE_12h DE_12h-Nr2e3_MA0164.2 6 bp overlap

PAX6 1 dataset

Motif DE_12h DE_12h-PAX6_MA0069.1 14 bp overlap

POU2F3 1 dataset

Motif DE_12h DE_12h-POU2F3_MA0627.3 9 bp overlap

PRDM6 1 dataset

ChIP HEK293 GSE76494.PRDM6.HEK293 160 bp overlap

RARA 1 dataset

Motif DE_12h DE_12h-RARA_MA0729.1 18 bp overlap

RELB 1 dataset

Motif DE_12h DE_12h-RELB_MA1117.2 7 bp overlap

Rarb 1 dataset

Motif DE_12h DE_12h-Rarb_MA0857.1 16 bp overlap

Rarg 1 dataset

Motif DE_12h DE_12h-Rarg_MA0859.2 15 bp overlap

SIX2 4 datasets

Motif DE_12h DE_12h-SIX2_MA1119.2 11 bp overlap

ChIP HEK GSE73865.SIX2.HEK 526 bp overlap

ChIP kidney_fetal_16w GSE75948.SIX2.kidney_fetal_16w 438 bp overlap

ChIP kidney_fetal_17w GSE75948.SIX2.kidney_fetal_17w 456 bp overlap

SMAD2 2 datasets

Motif DE_12h DE_12h-SMAD2_MA1964.2 6 bp overlap

SMARCA4 1 dataset

ChIP 501-mel_SHSOX10 GSE61965.SMARCA4.501-mel_SHSOX10 262 bp overlap

SPIB 1 dataset

Motif DE_12h DE_12h-SPIB_MA0081.3 13 bp overlap

STAT1::STAT2 1 dataset

Motif DE_12h DE_12h-STAT1STAT2_MA0517.2 13 bp overlap

STAT3 1 dataset

ChIP MDA-MB-468_EtOH GSE85579.STAT3.MDA-MB-468_EtOH 168 bp overlap

Spi1 1 dataset

Motif DE_12h DE_12h-Spi1_MA0080.7 13 bp overlap

TBX2 1 dataset

ChIP Kelly GSE94822.TBX2.Kelly 151 bp overlap

TCF7L2 1 dataset

ChIP MDA-MB-453 GSE45201.TCF7L2.MDA-MB-453 372 bp overlap

TFAP2A 2 datasets

Motif DE_12h DE_12h-TFAP2A_MA0003.5 9 bp overlap

ChIP MCF-7_E2 GSE60270.TFAP2A.MCF-7_E2 196 bp overlap

TFAP2B 1 dataset

Motif DE_12h DE_12h-TFAP2B_MA0812.2 9 bp overlap

TFAP2C 5 datasets

ChIP HCC1954 GSE126897.TFAP2C.HCC1954 266 bp overlap

ChIP MCF-7_E2 GSE23852.TFAP2C.MCF-7_E2 201 bp overlap

ChIP MCF-7_ETOH GSE23852.TFAP2C.MCF-7_ETOH 237 bp overlap

ChIP UCLA1-hESCs_TFAP2C--_1d_TFAP2C_Induc GSE101074.TFAP2C.UCLA1-hESCs_TFAP2C--_1d_TFAP2C_Induc 395 bp overlap

ChIP UCLA1-hESCs_TFAP2C--_2d_TFAP2C_Induc GSE101074.TFAP2C.UCLA1-hESCs_TFAP2C--_2d_TFAP2C_Induc 387 bp overlap

TFAP2E 1 dataset

Motif DE_12h DE_12h-TFAP2E_MA1569.2 9 bp overlap

TFAP4 1 dataset

ChIP DLD-1 GSE46935.TFAP4.DLD-1 251 bp overlap

USP7 1 dataset

ChIP HEK293T GSE61048.USP7.HEK293T 166 bp overlap

ZBTB11 1 dataset

Motif DE_12h DE_12h-ZBTB11_MA2329.1 9 bp overlap

ZBTB7A 1 dataset

Motif DE_12h DE_12h-ZBTB7A_MA0750.3 9 bp overlap

ZNF175 1 dataset

Motif DE_12h DE_12h-ZNF175_MA2332.1 9 bp overlap

ZNF460 1 dataset

Motif DE_12h DE_12h-ZNF460_MA1596.1 16 bp overlap

ZNF660 2 datasets

ChIP HEK293 ENCFF282RUS 289 bp overlap

ChIP HEK293 ENCSR283DOU.ZNF660.HEK293 320 bp overlap

ZNF770 2 datasets

Motif DE_12h DE_12h-ZNF770_MA2099.1 8 bp overlap

ChIP HEK293 GSE76494.ZNF770.HEK293 148 bp overlap