This gene encodes a member of the lysyl oxidase family of proteins. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed to generate a regulatory propeptide and the mature enzyme. The copper-dependent amine oxidase activity of this enzyme functions in the crosslinking of collagens and elastin, while the propeptide may play a role in tumor suppression. In addition, defects in this gene have been linked with predisposition to thoracic aortic aneurysms and dissections. [provided by RefSeq, Jul 2016]
Transcription factors with Perturb-seq knockdown data for LOX. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = LOX upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of LOX, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr5:121,961,557–121,962,409 | 115.3 kb | Distal (>10kb) Multiome | 978 | |
| chr5:122,067,355–122,067,881 | 9.3 kb | Proximal (<10kb) | 79 | |
| chr5:122,076,611–122,078,738 | 1.1 kb | Proximal (<10kb) Multiome | 761 | |
| chr5:122,081,390–122,082,068 | 4.2 kb | Proximal (<10kb) | 67 | |
| chr5:122,310,677–122,313,387 | 235.0 kb | Distal (>10kb) Multiome | 423 |
Genomic view of the LOX locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.