chr4 : 183,345,366 – 183,346,138

772 bp 78 TFs 4 linked genes

This 772 bp open chromatin element is linked to 4 target genes and is bound by 78 transcription factors.

Linked Genes

4 genes

Gene	Dist. to TSS	Distance	Link type
CDKN2AIP	98.9 kb	Distal	Multiome
ING2-DT	158.7 kb	Distal	Multiome
ING2	159.3 kb	Distal	Multiome
WWC2	246.5 kb	Distal	Multiome

Chromatin Accessibility

Genome Browser

Genomic view centred on this element. Tracks include ATAC-seq accessibility, RNA-seq expression, TF binding peaks, and element-to-gene loop arcs across the ESC → DE time course.

Transcription factors with ChIP-seq peak overlap or TOBIAS motif footprint evidence at this element.

TF Binding

78 transcription factors

ATF4 1 dataset

Motif DE_36h DE_36h-ATF4_MA0833.3 10 bp overlap

Arid3a 1 dataset

Motif DE_36h DE_36h-Arid3a_MA0151.1 6 bp overlap

BARX1 1 dataset

Motif DE_36h DE_36h-BARX1_MA0875.2 6 bp overlap

BRD4 1 dataset

ChIP NCI-H1963_shNONT GSE145028.BRD4.NCI-H1963_shNONT 296 bp overlap

BSX 1 dataset

Motif DE_36h DE_36h-BSX_MA0876.2 6 bp overlap

CBFA2T2 1 dataset

ChIP K562 ENCFF963TXY 363 bp overlap

DLX1 1 dataset

Motif DE_36h DE_36h-DLX1_MA0879.3 6 bp overlap

DLX6 1 dataset

Motif DE_36h DE_36h-DLX6_MA0882.2 6 bp overlap

Dlx3 1 dataset

Motif DE_36h DE_36h-Dlx3_MA0880.2 6 bp overlap

Dlx4 1 dataset

Motif DE_36h DE_36h-Dlx4_MA0881.2 6 bp overlap

EOMES 3 datasets

Motif DE_36h DE_36h-EOMES_MA0800.2 9 bp overlap

ChIP hESC GSE26097.EOMES.hESC 739 bp overlap

EWSR1-FLI1 1 dataset

Motif DE_36h DE_36h-EWSR1-FLI1_MA0149.1 18 bp overlap

FLI1 1 dataset

ChIP A-673_1_KRAB_GFP GSE106914.FLI1.A-673_1_KRAB_GFP 223 bp overlap

FOXA2 2 datasets

ChIP DE DE-FOXA2-1 731 bp overlap

ChIP DE DE-FOXA2-2 772 bp overlap

GATA4 2 datasets

ChIP DE DE-GATA4-1 772 bp overlap

ChIP DE DE-GATA4-2 772 bp overlap

GATA6 9 datasets

ChIP DE DE-GATA6-1 761 bp overlap

ChIP DE DE-GATA6-2 772 bp overlap

ChIP DE_D1 S09-DE-d1-GATA6-exp1 687 bp overlap

ChIP DE_D1 S14-DE-d1-GATA6-exp1 772 bp overlap

ChIP DE_D1 S41-DE-d1-GATA6-exp2 772 bp overlap

ChIP DE_D2 S55-DE-d2-GATA6-exp2 763 bp overlap

ChIP HUES-8_DE_JNKi GSE109524.GATA6.HUES-8_DE_JNKi 772 bp overlap

ChIP HUES-8_DE_ctrl GSE109524.GATA6.HUES-8_DE_ctrl 767 bp overlap

ChIP endoderm_KO GSE117136.GATA6.endoderm_KO 772 bp overlap

GBX2 1 dataset

Motif DE_36h DE_36h-GBX2_MA0890.2 6 bp overlap

HESX1 1 dataset

Motif DE_36h DE_36h-HESX1_MA0894.2 6 bp overlap

HOXA7 1 dataset

Motif DE_36h DE_36h-HOXA7_MA1498.3 6 bp overlap

Hmx2 1 dataset

Motif DE_36h DE_36h-Hmx2_MA0897.2 15 bp overlap

Hnf1A 1 dataset

Motif DE_36h DE_36h-Hnf1A_MA1991.2 10 bp overlap

JUN 4 datasets

ChIP DE_D1 S40-DE-d1-JUN-exp2 285 bp overlap

ChIP DE_D1 S40-DE-d1-JUN-exp2 364 bp overlap

ChIP DE_D2 S02-DE-d2-JUN-exp1 248 bp overlap

ChIP HUES-8_DE_ctrl GSE109524.JUN.HUES-8_DE_ctrl 639 bp overlap

LBX2 1 dataset

Motif DE_36h DE_36h-LBX2_MA0699.2 6 bp overlap

LHX2 1 dataset

Motif DE_36h DE_36h-LHX2_MA0700.3 6 bp overlap

MAX 2 datasets

ChIP NCI-H2171 GSE41105.MAX.NCI-H2171 283 bp overlap

ChIP NCI-H2171 GSE36354.MAX.NCI-H2171 220 bp overlap

MED1 1 dataset

ChIP HUVEC-C_siCTL GSE124892.MED1.HUVEC-C_siCTL 185 bp overlap

MEIS1 1 dataset

Motif DE_36h DE_36h-MEIS1_MA0498.3 5 bp overlap

MGA 4 datasets

Motif DE_36h DE_36h-MGA_MA0801.1 8 bp overlap

ChIP K-562 ENCSR710WLO.MGA.K-562 240 bp overlap

ChIP K562 ENCFF140CEX 330 bp overlap

ChIP K562 ENCFF140CEX 531 bp overlap

MGA::EVX1 1 dataset

Motif DE_36h DE_36h-MGAEVX1_MA1960.2 11 bp overlap

MSX1 1 dataset

Motif DE_36h DE_36h-MSX1_MA0666.3 6 bp overlap

MSX2 1 dataset

Motif DE_36h DE_36h-MSX2_MA0708.3 6 bp overlap

MYOD1 1 dataset

ChIP rhabdomyosarcoma GSE50413.MYOD1.rhabdomyosarcoma 156 bp overlap

Msx3 1 dataset

Motif DE_36h DE_36h-Msx3_MA0709.2 6 bp overlap

NCOR1 1 dataset

ChIP K562 ENCFF788MPU 324 bp overlap

NFRKB 1 dataset

ChIP K-562 ENCSR657EOF.NFRKB.K-562 200 bp overlap

Nobox 1 dataset

Motif DE_36h DE_36h-Nobox_MA0125.2 6 bp overlap

PAX6 1 dataset

Motif DE_36h DE_36h-PAX6_MA0069.1 14 bp overlap

PAX7 1 dataset

ChIP H9_DOX GSE98976.PAX7.H9_DOX 221 bp overlap

PBX3 1 dataset

Motif DE_36h DE_36h-PBX3_MA1114.2 11 bp overlap

PKNOX1 1 dataset

Motif DE_36h DE_36h-PKNOX1_MA0782.3 10 bp overlap

POU4F2 1 dataset

ChIP HNPC_DIF GSE74814.POU4F2.HNPC_DIF 132 bp overlap

RARA 1 dataset

ChIP hiPSC_D4 GSE109172.RARA.hiPSC_D4 212 bp overlap

RAX 1 dataset

Motif DE_36h DE_36h-RAX_MA0718.2 6 bp overlap

Rhox11 1 dataset

Motif DE_36h DE_36h-Rhox11_MA0629.2 9 bp overlap

SIX2 1 dataset

ChIP HEK GSE73865.SIX2.HEK 300 bp overlap

SMAD2 1 dataset

ChIP endoderm GSE29422.SMAD2.endoderm 250 bp overlap

SMAD2-3 3 datasets

ChIP HUES-8_DE GSE109524.SMAD2-3.HUES-8_DE 772 bp overlap

ChIP HUES-8_DE_JNKi GSE109524.SMAD2-3.HUES-8_DE_JNKi 772 bp overlap

ChIP HUES-8_DE_ctrl GSE109524.SMAD2-3.HUES-8_DE_ctrl 772 bp overlap

SMAD2_3 5 datasets

ChIP DE_D1 S07-DE-d1-SMAD2_3-exp1 772 bp overlap

ChIP DE_D1 S12-DE-d1-SMAD2_3-exp1 772 bp overlap

ChIP DE_D1 S39-DE-d1-SMAD2_3-exp2 745 bp overlap

ChIP DE_D2 S01-DE-d2-SMAD2_3-exp1 772 bp overlap

ChIP DE_D2 S53-DE-d2-SMAD2_3-exp2 772 bp overlap

SMAD3 1 dataset

ChIP endoderm GSE29422.SMAD3.endoderm 207 bp overlap

SMAD4 2 datasets

ChIP endoderm GSE29422.SMAD4.endoderm 421 bp overlap

ChIP endoderm GSE29422.SMAD4.endoderm 177 bp overlap

SMARCA4 1 dataset

ChIP NSC GSE125033.SMARCA4.NSC 335 bp overlap

SMARCC1 1 dataset

ChIP DE_D1 S15-DE-d1-BAF155-exp1 649 bp overlap

SOX15 1 dataset

Motif DE_36h DE_36h-SOX15_MA1152.2 7 bp overlap

SOX17 1 dataset

ChIP DE_D2 DED2-SOX17_Batch_II 428 bp overlap

SOX17_M 1 dataset

ChIP DE_D2 DED2-SOX17-M_Batch_II 772 bp overlap

SOX2 1 dataset

ChIP HNSC GSE69479.SOX2.HNSC 389 bp overlap

SOX21 1 dataset

Motif DE_36h DE_36h-SOX21_MA0866.1 15 bp overlap

T 2 datasets

ChIP H9_ENDODERM GSE60606.T.H9_ENDODERM 707 bp overlap

ChIP H9_MESODERM GSE60606.T.H9_MESODERM 635 bp overlap

TBR1 1 dataset

Motif DE_36h DE_36h-TBR1_MA0802.2 9 bp overlap

TBX1 2 datasets

Motif DE_36h DE_36h-TBX1_MA0805.1 8 bp overlap

TBX15 1 dataset

Motif DE_36h DE_36h-TBX15_MA0803.1 8 bp overlap

TBX18 1 dataset

Motif DE_36h DE_36h-TBX18_MA1565.2 9 bp overlap

TBX2 1 dataset

Motif DE_36h DE_36h-TBX2_MA0688.2 9 bp overlap

TBX20 1 dataset

Motif DE_36h DE_36h-TBX20_MA0689.1 11 bp overlap

TBX21 1 dataset

Motif DE_36h DE_36h-TBX21_MA0690.3 10 bp overlap

TBX3 1 dataset

Motif DE_36h DE_36h-TBX3_MA1566.3 9 bp overlap

TBX4 1 dataset

Motif DE_36h DE_36h-TBX4_MA0806.1 8 bp overlap

TBX5 1 dataset

Motif DE_36h DE_36h-TBX5_MA0807.1 8 bp overlap

TCF7L2 1 dataset

Motif DE_36h DE_36h-TCF7L2_MA0523.2 9 bp overlap

Tbx6 1 dataset

Motif DE_36h DE_36h-Tbx6_MA1567.3 9 bp overlap

ZBTB33 1 dataset

ChIP K-562 ENCSR876GXA.ZBTB33.K-562 190 bp overlap

ZEB1 1 dataset

ChIP neuron_bipolar_doxy_4d ENCSR418KUS.ZEB1.neuron_bipolar_doxy_4d 122 bp overlap

ZIC2 1 dataset

ChIP HEK293 ENCFF033NQQ 469 bp overlap

ZNF24 2 datasets

ChIP K-562 ENCSR695EQB.ZNF24.K-562 169 bp overlap

ChIP K562 ENCFF877JCX 214 bp overlap

ZNF324 1 dataset

Motif DE_36h DE_36h-ZNF324_MA1977.2 14 bp overlap

ZNF547 1 dataset

Motif DE_36h DE_36h-ZNF547_MA2334.1 13 bp overlap

ZNF592 1 dataset

ChIP K-562 ENCSR249BHQ.ZNF592.K-562 249 bp overlap

ZNF675 1 dataset

Motif DE_36h DE_36h-ZNF675_MA1714.2 19 bp overlap