This gene encodes a member of the WW-and-C2-domain-containing family of proteins. Members of this family have two N-terminal WW domains that mediate binding to target proteins harboring L/PPxY motifs, an internal C2 domain for membrane association, and C-terminal alpha protein kinase C binding sites and class III PDZ domain-interaction motifs. Proteins of this family are able to form homo- and heterodimers and to modulate hippo pathway signaling. [provided by RefSeq, Sep 2016]
Transcription factors with Perturb-seq knockdown data for WWC2. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = WWC2 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of WWC2, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr4:182,806,223–182,807,324 | 292.7 kb | Distal (>10kb) Multiome | 477 | |
| chr4:182,916,637–182,918,352 | 181.9 kb | Distal (>10kb) Multiome | 800 | |
| chr4:182,925,182–182,925,655 | 173.8 kb | Distal (>10kb) Multiome | 389 | |
| chr4:183,008,425–183,009,297 | 90.5 kb | Distal (>10kb) Multiome | 112 | |
| chr4:183,075,620–183,076,390 | 23.4 kb | Distal (>10kb) Multiome HiCAR | 86 | |
| chr4:183,097,228–183,100,333 | 144 bp | At TSS Multiome | 964 | |
| chr4:183,104,959–183,105,877 | 5.7 kb | Proximal (<10kb) | 66 | |
| chr4:183,182,941–183,183,813 | 84.2 kb | Distal (>10kb) Multiome | 555 | |
| chr4:183,329,433–183,330,280 | 230.7 kb | Distal (>10kb) Multiome HiCAR | 124 | |
| chr4:183,345,366–183,346,138 | 246.5 kb | Distal (>10kb) Multiome | 78 | |
| chr4:183,390,334–183,391,979 | 292.1 kb | Distal (>10kb) Multiome HiCAR | 190 | |
| chr4:183,398,351–183,399,038 | 299.6 kb | Distal (>10kb) Multiome HiCAR | 567 | |
| chr4:183,407,083–183,407,593 | 308.0 kb | Distal (>10kb) Multiome HiCAR | 550 | |
| chr4:183,443,703–183,445,380 | 345.2 kb | Distal (>10kb) Multiome HiCAR | 1063 | |
| chr4:183,503,782–183,506,533 | 406.9 kb | Distal (>10kb) Multiome | 969 |
Genomic view of the WWC2 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.