The protein encoded by this gene regulates the DNA damage response through several different signaling pathways. One such pathway is the p53-HDM2-p21(WAF1) pathway, which is critical to the DNA damage response. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2015]
Transcription factors with Perturb-seq knockdown data for CDKN2AIP. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = CDKN2AIP upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of CDKN2AIP, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr4:183,182,941–183,183,813 | 261.3 kb | Distal (>10kb) Multiome | 555 | |
| chr4:183,329,433–183,330,280 | 114.7 kb | Distal (>10kb) Multiome | 124 | |
| chr4:183,345,366–183,346,138 | 98.9 kb | Distal (>10kb) Multiome | 78 | |
| chr4:183,390,334–183,391,979 | 53.3 kb | Distal (>10kb) Multiome | 190 | |
| chr4:183,398,351–183,399,038 | 45.9 kb | Distal (>10kb) Multiome | 567 | |
| chr4:183,407,083–183,407,593 | 37.4 kb | Distal (>10kb) Multiome | 550 | |
| chr4:183,436,565–183,436,762 | 7.9 kb | Proximal (<10kb) | 42 | |
| chr4:183,443,703–183,445,380 | 191 bp | At TSS Multiome | 1063 | |
| chr4:183,503,782–183,506,533 | 61.5 kb | Distal (>10kb) Multiome | 969 | |
| chr4:183,658,630–183,659,843 | 214.5 kb | Distal (>10kb) Multiome HiCAR | 779 | |
| chr4:183,722,750–183,723,572 | 278.4 kb | Distal (>10kb) Multiome | 395 |
Genomic view of the CDKN2AIP locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.