This gene is a member of the inhibitor of growth (ING) family. Members of the ING family associate with and modulate the activity of histone acetyltransferase (HAT) and histone deacetylase (HDAC) complexes and function in DNA repair and apoptosis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2014]
Transcription factors with Perturb-seq knockdown data for ING2. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ING2 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ING2, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr4:183,329,433–183,330,280 | 175.1 kb | Distal (>10kb) Multiome | 124 | |
| chr4:183,345,366–183,346,138 | 159.3 kb | Distal (>10kb) Multiome | 78 | |
| chr4:183,390,334–183,391,979 | 113.7 kb | Distal (>10kb) Multiome | 190 | |
| chr4:183,398,351–183,399,038 | 106.2 kb | Distal (>10kb) Multiome | 567 | |
| chr4:183,407,083–183,407,593 | 97.8 kb | Distal (>10kb) Multiome | 550 | |
| chr4:183,443,703–183,445,380 | 60.6 kb | Distal (>10kb) Multiome | 1063 | |
| chr4:183,503,782–183,506,533 | 1.1 kb | Proximal (<10kb) Multiome | 969 | |
| chr4:183,509,443–183,509,619 | 4.4 kb | Proximal (<10kb) | 1 | |
| chr4:183,658,630–183,659,843 | 154.2 kb | Distal (>10kb) Multiome HiCAR | 779 | |
| chr4:183,722,750–183,723,572 | 218.0 kb | Distal (>10kb) Multiome | 395 | |
| chr4:183,797,040–183,798,833 | 292.6 kb | Distal (>10kb) Multiome | 400 |
Genomic view of the ING2 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.